How Can Network-Pharmacology Contribute to Antiepileptic Drug Development?
Network-pharmacology is a field of pharmacology emerging from the observation that most clinical drugs have multiple targets, contrasting with the previously dominant <i>magic bullet</i> paradigm which proposed the search of exquisitely selective drugs. What is more, drug targets are oft...
| Autores: | , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2014 |
| País: | Argentina |
| Institución: | Universidad Nacional de La Plata |
| Repositorio: | SEDICI (UNLP) |
| Idioma: | español |
| OAI Identifier: | oai:sedici.unlp.edu.ar:10915/102558 |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/102558 |
| Access Level: | acceso abierto |
| Palabra clave: | Ciencias Exactas Química Biología Drug-protein networks Network analysis Epilepsy Drug repositioning Drug repurposing |
| Sumario: | Network-pharmacology is a field of pharmacology emerging from the observation that most clinical drugs have multiple targets, contrasting with the previously dominant <i>magic bullet</i> paradigm which proposed the search of exquisitely selective drugs. What is more, drug targets are often involved in multiple diseases and frequently present co-expression patterns. Therefore, useful therapeutic information can be drawn from network representations of drug targets. Here, we discuss potential applications of drug-target networks in the field of antiepileptic drug development. |
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