Low-dose calcium supplementation for preventing pre-eclampsia: a systematic review and commentary

BACKGROUND: Epidemiological data link low dietary calcium with pre-eclampsia. Current recommendations are for 1.5-2 g/day calcium supplementation for low-intake pregnant women, based on randomised controlled trials of ≥1 g/day calcium supplementation from 20 weeks of gestation. This is problematic l...

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Detalles Bibliográficos
Autores: Hofmeyr, G. J., Belizan, Jose, Von Dadelszen, P.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/33064
Acceso en línea:http://hdl.handle.net/11336/33064
Access Level:acceso abierto
Palabra clave:Calcium Replacement
Calcium Supplement
Eclampsia
Low-Dose Calcium
Pre-Eclampsia
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
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spelling Low-dose calcium supplementation for preventing pre-eclampsia: a systematic review and commentaryHofmeyr, G. J.Belizan, JoseVon Dadelszen, P.Calcium ReplacementCalcium SupplementEclampsiaLow-Dose CalciumPre-Eclampsiahttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3BACKGROUND: Epidemiological data link low dietary calcium with pre-eclampsia. Current recommendations are for 1.5-2 g/day calcium supplementation for low-intake pregnant women, based on randomised controlled trials of ≥1 g/day calcium supplementation from 20 weeks of gestation. This is problematic logistically in low-resource settings; excessive calcium may be harmful; and 20 weeks may be too late to alter outcomes. OBJECTIVES: To review the impact of lower dose calcium supplementation on pre-eclampsia risk. SEARCH STRATEGY AND SELECTION CRITERIA: We searched PubMed and the Cochrane Pregnancy and Childbirth Group trials register. DATA COLLECTION AND ANALYSIS: Two authors extracted data from eligible randomised and quasi-randomised trials of low-dose calcium (LDC, <1 g/day), with or without other supplements. MAIN RESULTS: Pre-eclampsia was reduced consistently with LDC with or without co-supplements (nine trials, 2234 women, relative risk [RR] 0.38; 95% confidence interval [95% CI] 0.28-0.52), as well as for subgroups: LDC alone (four trials, 980 women, RR 0.36; 95% CI 0.23-0.57]); LDC plus linoleic acid (two trials, 134 women, RR 0.23; 95% CI 0.09-0.60); LDC plus vitamin D (two trials, 1060 women, RR 0.49; 0.31-0.78) and a trend for LDC plus antioxidants (one trial, 60 women, RR 0.24; 95% CI 0.06-1.01). Overall results were consistent with the single quality trial of LDC alone (171 women, RR 0.30; 95% CI 0.06-1.38). LDC plus antioxidants commencing at 8-12 weeks tended to reduce miscarriage (one trial, 60 women, RR 0.06; 95% CI 0.00-1.04). CONCLUSIONS: These limited data are consistent with LDC reducing the risk of pre-eclampsia; confirming this in sufficiently powered randomised controlled trials would have implications for current guidelines and their global implementation.Fil: Hofmeyr, G. J.. University of the Witwatersrand/; Sudáfrica. University of Fort Hare; Sudáfrica. Calcium and Pre-eclampsia Study Group; CanadáFil: Belizan, Jose. Calcium and Pre-eclampsia Study Group; Canadá. Instituto de Efectividad Clínica y Sanitaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Von Dadelszen, P.. Calcium and Pre-eclampsia Study Group; Canadá. University of British Columbia; CanadáWiley2014-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/33064Von Dadelszen, P.; Hofmeyr, G. J.; Belizan, Jose; Low-dose calcium supplementation for preventing pre-eclampsia: a systematic review and commentary; Wiley; BJOG - An International Journal of Obstetrics and Gynaecology; 121; 8; 3-2014; 951-9571470-03281471-0528CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/1471-0528.12613/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1111/1471-0528.12613info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282055/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:22:19Zoai:ri.conicet.gov.ar:11336/33064instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:22:19.411CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Low-dose calcium supplementation for preventing pre-eclampsia: a systematic review and commentary
title Low-dose calcium supplementation for preventing pre-eclampsia: a systematic review and commentary
spellingShingle Low-dose calcium supplementation for preventing pre-eclampsia: a systematic review and commentary
Hofmeyr, G. J.
