Interactions of rutin with the oxidovanadium( iv ) cation. Anticancer improvement effects of glycosylated flavonoids

This work reports the biological evaluation of the new complex Na2[VO(rut)(OH)2]·5H2O (rut = rutin, a glycosylated flavonoid). The complex was different in its coordination mode (catechol-like) from those previously reported, [VO(rutin)(H2O)2]2(SO4)·4H2O and [VO(rut)2]·4H2O (acetylacetonate-like coo...

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Authors: Goitia Semeco, Helen Rosmary, Quispe Castillo, Patricia Araceli, Naso, Luciana Gissella, Martínez, Valeria R., Rey, Marilin, Rizzi, Alberto C., Ferrer, Evelina Gloria, Williams, Patricia Ana María
Format: article
Status:Published version
Publication Date:2019
Country:Argentina
Institution:Consejo Nacional de Investigaciones Científicas y Técnicas
Repository:CONICET Digital (CONICET)
Language:English
OAI Identifier:oai:ri.conicet.gov.ar:11336/124943
Online Access:http://hdl.handle.net/11336/124943
Access Level:Open access
Keyword:RUTIN
COMPLEX
ANTICANCER
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
id AR_d80eff455706841bafa4e288e2299c1f
oai_identifier_str oai:ri.conicet.gov.ar:11336/124943
network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Interactions of rutin with the oxidovanadium( iv ) cation. Anticancer improvement effects of glycosylated flavonoids
title Interactions of rutin with the oxidovanadium( iv ) cation. Anticancer improvement effects of glycosylated flavonoids
spellingShingle Interactions of rutin with the oxidovanadium( iv ) cation. Anticancer improvement effects of glycosylated flavonoids
Goitia Semeco, Helen Rosmary
RUTIN
COMPLEX
ANTICANCER
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
title_short Interactions of rutin with the oxidovanadium( iv ) cation. Anticancer improvement effects of glycosylated flavonoids
title_full Interactions of rutin with the oxidovanadium( iv ) cation. Anticancer improvement effects of glycosylated flavonoids
title_fullStr Interactions of rutin with the oxidovanadium( iv ) cation. Anticancer improvement effects of glycosylated flavonoids
title_full_unstemmed Interactions of rutin with the oxidovanadium( iv ) cation. Anticancer improvement effects of glycosylated flavonoids
title_sort Interactions of rutin with the oxidovanadium( iv ) cation. Anticancer improvement effects of glycosylated flavonoids
dc.creator.none.fl_str_mv Goitia Semeco, Helen Rosmary
Quispe Castillo, Patricia Araceli
Naso, Luciana Gissella
Martínez, Valeria R.
Rey, Marilin
Rizzi, Alberto C.
Ferrer, Evelina Gloria
Williams, Patricia Ana María
author Goitia Semeco, Helen Rosmary
author_facet Goitia Semeco, Helen Rosmary
Quispe Castillo, Patricia Araceli
Naso, Luciana Gissella
Martínez, Valeria R.
Rey, Marilin
Rizzi, Alberto C.
Ferrer, Evelina Gloria
Williams, Patricia Ana María
author_role author
author2 Quispe Castillo, Patricia Araceli
Naso, Luciana Gissella
Martínez, Valeria R.
Rey, Marilin
Rizzi, Alberto C.
Ferrer, Evelina Gloria
Williams, Patricia Ana María
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv RUTIN
COMPLEX
ANTICANCER
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
topic RUTIN
COMPLEX
ANTICANCER
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
description This work reports the biological evaluation of the new complex Na2[VO(rut)(OH)2]·5H2O (rut = rutin, a glycosylated flavonoid). The complex was different in its coordination mode (catechol-like) from those previously reported, [VO(rutin)(H2O)2]2(SO4)·4H2O and [VO(rut)2]·4H2O (acetylacetonate-like coordination). Due to the coordination mode, the complex only improved the antioxidant activity of the ligand against superoxide and hydroxyl radicals. The results show that while both 100 µM rutin and V(IV)O did not exhibit cytotoxic activity on A549 cells, the complex selectively improved the anticancer effect (IC50 = 95 µM), cellular reactive oxygen species (ROS) generation and depletion of the non-enzymatic antioxidant glutathione (GSH), producing oxidized glutathione (GSSG), and it did not affect the viability of the normal embryonic lung cell line (MRC-5) (up to 100 µM). All these data, and given the reversion of the cell killing effect of the complex upon treatment with the antioxidant agent N-acetyl-L-cysteine (NAC), suggested an oxidative stress mechanism. Rutin and VOrut can spontaneously bind bovine serum albumin (BSA) and they can be stored and transported by the protein.
