Can magnesium gluconate be used as an alternative therapy for preeclampsia?

Magnesium (Mg+2) in the body plays a structural and regulatory role and it is involved in fundamental cellular reactions. It is known that Mg+2 blood levels decrease during pregnancy, which has been related to preeclampsia and premature delivery, as well as other pathologies such as cardiovascular a...

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Autores: Rangel, Heicher, Abad, Cilia, Chiarello, Delia I., Rojas, Deliana, Proverbio, Fulgencio, Marín, Reinaldo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:Argentina
Institución:Universidad Nacional de La Plata
Repositorio:SEDICI (UNLP)
Idioma:inglés
OAI Identifier:oai:sedici.unlp.edu.ar:10915/140990
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/140990
Access Level:acceso abierto
Palabra clave:Ciencias Médicas
Magnesium deficiency
preeclampsia
magnesium sulfate
magnesium gluconate
oxidative stress
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spelling Can magnesium gluconate be used as an alternative therapy for preeclampsia?Rangel, HeicherAbad, CiliaChiarello, Delia I.Rojas, DelianaProverbio, FulgencioMarín, ReinaldoCiencias MédicasMagnesium deficiencypreeclampsiamagnesium sulfatemagnesium gluconateoxidative stressMagnesium (Mg+2) in the body plays a structural and regulatory role and it is involved in fundamental cellular reactions. It is known that Mg+2 blood levels decrease during pregnancy, which has been related to preeclampsia and premature delivery, as well as other pathologies such as cardiovascular alterations and renal, gastrointestinal, neurological, and muscular dysfunctions among others. Mg+2 salts are used to treat its deficiency, and parenteral magnesium sulfate (MgSO4) is relatively effective in preeclampsia and eclampsia. The use of MgSO4 has the main disadvantage that it is mainly administered intravenously which leads to significant toxicity risks. Currently, other magnesium salts are being studied as alternative treatments. Magnesium gluconate (Mg-gluconate) has been used to prevent pregnancy-induced hypertension, showing a greater antioxidant capacity than MgSO4. Mg-gluconate can scavenge hydroxyl and alkoxyl radicals and it has been shown that it can inhibit lipid peroxidation in microsomal membranes treated in vitro with the Fenton reaction. Mg-gluconate seems to be an excellent candidate to replace MgSO4 as a therapy for preeclampsia with severe features.El magnesio (Mg+2) en el organismo, juega un papel estructural y regulador, y participa en reacciones celulares fundamentales. Se sabe que los niveles séricos de Mg+2 disminuyen durante el embarazo, lo cual se ha relacionado con la preeclampsia y el parto prematuro, así como con otras patologías como alteraciones cardiovasculares y disfunciones renales, gastrointestinales, neurológicas, musculares, entre otras. Las sales de Mg+2 se utilizan para tratar su deficiencia, y el sulfato de magnesio parenteral (MgSO4) ha demostrado ser relativamente eficaz en la preeclampsia y la eclampsia. El uso de MgSO4 tiene el principal inconveniente de que se administra principalmente por vía intravenosa, lo cual conlleva a riesgos importantes de toxicidad. Actualmente, se están estudiando otras sales de magnesio como tratamientos alternativos. El gluconato de magnesio (Mg-gluconato) se ha utilizado para prevenir la hipertensión inducida por el embarazo, mostrando una mayor capacidad antioxidante que el MgSO4. El Mg-gluconato es capaz de eliminar radicales hidroxilo y alcoxilo e inhibir la peroxidación lipídica en membranas microsomales tratadas in vitro con la reacción de Fenton. El Mg-gluconato parece ser un excelente candidato para sustituir al MgSO4 como terapia para la preeclampsia con características graves.Sociedad Argentina de Fisiología2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf39-48http://sedici.unlp.edu.ar/handle/10915/140990enginfo:eu-repo/semantics/altIdentifier/url/https://pmr.safisiol.org.ar/wp-content/uploads/2022/07/Vol-15-numero-4-2022.pdfinfo:eu-repo/semantics/altIdentifier/issn/1669-5410info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2024-05-08T13:14:06Zoai:sedici.unlp.edu.ar:10915/140990Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292024-05-08 13:14:07.024SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Can magnesium gluconate be used as an alternative therapy for preeclampsia?
title Can magnesium gluconate be used as an alternative therapy for preeclampsia?
spellingShingle Can magnesium gluconate be used as an alternative therapy for preeclampsia?
Rangel, Heicher
Ciencias Médicas
Magnesium deficiency
preeclampsia
magnesium sulfate
magnesium gluconate
oxidative stress
title_short Can magnesium gluconate be used as an alternative therapy for preeclampsia?
title_full Can magnesium gluconate be used as an alternative therapy for preeclampsia?
title_fullStr Can magnesium gluconate be used as an alternative therapy for preeclampsia?
title_full_unstemmed Can magnesium gluconate be used as an alternative therapy for preeclampsia?
title_sort Can magnesium gluconate be used as an alternative therapy for preeclampsia?
dc.creator.none.fl_str_mv Rangel, Heicher
Abad, Cilia
Chiarello, Delia I.
Rojas, Deliana
Proverbio, Fulgencio
Marín, Reinaldo
author Rangel, Heicher
author_facet Rangel, Heicher
Abad, Cilia
Chiarello, Delia I.
Rojas, Deliana
Proverbio, Fulgencio
Marín, Reinaldo
author_role author
author2 Abad, Cilia
Chiarello, Delia I.
Rojas, Deliana
Proverbio, Fulgencio
Marín, Reinaldo
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Médicas
Magnesium deficiency
preeclampsia
magnesium sulfate
magnesium gluconate
oxidative stress
topic Ciencias Médicas
Magnesium deficiency
preeclampsia
magnesium sulfate
magnesium gluconate
oxidative stress
description Magnesium (Mg+2) in the body plays a structural and regulatory role and it is involved in fundamental cellular reactions. It is known that Mg+2 blood levels decrease during pregnancy, which has been related to preeclampsia and premature delivery, as well as other pathologies such as cardiovascular alterations and renal, gastrointestinal, neurological, and muscular dysfunctions among others. Mg+2 salts are used to treat its deficiency, and parenteral magnesium sulfate (MgSO4) is relatively effective in preeclampsia and eclampsia. The use of MgSO4 has the main disadvantage that it is mainly administered intravenously which leads to significant toxicity risks. Currently, other magnesium salts are being studied as alternative treatments. Magnesium gluconate (Mg-gluconate) has been used to prevent pregnancy-induced hypertension, showing a greater antioxidant capacity than MgSO4. Mg-gluconate can scavenge hydroxyl and alkoxyl radicals and it has been shown that it can inhibit lipid peroxidation in microsomal membranes treated in vitro with the Fenton reaction. Mg-gluconate seems to be an excellent candidate to replace MgSO4 as a therapy for preeclampsia with severe features.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/140990
url http://sedici.unlp.edu.ar/handle/10915/140990
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/issn/1669-5410
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
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dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
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instname_str Universidad Nacional de La Plata
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institution UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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