Effects of natural antioxidants in neurodegenerative disease

Polyphenols are secondary metabolites with antioxidant properties and are abundant in the diet. Fruits, vegetables, herbs, and various drinks (tea, wine, and juices) are all sources of these molecules. Despite their abundance, investigations into the benefits of polyphenols in human health have only...

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Autores: Albarracin, Sonia Luz, Stab, Ben, Casas, Zulma, Sutachan, Jhon Jairo, Samudio, Ismael, Gonzalez, Janneth, Gonzalo, Luis, Capani, Francisco, Morales, Ludis, Barreto, George E.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/67495
Acceso en línea:http://hdl.handle.net/11336/67495
Access Level:acceso abierto
Palabra clave:Alzheimer'S Disease
Amyotrophic Lateral Sclerosis
Antioxidants
Brain Aging
Neuroprotection
Oxidative Stress
Parkinson'S Disease
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
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spelling Effects of natural antioxidants in neurodegenerative diseaseAlbarracin, Sonia LuzStab, BenCasas, ZulmaSutachan, Jhon JairoSamudio, IsmaelGonzalez, JannethGonzalo, LuisCapani, FranciscoMorales, LudisBarreto, George E.Alzheimer'S DiseaseAmyotrophic Lateral SclerosisAntioxidantsBrain AgingNeuroprotectionOxidative StressParkinson'S Diseasehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Polyphenols are secondary metabolites with antioxidant properties and are abundant in the diet. Fruits, vegetables, herbs, and various drinks (tea, wine, and juices) are all sources of these molecules. Despite their abundance, investigations into the benefits of polyphenols in human health have only recently begun. Phenolic compounds have received increasing interest because of numerous epidemiological studies. These studies have suggested associations between the consumption of polyphenol-rich aliments and the prevention of chronic diseases, such as cancer, cardiovascular diseases, and neurodegenerative diseases. More specifically, in the last 10 years literature on the neuroprotective effects of a polyphenol-rich diet has grown considerably. It has been demonstrated, in various cell culture and animal models, that these metabolites are able to protect neuronal cells by attenuating oxidative stress and damage. However, it remains unclear as to how these compounds reach the brain, what concentrations are necessary, and what biologically active forms are needed to exert beneficial effects. Therefore, further research is needed to identify the molecular pathways and intracellular targets responsible for polyphenol's neuroprotective effects. The aim of this paper is to present various well-known dietary polyphenols and their mechanisms of neuroprotection with an emphasis on Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. © W.S. Maney & Son Ltd 2012.Fil: Albarracin, Sonia Luz. Pontificia Universidad Javeriana; ColombiaFil: Stab, Ben. Pontificia Universidad Javeriana; ColombiaFil: Casas, Zulma. Pontificia Universidad Javeriana; ColombiaFil: Sutachan, Jhon Jairo. Pontificia Universidad Javeriana; ColombiaFil: Samudio, Ismael. Pontificia Universidad Javeriana; ColombiaFil: Gonzalez, Janneth. Pontificia Universidad Javeriana; ColombiaFil: Gonzalo, Luis. Pontificia Universidad Javeriana; ColombiaFil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Universidad Argentina "John F. Kennedy"; ArgentinaFil: Morales, Ludis. Pontificia Universidad Javeriana; ColombiaFil: Barreto, George E.. Pontificia Universidad Javeriana; ColombiaManey Publishing2012-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67495Albarracin, Sonia Luz; Stab, Ben; Casas, Zulma; Sutachan, Jhon Jairo; Samudio, Ismael; et al.; Effects of natural antioxidants in neurodegenerative disease; Maney Publishing; Nutritional Neuroscience; 15; 1; 1-2012; 1-91028-415XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1179/1476830511Y.0000000028info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1179/1476830511Y.0000000028info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:56:04Zoai:ri.conicet.gov.ar:11336/67495instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:56:04.387CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effects of natural antioxidants in neurodegenerative disease