publishDate 2019
dc.date.none.fl_str_mv 2019-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/124943
Goitia Semeco, Helen Rosmary; Quispe Castillo, Patricia Araceli; Naso, Luciana Gissella; Martínez, Valeria R.; Rey, Marilin; et al.; Interactions of rutin with the oxidovanadium( iv ) cation. Anticancer improvement effects of glycosylated flavonoids; Royal Society of Chemistry; New Journal of Chemistry; 6-2019; 1-11
1144-0546
CONICET Digital
CONICET
url http://hdl.handle.net/11336/124943
identifier_str_mv Goitia Semeco, Helen Rosmary; Quispe Castillo, Patricia Araceli; Naso, Luciana Gissella; Martínez, Valeria R.; Rey, Marilin; et al.; Interactions of rutin with the oxidovanadium( iv ) cation. Anticancer improvement effects of glycosylated flavonoids; Royal Society of Chemistry; New Journal of Chemistry; 6-2019; 1-11
1144-0546
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://xlink.rsc.org/?DOI=C9NJ01039D
info:eu-repo/semantics/altIdentifier/doi/10.1039/c9nj01039d
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799195517081616384
spelling Interactions of rutin with the oxidovanadium( iv ) cation. Anticancer improvement effects of glycosylated flavonoidsGoitia Semeco, Helen RosmaryQuispe Castillo, Patricia AraceliNaso, Luciana GissellaMartínez, Valeria R.Rey, MarilinRizzi, Alberto C.Ferrer, Evelina GloriaWilliams, Patricia Ana MaríaRUTINCOMPLEXANTICANCERhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1This work reports the biological evaluation of the new complex Na2[VO(rut)(OH)2]·5H2O (rut = rutin, a glycosylated flavonoid). The complex was different in its coordination mode (catechol-like) from those previously reported, [VO(rutin)(H2O)2]2(SO4)·4H2O and [VO(rut)2]·4H2O (acetylacetonate-like coordination). Due to the coordination mode, the complex only improved the antioxidant activity of the ligand against superoxide and hydroxyl radicals. The results show that while both 100 µM rutin and V(IV)O did not exhibit cytotoxic activity on A549 cells, the complex selectively improved the anticancer effect (IC50 = 95 µM), cellular reactive oxygen species (ROS) generation and depletion of the non-enzymatic antioxidant glutathione (GSH), producing oxidized glutathione (GSSG), and it did not affect the viability of the normal embryonic lung cell line (MRC-5) (up to 100 µM). All these data, and given the reversion of the cell killing effect of the complex upon treatment with the antioxidant agent N-acetyl-L-cysteine (NAC), suggested an oxidative stress mechanism. Rutin and VOrut can spontaneously bind bovine serum albumin (BSA) and they can be stored and transported by the protein.Fil: Goitia Semeco, Helen Rosmary. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: Quispe Castillo, Patricia Araceli. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: Naso, Luciana Gissella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: Martínez, Valeria R.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: Rey, Marilin. Universidad Nacional del Litoral; ArgentinaFil: Rizzi, Alberto C.. Universidad Nacional del Litoral; ArgentinaFil: Ferrer, Evelina Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaRoyal Society of Chemistry2019-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/124943Goitia Semeco, Helen Rosmary; Quispe Castillo, Patricia Araceli; Naso, Luciana Gissella; Martínez, Valeria R.; Rey, Marilin; et al.; Interactions of rutin with the oxidovanadium( iv ) cation. Anticancer improvement effects of glycosylated flavonoids; Royal Society of Chemistry; New Journal of Chemistry; 6-2019; 1-111144-0546CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://xlink.rsc.org/?DOI=C9NJ01039Dinfo:eu-repo/semantics/altIdentifier/doi/10.1039/c9nj01039dinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:54:58Zoai:ri.conicet.gov.ar:11336/124943instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:54:58.341CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
score 15.812429

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