Synthesis, characterization and slow drug delivery of hydrogels based in N-acryloyl-tris-(hydroxymethyl) aminomethane and N-isopropyl acrylamide

In this study, new hydrogels in rod shape were prepared from N-isopropyl acrylamide (NIPA), N-acryloyl-tris-(hydroxymethyl) aminomethane (NAT) and N,N´-methylenebisacrylamide (BIS). The effect of the incorporation of NAT into poly(N-isopropyl acrylamide) (PNIPA) structures for which the monomer comp...

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Detalhes bibliográficos
Autores: Cuggino, Julio César, Strumia, Miriam Cristina, Alvarez Igarzabal, Cecilia Ines
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2011
País:Argentina
Recursos:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/12934
Acesso em linha:http://hdl.handle.net/11336/12934
Access Level:acceso abierto
Palavra-chave:Hydrogel Synthesis
Thermo-Sensitive Hydrogels
Drug Controlled Release
Corsslinked Strucutres
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/2.9
https://purl.org/becyt/ford/2
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spelling Synthesis, characterization and slow drug delivery of hydrogels based in N-acryloyl-tris-(hydroxymethyl) aminomethane and N-isopropyl acrylamideCuggino, Julio CésarStrumia, Miriam CristinaAlvarez Igarzabal, Cecilia InesHydrogel SynthesisThermo-Sensitive HydrogelsDrug Controlled ReleaseCorsslinked Strucutreshttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1https://purl.org/becyt/ford/2.9https://purl.org/becyt/ford/2In this study, new hydrogels in rod shape were prepared from N-isopropyl acrylamide (NIPA), N-acryloyl-tris-(hydroxymethyl) aminomethane (NAT) and N,N´-methylenebisacrylamide (BIS). The effect of the incorporation of NAT into poly(N-isopropyl acrylamide) (PNIPA) structures for which the monomer composition was varied from NIPA 100% to NAT 100% was explored. The rheological studies were used to test their viscoelastic properties. Swelling experiments were used to test the capacity of water absorption, the modification of the network parameters, the swelling kinetics, the temperature and pH swelling response and n (number that determines the type of diffusion of water). NAT-containing hydrogels showed values of n between 0.5 and 1, therefore the diffusion of water into the hydrogels was found to have a non-Fickian character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at high temperature that maintains the drug and hinders the release was controlled by the introduction of NAT into the network, to allow a slow drug release of ibuprofen at 37 ºC and pH 7.4.Fil: Cuggino, Julio César. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); ArgentinaFil: Strumia, Miriam Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); ArgentinaFil: Alvarez Igarzabal, Cecilia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); ArgentinaElsevier Science2011-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/12934Cuggino, Julio César; Strumia, Miriam Cristina; Alvarez Igarzabal, Cecilia Ines; Synthesis, characterization and slow drug delivery of hydrogels based in N-acryloyl-tris-(hydroxymethyl) aminomethane and N-isopropyl acrylamide; Elsevier Science; Reactive & Functional Polymers; 71; 4; 4-2011; 440-4461381-5148enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.reactfunctpolym.2011.01.002info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1381514811000083info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:00:45Zoai:ri.conicet.gov.ar:11336/12934instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:00:45.35CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Synthesis, characterization and slow drug delivery of hydrogels based in N-acryloyl-tris-(hydroxymethyl) aminomethane and N-isopropyl acrylamide
title Synthesis, characterization and slow drug delivery of hydrogels based in N-acryloyl-tris-(hydroxymethyl) aminomethane and N-isopropyl acrylamide
spellingShingle Synthesis, characterization and slow drug delivery of hydrogels based in N-acryloyl-tris-(hydroxymethyl) aminomethane and N-isopropyl acrylamide
