Age-related changes in the response of intestinal cells to parathyroid hormone

The concept of the role(s) of parathyroid hormone (PTH), has expanded from that on acting on the classical target tissues, bone and kidney, to the intestine where its actions are of regulatory and developmental importance: regulation of intracellular calcium through modulation of second messengers a...

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Detalles Bibliográficos
Autor: Russo, Ana Josefa
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2004
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/97814
Acceso en línea:http://hdl.handle.net/11336/97814
Access Level:acceso abierto
Palabra clave:AGEING
INTESTINAL CELLS
PARATHYROID HORMONE (PTH)
PTH RECEPTOR
SIGNAL TRANSDUCTION
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
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repository_id_str
spelling Age-related changes in the response of intestinal cells to parathyroid hormoneRusso, Ana JosefaAGEINGINTESTINAL CELLSPARATHYROID HORMONE (PTH)PTH RECEPTORSIGNAL TRANSDUCTIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The concept of the role(s) of parathyroid hormone (PTH), has expanded from that on acting on the classical target tissues, bone and kidney, to the intestine where its actions are of regulatory and developmental importance: regulation of intracellular calcium through modulation of second messengers and, activation of mitogenic cascades leading to cell proliferation. Several causes have been postulated to modify the hormone response in intestinal cells with ageing, among them, alterations of PTH receptor (PTHR1) binding sites, reduced expression of G proteins and hormone signal transduction changes. The current review summarizes the actual knowledge regarding the molecular and biochemical basis of age-impaired PTH receptor-mediated signaling in intestinal cells. A fundamental understanding of why PTH functions are impaired with age will enhance our understanding of its importance in intestinal cell physiology.Fil: Russo, Ana Josefa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaElsevier Ireland2004-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/97814Russo, Ana Josefa; Age-related changes in the response of intestinal cells to parathyroid hormone; Elsevier Ireland; Mechanisms of Ageing and Development; 125; 12; 12-2004; 877-8880047-6374CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.mad.2004.05.008info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0047637404001800info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:53:41Zoai:ri.conicet.gov.ar:11336/97814instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:53:41.721CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Age-related changes in the response of intestinal cells to parathyroid hormone
title Age-related changes in the response of intestinal cells to parathyroid hormone
spellingShingle Age-related changes in the response of intestinal cells to parathyroid hormone
Russo, Ana Josefa
AGEING
INTESTINAL CELLS
PARATHYROID HORMONE (PTH)
PTH RECEPTOR
SIGNAL TRANSDUCTION
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
title_short Age-related changes in the response of intestinal cells to parathyroid hormone
title_full Age-related changes in the response of intestinal cells to parathyroid hormone
title_fullStr Age-related changes in the response of intestinal cells to parathyroid hormone
title_full_unstemmed Age-related changes in the response of intestinal cells to parathyroid hormone
title_sort Age-related changes in the response of intestinal cells to parathyroid hormone
dc.creator.none.fl_str_mv Russo, Ana Josefa
author Russo, Ana Josefa
author_facet Russo, Ana Josefa
author_role author
dc.subject.none.fl_str_mv AGEING
INTESTINAL CELLS
PARATHYROID HORMONE (PTH)
PTH RECEPTOR
SIGNAL TRANSDUCTION
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
topic AGEING
INTESTINAL CELLS
PARATHYROID HORMONE (PTH)
PTH RECEPTOR
SIGNAL TRANSDUCTION
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
description The concept of the role(s) of parathyroid hormone (PTH), has expanded from that on acting on the classical target tissues, bone and kidney, to the intestine where its actions are of regulatory and developmental importance: regulation of intracellular calcium through modulation of second messengers and, activation of mitogenic cascades leading to cell proliferation. Several causes have been postulated to modify the hormone response in intestinal cells with ageing, among them, alterations of PTH receptor (PTHR1) binding sites, reduced expression of G proteins and hormone signal transduction changes. The current review summarizes the actual knowledge regarding the molecular and biochemical basis of age-impaired PTH receptor-mediated signaling in intestinal cells. A fundamental understanding of why PTH functions are impaired with age will enhance our understanding of its importance in intestinal cell physiology.
publishDate 2004
dc.date.none.fl_str_mv 2004-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/97814
Russo, Ana Josefa; Age-related changes in the response of intestinal cells to parathyroid hormone; Elsevier Ireland; Mechanisms of Ageing and Development; 125; 12; 12-2004; 877-888
0047-6374
CONICET Digital
CONICET
url http://hdl.handle.net/11336/97814
identifier_str_mv Russo, Ana Josefa; Age-related changes in the response of intestinal cells to parathyroid hormone; Elsevier Ireland; Mechanisms of Ageing and Development; 125; 12; 12-2004; 877-888
0047-6374
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mad.2004.05.008
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0047637404001800
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799195477283962880
score 15.811543

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