The mongolian gerbil (Meriones unguiculatus) as a model for inflammation-promoted prostate carcinogenesis

One of the recognized issues in prostate cancer research is the lack of animal models allowing the research of pathological, biochemical, and genetic factors in immunocompetent animals. Our research group has successfully employed the gerbil in several studies for prostate diseases. In the present w...

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Autores: Quintar, Amado Alfredo, Gonçalves, Bianca F., Taboga, Sebastião R., Maldonado, Cristina Alicia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/63898
Acceso en línea:http://hdl.handle.net/11336/63898
Access Level:acceso abierto
Palabra clave:Androgens
Cancer
Gerbil
Inflammation
Prostate
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
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repository_id_str
spelling The mongolian gerbil (Meriones unguiculatus) as a model for inflammation-promoted prostate carcinogenesisQuintar, Amado AlfredoGonçalves, Bianca F.Taboga, Sebastião R.Maldonado, Cristina AliciaAndrogensCancerGerbilInflammationProstatehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3One of the recognized issues in prostate cancer research is the lack of animal models allowing the research of pathological, biochemical, and genetic factors in immunocompetent animals. Our research group has successfully employed the gerbil in several studies for prostate diseases. In the present work, we aimed to analyze the effect of chronic bacterial inflammation on N-methyl-N-nitrosourea (MNU)-induced prostate carcinogenesis in gerbils. Histopathological assessment of the prostatic complex revealed that treatment combinations with MNU plus testosterone or bacterial infection resulted in a promotion of prostate cancer, with bacterial inflammation being more effective in increasing premalignant and malignant tissular alterations than testosterone in the prostate. Furthermore, chronic bacterial inflammation itself induced premalignant lesions in the ventral lobe and increased their frequency in the dorsolateral lobe as well as malignant lesions in the ventral prostate. These animals showed a rich inflammatory microenvironment, characterized as intraluminal and periductal foci. These data indicate that chronic inflammation induced by Escherichia coli acts as a potent tumor promoter, in the early stages of carcinogenesis in the gerbil, in line with the hypothesis of inflammation supporting several steps of tumor development in the prostate gland.Fil: Quintar, Amado Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba;Facultad de Ciencias Médicas;Cátedra de Bioquímica Molecular; ; ArgentinaFil: Gonçalves, Bianca F.. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Taboga, Sebastião R.. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Maldonado, Cristina Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba;Facultad de Ciencias Médicas;Cátedra de Bioquímica Molecular; ; ArgentinaAcademic Press Ltd - Elsevier Science Ltd2017-11-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/63898Quintar, Amado Alfredo; Gonçalves, Bianca F.; Taboga, Sebastião R.; Maldonado, Cristina Alicia; The mongolian gerbil (Meriones unguiculatus) as a model for inflammation-promoted prostate carcinogenesis; Academic Press Ltd - Elsevier Science Ltd; Cell Biology International; 41; 11; 25-11-2017; 1234-12381065-6995CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/cbin.10789info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/cbin.10789info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:47:54Zoai:ri.conicet.gov.ar:11336/63898instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:47:55.2CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The mongolian gerbil (Meriones unguiculatus) as a model for inflammation-promoted prostate carcinogenesis
title The mongolian gerbil (Meriones unguiculatus) as a model for inflammation-promoted prostate carcinogenesis
spellingShingle The mongolian gerbil (Meriones unguiculatus) as a model for inflammation-promoted prostate carcinogenesis
Quintar, Amado Alfredo
Androgens
Cancer
Gerbil
Inflammation
Prostate
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
title_short The mongolian gerbil (Meriones unguiculatus) as a model for inflammation-promoted prostate carcinogenesis
title_full The mongolian gerbil (Meriones unguiculatus) as a model for inflammation-promoted prostate carcinogenesis
title_fullStr The mongolian gerbil (Meriones unguiculatus) as a model for inflammation-promoted prostate carcinogenesis
title_full_unstemmed The mongolian gerbil (Meriones unguiculatus) as a model for inflammation-promoted prostate carcinogenesis
title_sort The mongolian gerbil (Meriones unguiculatus) as a model for inflammation-promoted prostate carcinogenesis
dc.creator.none.fl_str_mv Quintar, Amado Alfredo
Gonçalves, Bianca F.
Taboga, Sebastião R.
Maldonado, Cristina Alicia
author Quintar, Amado Alfredo
author_facet Quintar, Amado Alfredo
Gonçalves, Bianca F.
Taboga, Sebastião R.
Maldonado, Cristina Alicia
author_role author
author2 Gonçalves, Bianca F.
Taboga, Sebastião R.
Maldonado, Cristina Alicia
author2_role author
author
author
dc.subject.none.fl_str_mv Androgens
Cancer
Gerbil
Inflammation
Prostate
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
topic Androgens
Cancer
Gerbil
Inflammation
Prostate
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
description One of the recognized issues in prostate cancer research is the lack of animal models allowing the research of pathological, biochemical, and genetic factors in immunocompetent animals. Our research group has successfully employed the gerbil in several studies for prostate diseases. In the present work, we aimed to analyze the effect of chronic bacterial inflammation on N-methyl-N-nitrosourea (MNU)-induced prostate carcinogenesis in gerbils. Histopathological assessment of the prostatic complex revealed that treatment combinations with MNU plus testosterone or bacterial infection resulted in a promotion of prostate cancer, with bacterial inflammation being more effective in increasing premalignant and malignant tissular alterations than testosterone in the prostate. Furthermore, chronic bacterial inflammation itself induced premalignant lesions in the ventral lobe and increased their frequency in the dorsolateral lobe as well as malignant lesions in the ventral prostate. These animals showed a rich inflammatory microenvironment, characterized as intraluminal and periductal foci. These data indicate that chronic inflammation induced by Escherichia coli acts as a potent tumor promoter, in the early stages of carcinogenesis in the gerbil, in line with the hypothesis of inflammation supporting several steps of tumor development in the prostate gland.
publishDate 2017
dc.date.none.fl_str_mv 2017-11-25
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/63898
Quintar, Amado Alfredo; Gonçalves, Bianca F.; Taboga, Sebastião R.; Maldonado, Cristina Alicia; The mongolian gerbil (Meriones unguiculatus) as a model for inflammation-promoted prostate carcinogenesis; Academic Press Ltd - Elsevier Science Ltd; Cell Biology International; 41; 11; 25-11-2017; 1234-1238
1065-6995
CONICET Digital
CONICET
url http://hdl.handle.net/11336/63898
identifier_str_mv Quintar, Amado Alfredo; Gonçalves, Bianca F.; Taboga, Sebastião R.; Maldonado, Cristina Alicia; The mongolian gerbil (Meriones unguiculatus) as a model for inflammation-promoted prostate carcinogenesis; Academic Press Ltd - Elsevier Science Ltd; Cell Biology International; 41; 11; 25-11-2017; 1234-1238
1065-6995
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/cbin.10789
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/cbin.10789
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Ltd - Elsevier Science Ltd
publisher.none.fl_str_mv Academic Press Ltd - Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 15.811543

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