Cuggino, Julio César
Hydrogel Synthesis
Thermo-Sensitive Hydrogels
Drug Controlled Release
Corsslinked Strucutres
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/2.9
https://purl.org/becyt/ford/2
title_short Synthesis, characterization and slow drug delivery of hydrogels based in N-acryloyl-tris-(hydroxymethyl) aminomethane and N-isopropyl acrylamide
title_full Synthesis, characterization and slow drug delivery of hydrogels based in N-acryloyl-tris-(hydroxymethyl) aminomethane and N-isopropyl acrylamide
title_fullStr Synthesis, characterization and slow drug delivery of hydrogels based in N-acryloyl-tris-(hydroxymethyl) aminomethane and N-isopropyl acrylamide
title_full_unstemmed Synthesis, characterization and slow drug delivery of hydrogels based in N-acryloyl-tris-(hydroxymethyl) aminomethane and N-isopropyl acrylamide
title_sort Synthesis, characterization and slow drug delivery of hydrogels based in N-acryloyl-tris-(hydroxymethyl) aminomethane and N-isopropyl acrylamide
dc.creator.none.fl_str_mv Cuggino, Julio César
Strumia, Miriam Cristina
Alvarez Igarzabal, Cecilia Ines
author Cuggino, Julio César
author_facet Cuggino, Julio César
Strumia, Miriam Cristina
Alvarez Igarzabal, Cecilia Ines
author_role author
author2 Strumia, Miriam Cristina
Alvarez Igarzabal, Cecilia Ines
author2_role author
author
dc.subject.none.fl_str_mv Hydrogel Synthesis
Thermo-Sensitive Hydrogels
Drug Controlled Release
Corsslinked Strucutres
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/2.9
https://purl.org/becyt/ford/2
topic Hydrogel Synthesis
Thermo-Sensitive Hydrogels
Drug Controlled Release
Corsslinked Strucutres
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/2.9
https://purl.org/becyt/ford/2
description In this study, new hydrogels in rod shape were prepared from N-isopropyl acrylamide (NIPA), N-acryloyl-tris-(hydroxymethyl) aminomethane (NAT) and N,N´-methylenebisacrylamide (BIS). The effect of the incorporation of NAT into poly(N-isopropyl acrylamide) (PNIPA) structures for which the monomer composition was varied from NIPA 100% to NAT 100% was explored. The rheological studies were used to test their viscoelastic properties. Swelling experiments were used to test the capacity of water absorption, the modification of the network parameters, the swelling kinetics, the temperature and pH swelling response and n (number that determines the type of diffusion of water). NAT-containing hydrogels showed values of n between 0.5 and 1, therefore the diffusion of water into the hydrogels was found to have a non-Fickian character. The elastic moduli and the equilibrium water content (EWC) measurements suggest that these materials may have a potential application as biomaterials. The structure of shrunken NIPA 100 at high temperature that maintains the drug and hinders the release was controlled by the introduction of NAT into the network, to allow a slow drug release of ibuprofen at 37 ºC and pH 7.4.
publishDate 2011
dc.date.none.fl_str_mv 2011-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/12934
Cuggino, Julio César; Strumia, Miriam Cristina; Alvarez Igarzabal, Cecilia Ines; Synthesis, characterization and slow drug delivery of hydrogels based in N-acryloyl-tris-(hydroxymethyl) aminomethane and N-isopropyl acrylamide; Elsevier Science; Reactive & Functional Polymers; 71; 4; 4-2011; 440-446
1381-5148
url http://hdl.handle.net/11336/12934
identifier_str_mv Cuggino, Julio César; Strumia, Miriam Cristina; Alvarez Igarzabal, Cecilia Ines; Synthesis, characterization and slow drug delivery of hydrogels based in N-acryloyl-tris-(hydroxymethyl) aminomethane and N-isopropyl acrylamide; Elsevier Science; Reactive & Functional Polymers; 71; 4; 4-2011; 440-446
1381-5148
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.reactfunctpolym.2011.01.002
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1381514811000083
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 15.81155

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