Automatic Glucose Control during Meals and Exercise in Type 1 Diabetes: Proof-of-Concept in Silico Tests Using a Switched LPV Approach
Keeping the blood glucose levels within the safe range during meals and exercise still represents a major hurdle not only for patients with type 1 diabetes (T1D), but also for Artificial Pancreas (AP) systems. One of the reasons a fully (autonomous) closed-loop solution has not been released onto th...
| Autores: | , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | Argentina |
| Recursos: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/155074 |
| Acesso em linha: | http://hdl.handle.net/11336/155074 |
| Access Level: | acceso embargado |
| Palavra-chave: | ARTIFICIAL PANCREAS PHYSICAL ACTIVITY SWITCHED LPV CONTROL UNANNOUNCED MEALS https://purl.org/becyt/ford/2.2 https://purl.org/becyt/ford/2 |
| Resumo: | Keeping the blood glucose levels within the safe range during meals and exercise still represents a major hurdle not only for patients with type 1 diabetes (T1D), but also for Artificial Pancreas (AP) systems. One of the reasons a fully (autonomous) closed-loop solution has not been released onto the market yet is the slow action of current insulin analogs. To partially overcome this limitation, the authors have previously designed a switched control strategy equipped with an insulin-on-board (IOB) safety loop that mitigates meal-related glucose excursions without carbohydrate counting. In this letter, a similar strategy based on a Linear Parameter-Varying (LPV) control law has been adapted to safely handle also exercise challenges with minimum user intervention. In silico results using the UVA/Padova simulator evidence that the proposed closed-loop scheme is feasible under moderate-intense exercise bouts by effectively and safely reducing the risk of hypoglycemia. |
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