title Effects of natural antioxidants in neurodegenerative disease
spellingShingle Effects of natural antioxidants in neurodegenerative disease
Albarracin, Sonia Luz
Alzheimer'S Disease
Amyotrophic Lateral Sclerosis
Antioxidants
Brain Aging
Neuroprotection
Oxidative Stress
Parkinson'S Disease
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
title_short Effects of natural antioxidants in neurodegenerative disease
title_full Effects of natural antioxidants in neurodegenerative disease
title_fullStr Effects of natural antioxidants in neurodegenerative disease
title_full_unstemmed Effects of natural antioxidants in neurodegenerative disease
title_sort Effects of natural antioxidants in neurodegenerative disease
dc.creator.none.fl_str_mv Albarracin, Sonia Luz
Stab, Ben
Casas, Zulma
Sutachan, Jhon Jairo
Samudio, Ismael
Gonzalez, Janneth
Gonzalo, Luis
Capani, Francisco
Morales, Ludis
Barreto, George E.
author Albarracin, Sonia Luz
author_facet Albarracin, Sonia Luz
Stab, Ben
Casas, Zulma
Sutachan, Jhon Jairo
Samudio, Ismael
Gonzalez, Janneth
Gonzalo, Luis
Capani, Francisco
Morales, Ludis
Barreto, George E.
author_role author
author2 Stab, Ben
Casas, Zulma
Sutachan, Jhon Jairo
Samudio, Ismael
Gonzalez, Janneth
Gonzalo, Luis
Capani, Francisco
Morales, Ludis
Barreto, George E.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Alzheimer'S Disease
Amyotrophic Lateral Sclerosis
Antioxidants
Brain Aging
Neuroprotection
Oxidative Stress
Parkinson'S Disease
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
topic Alzheimer'S Disease
Amyotrophic Lateral Sclerosis
Antioxidants
Brain Aging
Neuroprotection
Oxidative Stress
Parkinson'S Disease
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
description Polyphenols are secondary metabolites with antioxidant properties and are abundant in the diet. Fruits, vegetables, herbs, and various drinks (tea, wine, and juices) are all sources of these molecules. Despite their abundance, investigations into the benefits of polyphenols in human health have only recently begun. Phenolic compounds have received increasing interest because of numerous epidemiological studies. These studies have suggested associations between the consumption of polyphenol-rich aliments and the prevention of chronic diseases, such as cancer, cardiovascular diseases, and neurodegenerative diseases. More specifically, in the last 10 years literature on the neuroprotective effects of a polyphenol-rich diet has grown considerably. It has been demonstrated, in various cell culture and animal models, that these metabolites are able to protect neuronal cells by attenuating oxidative stress and damage. However, it remains unclear as to how these compounds reach the brain, what concentrations are necessary, and what biologically active forms are needed to exert beneficial effects. Therefore, further research is needed to identify the molecular pathways and intracellular targets responsible for polyphenol's neuroprotective effects. The aim of this paper is to present various well-known dietary polyphenols and their mechanisms of neuroprotection with an emphasis on Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. © W.S. Maney & Son Ltd 2012.
publishDate 2012
dc.date.none.fl_str_mv 2012-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67495
Albarracin, Sonia Luz; Stab, Ben; Casas, Zulma; Sutachan, Jhon Jairo; Samudio, Ismael; et al.; Effects of natural antioxidants in neurodegenerative disease; Maney Publishing; Nutritional Neuroscience; 15; 1; 1-2012; 1-9
1028-415X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67495
identifier_str_mv Albarracin, Sonia Luz; Stab, Ben; Casas, Zulma; Sutachan, Jhon Jairo; Samudio, Ismael; et al.; Effects of natural antioxidants in neurodegenerative disease; Maney Publishing; Nutritional Neuroscience; 15; 1; 1-2012; 1-9
1028-415X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1179/1476830511Y.0000000028
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1179/1476830511Y.0000000028
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Maney Publishing
publisher.none.fl_str_mv Maney Publishing
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 15.811543

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