c- Src and its role in cystic fibrosis

Fil: Massip Copiz, María Macarena. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Celular y Molecular; Argentina

Detalles Bibliográficos
Autores: Massip Copiz, María Macarena, Santa Coloma, Tomás Antonio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:Argentina
Institución:Pontificia Universidad Católica Argentina
Repositorio:Repositorio Institucional (UCA)
Idioma:inglés
OAI Identifier:oai:ucacris:123456789/14562
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/14562
Access Level:acceso embargado
Palabra clave:FIBROSIS QUISTICA
GENES
CLORURO INTRACELULAR
REGULADOR DE CONDUCTANCIA DE TRANSMEMBRANA DE FIBROSIS QUISTICA
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spelling c- Src and its role in cystic fibrosisMassip Copiz, María MacarenaSanta Coloma, Tomás AntonioFIBROSIS QUISTICAGENESCLORURO INTRACELULARREGULADOR DE CONDUCTANCIA DE TRANSMEMBRANA DE FIBROSIS QUISTICAFil: Massip Copiz, María Macarena. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Celular y Molecular; ArgentinaFil: Massip Copiz, María Macarena. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Santa Coloma, Tomás Antonio. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Celular y Molecular; ArgentinaFil: Santa Coloma, Tomás Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAbstract: Cystic fibrosis (CF) is a lethal inherited disease produced by mutations in the gene encoding the CFTR chloride channel. Loss of function in the CFTR gene is associated with a not much noticed increased expression and activity of the non-receptor protein-tyrosine kinase c-Src. CF is therefore the result from the loss of CFTR chloride transport function and its consequences, including a chronic and excessive c-Src signaling. On the other hand, c-Src, encoded by the SRC gene, is involved in diverse signaling mechanisms that regulate key cellular functions such as cell proliferation, apoptosis, oxidative stress, inflammation, and innate immunity. These c-Src-regulated cellular functions are also affected in CF; however, studies exploring a direct role of c-Src in the regulation of these cellular functions in CF are yet scarce and often controversial. Here we describe the c-Src regulation and functions, with emphasis in those altered in CF, and describe the role of CFTR as a “signaling molecule” that negatively modulates c-Src expression and activity. It is also discussed the emerging role of intracellular Cl− and IL-1 as intermediate signaling effectors between CFTR and c-Src.Elsevierinfo:eu-repo/date/embargoEnd/2100-01-012016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/145620070-2463 (online)0171-933510.1016/j.ejcb.2016.08.00127530912Massip Copiz, M. M., Santa Coloma, T. A. c- Src and its role in cystic fibrosis [en línea]. European Journal of Cell Biology. 2016, 95 (10). doi: https://doi.org/10.1016/j.ejcb.2016.08.001. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14562European Journal of Cell Biology Vol.95, No.10, 2016reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/embargoedAccess2024-05-15T12:25:31Zoai:ucacris:123456789/14562instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852024-05-15 12:25:31.558Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv c- Src and its role in cystic fibrosis
title c- Src and its role in cystic fibrosis
spellingShingle c- Src and its role in cystic fibrosis
Massip Copiz, María Macarena
FIBROSIS QUISTICA
GENES
CLORURO INTRACELULAR
REGULADOR DE CONDUCTANCIA DE TRANSMEMBRANA DE FIBROSIS QUISTICA
title_short c- Src and its role in cystic fibrosis
title_full c- Src and its role in cystic fibrosis
title_fullStr c- Src and its role in cystic fibrosis
title_full_unstemmed c- Src and its role in cystic fibrosis
title_sort c- Src and its role in cystic fibrosis
dc.creator.none.fl_str_mv Massip Copiz, María Macarena
Santa Coloma, Tomás Antonio
author Massip Copiz, María Macarena
author_facet Massip Copiz, María Macarena
Santa Coloma, Tomás Antonio
author_role author
author2 Santa Coloma, Tomás Antonio
author2_role author
dc.subject.none.fl_str_mv FIBROSIS QUISTICA
GENES
CLORURO INTRACELULAR
REGULADOR DE CONDUCTANCIA DE TRANSMEMBRANA DE FIBROSIS QUISTICA
topic FIBROSIS QUISTICA
GENES
CLORURO INTRACELULAR
REGULADOR DE CONDUCTANCIA DE TRANSMEMBRANA DE FIBROSIS QUISTICA
description Fil: Massip Copiz, María Macarena. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Celular y Molecular; Argentina
publishDate 2016
dc.date.none.fl_str_mv 2016
info:eu-repo/date/embargoEnd/2100-01-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/14562
0070-2463 (online)
0171-9335
10.1016/j.ejcb.2016.08.001
27530912
Massip Copiz, M. M., Santa Coloma, T. A. c- Src and its role in cystic fibrosis [en línea]. European Journal of Cell Biology. 2016, 95 (10). doi: https://doi.org/10.1016/j.ejcb.2016.08.001. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14562
url https://repositorio.uca.edu.ar/handle/123456789/14562
identifier_str_mv 0070-2463 (online)
0171-9335
10.1016/j.ejcb.2016.08.001
27530912
Massip Copiz, M. M., Santa Coloma, T. A. c- Src and its role in cystic fibrosis [en línea]. European Journal of Cell Biology. 2016, 95 (10). doi: https://doi.org/10.1016/j.ejcb.2016.08.001. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14562
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv European Journal of Cell Biology Vol.95, No.10, 2016
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
instname_str Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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score 15.812455

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