The effect of substituted sydnonimines on coronary smooth muscle relaxation and cyclic guanosine monophosphate levels

In vitro experiments on precontracted canine coronary arteries were performed to study the direct relaxant effects of molsidomine (MOLS) and its active metabolite, SIN-1, and to determine if there is a relationship between effect and cGMP level elevations. The effects of MOLS and SIN-1 were compared...

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Detalles Bibliográficos
Autores: Rinaldi, Gustavo, Cingolani, Horacio Eugenio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:1983
País:Argentina
Institución:Universidad Nacional de La Plata
Repositorio:SEDICI (UNLP)
Idioma:inglés
OAI Identifier:oai:sedici.unlp.edu.ar:10915/138345
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/138345
Access Level:acceso abierto
Palabra clave:Ciencias Médicas
Coronary arteries
Molsidomine
Cyclic guanosine monophosphate
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spelling The effect of substituted sydnonimines on coronary smooth muscle relaxation and cyclic guanosine monophosphate levelsRinaldi, GustavoCingolani, Horacio EugenioCiencias MédicasCoronary arteriesMolsidomineCyclic guanosine monophosphateIn vitro experiments on precontracted canine coronary arteries were performed to study the direct relaxant effects of molsidomine (MOLS) and its active metabolite, SIN-1, and to determine if there is a relationship between effect and cGMP level elevations. The effects of MOLS and SIN-1 were compared with those of a classic vasodilator, nitroglycerin (NTG). At equimolar doses (10(-6)M) SIN-1 exerted greater relaxant effect than NTG (80 +/- 2% and 60 +/- 5%, respectively) in spite of the fact that it produced less of an increase in cyclic guanosine monophosphate (cGMP) levels. cGMP levels fell rapidly after they peaked, but relaxation was maintained. cGMP elevation preceded the induction of relaxation by NTG but not that induced by SIN-1. Relaxation occurred faster after NTG than after SIN-1. Since SIN-1 has a greater relaxant effect than NTG in spite of the fact that SIN-1 induces less of an increase in cGMP levels and the fact that the peak elevation does not precede the onset of relaxation, the causal nexus between GMP level elevation and relaxation effect after sydnonimines should be challenged.Centro de Investigaciones Cardiovasculares1983info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf1315-1320http://sedici.unlp.edu.ar/handle/10915/138345enginfo:eu-repo/semantics/altIdentifier/issn/0009-7322info:eu-repo/semantics/altIdentifier/issn/1524-4539info:eu-repo/semantics/altIdentifier/doi/10.1161/01.cir.68.6.1315info:eu-repo/semantics/altIdentifier/pmid/6315260info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2024-05-08T13:10:47Zoai:sedici.unlp.edu.ar:10915/138345Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292024-05-08 13:10:47.791SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv The effect of substituted sydnonimines on coronary smooth muscle relaxation and cyclic guanosine monophosphate levels
title The effect of substituted sydnonimines on coronary smooth muscle relaxation and cyclic guanosine monophosphate levels
spellingShingle The effect of substituted sydnonimines on coronary smooth muscle relaxation and cyclic guanosine monophosphate levels
Rinaldi, Gustavo
Ciencias Médicas
Coronary arteries
Molsidomine
Cyclic guanosine monophosphate
title_short The effect of substituted sydnonimines on coronary smooth muscle relaxation and cyclic guanosine monophosphate levels
title_full The effect of substituted sydnonimines on coronary smooth muscle relaxation and cyclic guanosine monophosphate levels
title_fullStr The effect of substituted sydnonimines on coronary smooth muscle relaxation and cyclic guanosine monophosphate levels
title_full_unstemmed The effect of substituted sydnonimines on coronary smooth muscle relaxation and cyclic guanosine monophosphate levels
title_sort The effect of substituted sydnonimines on coronary smooth muscle relaxation and cyclic guanosine monophosphate levels
dc.creator.none.fl_str_mv Rinaldi, Gustavo
Cingolani, Horacio Eugenio
author Rinaldi, Gustavo
author_facet Rinaldi, Gustavo
Cingolani, Horacio Eugenio
author_role author
author2 Cingolani, Horacio Eugenio
author2_role author
dc.subject.none.fl_str_mv Ciencias Médicas
Coronary arteries
Molsidomine
Cyclic guanosine monophosphate
topic Ciencias Médicas
Coronary arteries
Molsidomine
Cyclic guanosine monophosphate
description In vitro experiments on precontracted canine coronary arteries were performed to study the direct relaxant effects of molsidomine (MOLS) and its active metabolite, SIN-1, and to determine if there is a relationship between effect and cGMP level elevations. The effects of MOLS and SIN-1 were compared with those of a classic vasodilator, nitroglycerin (NTG). At equimolar doses (10(-6)M) SIN-1 exerted greater relaxant effect than NTG (80 +/- 2% and 60 +/- 5%, respectively) in spite of the fact that it produced less of an increase in cyclic guanosine monophosphate (cGMP) levels. cGMP levels fell rapidly after they peaked, but relaxation was maintained. cGMP elevation preceded the induction of relaxation by NTG but not that induced by SIN-1. Relaxation occurred faster after NTG than after SIN-1. Since SIN-1 has a greater relaxant effect than NTG in spite of the fact that SIN-1 induces less of an increase in cGMP levels and the fact that the peak elevation does not precede the onset of relaxation, the causal nexus between GMP level elevation and relaxation effect after sydnonimines should be challenged.
publishDate 1983
dc.date.none.fl_str_mv 1983
dc.type.none.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/138345
url http://sedici.unlp.edu.ar/handle/10915/138345
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/issn/1524-4539
info:eu-repo/semantics/altIdentifier/doi/10.1161/01.cir.68.6.1315
info:eu-repo/semantics/altIdentifier/pmid/6315260
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
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