Newborn granule cells in the ageing dentate gyrus

The dentate gyrus of the hippocampus generates neurons throughout life, but adult neurogenesis exhibits a marked age-dependent decline. Although the decrease in the rate of neurogenesis has been extensively documented in the ageing hippocampus, the specific characteristics of dentate granule cells b...

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Autores: Morgenstern, Nicolás Andrés, Lombardi, María Gabriela, Schinder, Alejandro Fabián
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2008
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/29778
Acceso en línea:http://hdl.handle.net/11336/29778
Access Level:acceso abierto
Palabra clave:Granule Cells
Animals, Newborn
Cell Differentiation
Cell Proliferation
Ageing
Dentate Gyrus
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
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spelling Newborn granule cells in the ageing dentate gyrusMorgenstern, Nicolás AndrésLombardi, María GabrielaSchinder, Alejandro FabiánGranule CellsAnimals, NewbornCell DifferentiationCell ProliferationAgeingDentate Gyrushttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The dentate gyrus of the hippocampus generates neurons throughout life, but adult neurogenesis exhibits a marked age-dependent decline. Although the decrease in the rate of neurogenesis has been extensively documented in the ageing hippocampus, the specific characteristics of dentate granule cells born in such a continuously changing environment have received little attention. We have used retroviral labelling of neural progenitor cells of the adult mouse dentate gyrus to study morphological properties of neurons born at different ages. Dendritic spine density was measured to estimate glutamatergic afferent connectivity. Fully mature neurons born at the age of 2 months display approximately 2.3 spines microm(-1) and maintain their overall morphology and spine density in 1-year-old mice. Surprisingly, granule cells born in 10-month-old mice, at which time the rate of neurogenesis has decreased by approximately 40-fold, reach a density of dendritic spines similar to that of neurons born in young adulthood. Therefore, in spite of the sharp decline in cell proliferation, differentiation and overall neuronal number, the ageing hippocampus presents a suitable environment for new surviving neurons to reach a high level of complexity, comparable to that of all other dentate granule cellsFil: Morgenstern, Nicolás Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Lombardi, María Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Schinder, Alejandro Fabián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaWiley Blackwell Publishing, Inc2008-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/29778Morgenstern, Nicolás Andrés; Lombardi, María Gabriela; Schinder, Alejandro Fabián; Newborn granule cells in the ageing dentate gyrus; Wiley Blackwell Publishing, Inc; The Journal Of Physiology; 586; 16; 6-2008; 3751-37570022-37511469-7793CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1113/jphysiol.2008.154807/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1113/jphysiol.2008.154807info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:46:01Zoai:ri.conicet.gov.ar:11336/29778instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:46:01.486CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Newborn granule cells in the ageing dentate gyrus
title Newborn granule cells in the ageing dentate gyrus
spellingShingle Newborn granule cells in the ageing dentate gyrus
Morgenstern, Nicolás Andrés
Granule Cells
Animals, Newborn
Cell Differentiation
Cell Proliferation
Ageing
Dentate Gyrus
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
title_short Newborn granule cells in the ageing dentate gyrus
title_full Newborn granule cells in the ageing dentate gyrus
title_fullStr Newborn granule cells in the ageing dentate gyrus
title_full_unstemmed Newborn granule cells in the ageing dentate gyrus
title_sort Newborn granule cells in the ageing dentate gyrus
dc.creator.none.fl_str_mv Morgenstern, Nicolás Andrés
Lombardi, María Gabriela
Schinder, Alejandro Fabián
author Morgenstern, Nicolás Andrés
author_facet Morgenstern, Nicolás Andrés
Lombardi, María Gabriela
Schinder, Alejandro Fabián
author_role author
author2 Lombardi, María Gabriela
Schinder, Alejandro Fabián
author2_role author
author
dc.subject.none.fl_str_mv Granule Cells
Animals, Newborn
Cell Differentiation
Cell Proliferation
Ageing
Dentate Gyrus
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
topic Granule Cells
Animals, Newborn
Cell Differentiation
Cell Proliferation
Ageing
Dentate Gyrus
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
description The dentate gyrus of the hippocampus generates neurons throughout life, but adult neurogenesis exhibits a marked age-dependent decline. Although the decrease in the rate of neurogenesis has been extensively documented in the ageing hippocampus, the specific characteristics of dentate granule cells born in such a continuously changing environment have received little attention. We have used retroviral labelling of neural progenitor cells of the adult mouse dentate gyrus to study morphological properties of neurons born at different ages. Dendritic spine density was measured to estimate glutamatergic afferent connectivity. Fully mature neurons born at the age of 2 months display approximately 2.3 spines microm(-1) and maintain their overall morphology and spine density in 1-year-old mice. Surprisingly, granule cells born in 10-month-old mice, at which time the rate of neurogenesis has decreased by approximately 40-fold, reach a density of dendritic spines similar to that of neurons born in young adulthood. Therefore, in spite of the sharp decline in cell proliferation, differentiation and overall neuronal number, the ageing hippocampus presents a suitable environment for new surviving neurons to reach a high level of complexity, comparable to that of all other dentate granule cells
publishDate 2008
dc.date.none.fl_str_mv 2008-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/29778
Morgenstern, Nicolás Andrés; Lombardi, María Gabriela; Schinder, Alejandro Fabián; Newborn granule cells in the ageing dentate gyrus; Wiley Blackwell Publishing, Inc; The Journal Of Physiology; 586; 16; 6-2008; 3751-3757
0022-3751
1469-7793
CONICET Digital
CONICET
url http://hdl.handle.net/11336/29778
identifier_str_mv Morgenstern, Nicolás Andrés; Lombardi, María Gabriela; Schinder, Alejandro Fabián; Newborn granule cells in the ageing dentate gyrus; Wiley Blackwell Publishing, Inc; The Journal Of Physiology; 586; 16; 6-2008; 3751-3757
0022-3751
1469-7793
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1113/jphysiol.2008.154807/abstract
info:eu-repo/semantics/altIdentifier/doi/10.1113/jphysiol.2008.154807
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 15,81155

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