Relative bioavailability of coenzyme Q10 formulation for paediatric individualized therapy

Objectives: Conduct a preliminary comparison of the bioavailability between two formulations: commercial grade coenzyme Q10 (CoQ10) powder (solid formulation) and a new oil-in-water liquid emulsion and their effect on other antioxidants. Methods: Six healthy individuals participated in a randomized,...

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Autores: Martinefski, Manuela Romina, Samassa, Paula Tatiana, Buontempo, Fabian, Höcht, Christian, Lucangioli, Silvia Edith, Tripodi, Valeria Paula
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/39360
Acceso en línea:http://hdl.handle.net/11336/39360
Access Level:acceso abierto
Palabra clave:Coenzyme Q10
Paediatric
Pharmacokinetic
Relative Bioavailability
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
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network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Relative bioavailability of coenzyme Q10 formulation for paediatric individualized therapy
title Relative bioavailability of coenzyme Q10 formulation for paediatric individualized therapy
spellingShingle Relative bioavailability of coenzyme Q10 formulation for paediatric individualized therapy
Martinefski, Manuela Romina
Coenzyme Q10
Paediatric
Pharmacokinetic
Relative Bioavailability
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
title_short Relative bioavailability of coenzyme Q10 formulation for paediatric individualized therapy
title_full Relative bioavailability of coenzyme Q10 formulation for paediatric individualized therapy
title_fullStr Relative bioavailability of coenzyme Q10 formulation for paediatric individualized therapy
title_full_unstemmed Relative bioavailability of coenzyme Q10 formulation for paediatric individualized therapy
title_sort Relative bioavailability of coenzyme Q10 formulation for paediatric individualized therapy
dc.creator.none.fl_str_mv Martinefski, Manuela Romina
Samassa, Paula Tatiana
Buontempo, Fabian
Höcht, Christian
Lucangioli, Silvia Edith
Tripodi, Valeria Paula
author Martinefski, Manuela Romina
author_facet Martinefski, Manuela Romina
Samassa, Paula Tatiana
Buontempo, Fabian
Höcht, Christian
Lucangioli, Silvia Edith
Tripodi, Valeria Paula
author_role author
author2 Samassa, Paula Tatiana
Buontempo, Fabian
Höcht, Christian
Lucangioli, Silvia Edith
Tripodi, Valeria Paula
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Coenzyme Q10
Paediatric
Pharmacokinetic
Relative Bioavailability
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
topic Coenzyme Q10
Paediatric
Pharmacokinetic
Relative Bioavailability
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
description Objectives: Conduct a preliminary comparison of the bioavailability between two formulations: commercial grade coenzyme Q10 (CoQ10) powder (solid formulation) and a new oil-in-water liquid emulsion and their effect on other antioxidants. Methods: Six healthy individuals participated in a randomized, crossover, open, consecutive design, with a 2-week washout period. Pharmacokinetic parameters were assessed after a single and multiple intakes of 250 mg CoQ10 given daily for 1 week. Key Findings: The differences in the pharmacokinetic parameters of maximum plasma concentration, area under the curve between 0–360 and 0–4 h, elimination half-life were statistically significant with a relative bioavailability of 489% increase over solid CoQ10 formulation. A multiple dose supplementation increased plasma CoQ10 levels in both formulations, liquid emulsion performing better (2.4- vs 3.9-fold for solid and liquid formulation, respectively) without modifications on other antioxidants. Furthermore, the plasma CoQ10 at 7th day was statistically different between formulations (P < 0.05). Conclusions: The results obtained showed that liquid emulsion improves the bioavailability of CoQ10 respect to solid form which not only facilitates the individualized administration for the child but in turn could increase the therapeutic efficacy, which should be confirmed by further studies.
publishDate 2017
dc.date.none.fl_str_mv 2017-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/39360
Martinefski, Manuela Romina; Samassa, Paula Tatiana; Buontempo, Fabian; Höcht, Christian; Lucangioli, Silvia Edith; et al.; Relative bioavailability of coenzyme Q10 formulation for paediatric individualized therapy; Pharmaceutical Press-Royal Pharmaceutical Society Great Britian; Journal of Pharmacy and Pharmacology; 69; 5; 5-2017; 567-573
0022-3573
2042-7158
CONICET Digital
CONICET
url http://hdl.handle.net/11336/39360
identifier_str_mv Martinefski, Manuela Romina; Samassa, Paula Tatiana; Buontempo, Fabian; Höcht, Christian; Lucangioli, Silvia Edith; et al.; Relative bioavailability of coenzyme Q10 formulation for paediatric individualized therapy; Pharmaceutical Press-Royal Pharmaceutical Society Great Britian; Journal of Pharmacy and Pharmacology; 69; 5; 5-2017; 567-573
0022-3573
2042-7158
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/jphp.12613
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/jphp.12613
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pharmaceutical Press-Royal Pharmaceutical Society Great Britian
publisher.none.fl_str_mv Pharmaceutical Press-Royal Pharmaceutical Society Great Britian
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799195327095373824
spelling Relative bioavailability of coenzyme Q10 formulation for paediatric individualized therapyMartinefski, Manuela RominaSamassa, Paula TatianaBuontempo, FabianHöcht, ChristianLucangioli, Silvia EdithTripodi, Valeria PaulaCoenzyme Q10PaediatricPharmacokineticRelative Bioavailabilityhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Objectives: Conduct a preliminary comparison of the bioavailability between two formulations: commercial grade coenzyme Q10 (CoQ10) powder (solid formulation) and a new oil-in-water liquid emulsion and their effect on other antioxidants. Methods: Six healthy individuals participated in a randomized, crossover, open, consecutive design, with a 2-week washout period. Pharmacokinetic parameters were assessed after a single and multiple intakes of 250 mg CoQ10 given daily for 1 week. Key Findings: The differences in the pharmacokinetic parameters of maximum plasma concentration, area under the curve between 0–360 and 0–4 h, elimination half-life were statistically significant with a relative bioavailability of 489% increase over solid CoQ10 formulation. A multiple dose supplementation increased plasma CoQ10 levels in both formulations, liquid emulsion performing better (2.4- vs 3.9-fold for solid and liquid formulation, respectively) without modifications on other antioxidants. Furthermore, the plasma CoQ10 at 7th day was statistically different between formulations (P < 0.05). Conclusions: The results obtained showed that liquid emulsion improves the bioavailability of CoQ10 respect to solid form which not only facilitates the individualized administration for the child but in turn could increase the therapeutic efficacy, which should be confirmed by further studies.Fil: Martinefski, Manuela Romina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Samassa, Paula Tatiana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; ArgentinaFil: Buontempo, Fabian. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; ArgentinaFil: Höcht, Christian. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; ArgentinaFil: Lucangioli, Silvia Edith. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; ArgentinaFil: Tripodi, Valeria Paula. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaPharmaceutical Press-Royal Pharmaceutical Society Great Britian2017-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/39360Martinefski, Manuela Romina; Samassa, Paula Tatiana; Buontempo, Fabian; Höcht, Christian; Lucangioli, Silvia Edith; et al.; Relative bioavailability of coenzyme Q10 formulation for paediatric individualized therapy; Pharmaceutical Press-Royal Pharmaceutical Society Great Britian; Journal of Pharmacy and Pharmacology; 69; 5; 5-2017; 567-5730022-35732042-7158CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/jphp.12613info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/jphp.12613info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:49:10Zoai:ri.conicet.gov.ar:11336/39360instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:49:11.077CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
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