Retinogenesis: Stochasticity and the competency model

The vertebrate retina is made up of seven principal cell types. These seven retinal cell types arise from multipotent retinal progenitor cells (RPCs). The competency model was proposed suggesting that RPCs undergo a series of irreversible transitions between competency states, in each of which the R...

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Authors: Barton, Alejandro, Fendrik, Alejandro José
Format: article
Status:Published version
Publication Date:2015
Country:Argentina
Institution:Consejo Nacional de Investigaciones Científicas y Técnicas
Repository:CONICET Digital (CONICET)
Language:English
OAI Identifier:oai:ri.conicet.gov.ar:11336/38365
Online Access:http://hdl.handle.net/11336/38365
Access Level:Open access
Keyword:Asymmetric Divisions
Retinal Progenitor Cells
Stochastic Development
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
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network_acronym_str AR
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spelling Retinogenesis: Stochasticity and the competency modelBarton, AlejandroFendrik, Alejandro JoséAsymmetric DivisionsRetinal Progenitor CellsStochastic Developmenthttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The vertebrate retina is made up of seven principal cell types. These seven retinal cell types arise from multipotent retinal progenitor cells (RPCs). The competency model was proposed suggesting that RPCs undergo a series of irreversible transitions between competency states, in each of which the RPCs are competent to generate a different subset of cell types, but not retinal cells generated at previous moments. In this work, we generalize the stochastic model of neurogenesis of Barton et al. (2014), assuming that the same factor that regulates the differentiation, regulates the competency. The model reproduces the timing of production of different retinal cell types in rats such as it was experimentally measured. The results show that the evolution of the competency during retinogenesis could be explained by a single factor. Its evolution during the cell cycle and the stochastic inheritance in cell divisions determine the sequence and the overlap of production of different retinal cell types during development.Fil: Barton, Alejandro. Universidad Nacional de General Sarmiento. Instituto de Ciencias; ArgentinaFil: Fendrik, Alejandro José. Universidad Nacional de General Sarmiento. Instituto de Ciencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAcademic Press Ltd - Elsevier Science Ltd2015-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/38365Barton, Alejandro; Fendrik, Alejandro José; Retinogenesis: Stochasticity and the competency model; Academic Press Ltd - Elsevier Science Ltd; Journal of Theoretical Biology; 373; 5-2015; 73-810022-5193CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jtbi.2015.03.015info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0022519315001241info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:02:57Zoai:ri.conicet.gov.ar:11336/38365instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:02:57.963CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Retinogenesis: Stochasticity and the competency model
title Retinogenesis: Stochasticity and the competency model
spellingShingle Retinogenesis: Stochasticity and the competency model
Barton, Alejandro
Asymmetric Divisions
Retinal Progenitor Cells
Stochastic Development
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
title_short Retinogenesis: Stochasticity and the competency model
title_full Retinogenesis: Stochasticity and the competency model
title_fullStr Retinogenesis: Stochasticity and the competency model
title_full_unstemmed Retinogenesis: Stochasticity and the competency model
title_sort Retinogenesis: Stochasticity and the competency model
dc.creator.none.fl_str_mv Barton, Alejandro
Fendrik, Alejandro José
author Barton, Alejandro
author_facet Barton, Alejandro
Fendrik, Alejandro José
author_role author
author2 Fendrik, Alejandro José
author2_role author
dc.subject.none.fl_str_mv Asymmetric Divisions
Retinal Progenitor Cells
Stochastic Development
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
topic Asymmetric Divisions
Retinal Progenitor Cells
Stochastic Development
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
description The vertebrate retina is made up of seven principal cell types. These seven retinal cell types arise from multipotent retinal progenitor cells (RPCs). The competency model was proposed suggesting that RPCs undergo a series of irreversible transitions between competency states, in each of which the RPCs are competent to generate a different subset of cell types, but not retinal cells generated at previous moments. In this work, we generalize the stochastic model of neurogenesis of Barton et al. (2014), assuming that the same factor that regulates the differentiation, regulates the competency. The model reproduces the timing of production of different retinal cell types in rats such as it was experimentally measured. The results show that the evolution of the competency during retinogenesis could be explained by a single factor. Its evolution during the cell cycle and the stochastic inheritance in cell divisions determine the sequence and the overlap of production of different retinal cell types during development.
publishDate 2015
dc.date.none.fl_str_mv 2015-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/38365
Barton, Alejandro; Fendrik, Alejandro José; Retinogenesis: Stochasticity and the competency model; Academic Press Ltd - Elsevier Science Ltd; Journal of Theoretical Biology; 373; 5-2015; 73-81
0022-5193
CONICET Digital
CONICET
url http://hdl.handle.net/11336/38365
identifier_str_mv Barton, Alejandro; Fendrik, Alejandro José; Retinogenesis: Stochasticity and the competency model; Academic Press Ltd - Elsevier Science Ltd; Journal of Theoretical Biology; 373; 5-2015; 73-81
0022-5193
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jtbi.2015.03.015
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0022519315001241
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Ltd - Elsevier Science Ltd
publisher.none.fl_str_mv Academic Press Ltd - Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799195772983443456
score 15.812429

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