Synthesis of 3-amino-2-ethoxycarbonyl pyrido[1,2-a]thieno-[2,3-d]-4-pyrimidone derivatives and their antimalarial and cytotoxic activities in vitro

A series of 3-amino-2-ethoxycarbonyl pyrido[1,2-a]thieno[2,3-d]-4-pyrimidone 10-13 were prepared in order to investigate their cytotoxicity and antimalarial activities. Some of the them showed a promising activity. The detailed synthesis, spectroscopic, computational and biological data are describe...

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Bibliographic Details
Authors: Charris, Jaime, Domínguez, José, Cordero, Mary, Orfila, Luz, Riggione, Flavia, López, Simón E., Enriz, Ricardo Daniel, Suviere, Fernando
Format: article
Status:Published version
Publication Date:2000
Country:Argentina
Institution:Consejo Nacional de Investigaciones Científicas y Técnicas
Repository:CONICET Digital (CONICET)
Language:English
OAI Identifier:oai:ri.conicet.gov.ar:11336/127111
Online Access:http://hdl.handle.net/11336/127111
Access Level:Open access
Keyword:Pyrido pyrimidines
Synthesis
Cytotoxic activities
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
Description
Summary:A series of 3-amino-2-ethoxycarbonyl pyrido[1,2-a]thieno[2,3-d]-4-pyrimidone 10-13 were prepared in order to investigate their cytotoxicity and antimalarial activities. Some of the them showed a promising activity. The detailed synthesis, spectroscopic, computational and biological data are described.

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