Calcium Replacement
Calcium Supplement
Eclampsia
Low-Dose Calcium
Pre-Eclampsia
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
title_short Low-dose calcium supplementation for preventing pre-eclampsia: a systematic review and commentary
title_full Low-dose calcium supplementation for preventing pre-eclampsia: a systematic review and commentary
title_fullStr Low-dose calcium supplementation for preventing pre-eclampsia: a systematic review and commentary
title_full_unstemmed Low-dose calcium supplementation for preventing pre-eclampsia: a systematic review and commentary
title_sort Low-dose calcium supplementation for preventing pre-eclampsia: a systematic review and commentary
dc.creator.none.fl_str_mv Hofmeyr, G. J.
Belizan, Jose
Von Dadelszen, P.
author Hofmeyr, G. J.
author_facet Hofmeyr, G. J.
Belizan, Jose
Von Dadelszen, P.
author_role author
author2 Belizan, Jose
Von Dadelszen, P.
author2_role author
author
dc.subject.none.fl_str_mv Calcium Replacement
Calcium Supplement
Eclampsia
Low-Dose Calcium
Pre-Eclampsia
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
topic Calcium Replacement
Calcium Supplement
Eclampsia
Low-Dose Calcium
Pre-Eclampsia
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
description BACKGROUND: Epidemiological data link low dietary calcium with pre-eclampsia. Current recommendations are for 1.5-2 g/day calcium supplementation for low-intake pregnant women, based on randomised controlled trials of ≥1 g/day calcium supplementation from 20 weeks of gestation. This is problematic logistically in low-resource settings; excessive calcium may be harmful; and 20 weeks may be too late to alter outcomes. OBJECTIVES: To review the impact of lower dose calcium supplementation on pre-eclampsia risk. SEARCH STRATEGY AND SELECTION CRITERIA: We searched PubMed and the Cochrane Pregnancy and Childbirth Group trials register. DATA COLLECTION AND ANALYSIS: Two authors extracted data from eligible randomised and quasi-randomised trials of low-dose calcium (LDC, <1 g/day), with or without other supplements. MAIN RESULTS: Pre-eclampsia was reduced consistently with LDC with or without co-supplements (nine trials, 2234 women, relative risk [RR] 0.38; 95% confidence interval [95% CI] 0.28-0.52), as well as for subgroups: LDC alone (four trials, 980 women, RR 0.36; 95% CI 0.23-0.57]); LDC plus linoleic acid (two trials, 134 women, RR 0.23; 95% CI 0.09-0.60); LDC plus vitamin D (two trials, 1060 women, RR 0.49; 0.31-0.78) and a trend for LDC plus antioxidants (one trial, 60 women, RR 0.24; 95% CI 0.06-1.01). Overall results were consistent with the single quality trial of LDC alone (171 women, RR 0.30; 95% CI 0.06-1.38). LDC plus antioxidants commencing at 8-12 weeks tended to reduce miscarriage (one trial, 60 women, RR 0.06; 95% CI 0.00-1.04). CONCLUSIONS: These limited data are consistent with LDC reducing the risk of pre-eclampsia; confirming this in sufficiently powered randomised controlled trials would have implications for current guidelines and their global implementation.
publishDate 2014
dc.date.none.fl_str_mv 2014-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/33064
Von Dadelszen, P.; Hofmeyr, G. J.; Belizan, Jose; Low-dose calcium supplementation for preventing pre-eclampsia: a systematic review and commentary; Wiley; BJOG - An International Journal of Obstetrics and Gynaecology; 121; 8; 3-2014; 951-957
1470-0328
1471-0528
CONICET Digital
CONICET
url http://hdl.handle.net/11336/33064
identifier_str_mv Von Dadelszen, P.; Hofmeyr, G. J.; Belizan, Jose; Low-dose calcium supplementation for preventing pre-eclampsia: a systematic review and commentary; Wiley; BJOG - An International Journal of Obstetrics and Gynaecology; 121; 8; 3-2014; 951-957
1470-0328
1471-0528
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/1471-0528.12613/abstract
info:eu-repo/semantics/altIdentifier/doi/10.1111/1471-0528.12613
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282055/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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