Molecular and cellular mechanisms involved in the Trypanosoma cruzi/host cell interplay

The protozoan parasite Trypanosoma cruzi has a complex biological cycle that involves vertebrate and invertebrate hosts. In mammals, the infective trypomastigote form of this parasite can invade several cell types by exploiting phagocytic-like or non-phagocytic mechanisms depending on the class of c...

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Detalles Bibliográficos
Autores: Romano, Patricia Silvia, Cueto, Juan Agustin, Casassa, Ana Florencia, Vanrell, Maria Cristina, Gottlieb, Roberta A., Colombo, Maria Isabel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/147643
Acceso en línea:http://hdl.handle.net/11336/147643
Access Level:acceso abierto
Palabra clave:AUTOPHAGOSOME
AUTOPHAGY
LC3
LYSOSOMES
PLASMA MEMBRANE
TRYPANOSOMA CRUZI
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
id AR_d4bc0915c7e863db4e8e7e06a21aa807
oai_identifier_str oai:ri.conicet.gov.ar:11336/147643
network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Molecular and cellular mechanisms involved in the Trypanosoma cruzi/host cell interplay
title Molecular and cellular mechanisms involved in the Trypanosoma cruzi/host cell interplay
spellingShingle Molecular and cellular mechanisms involved in the Trypanosoma cruzi/host cell interplay
Romano, Patricia Silvia
AUTOPHAGOSOME
AUTOPHAGY
LC3
LYSOSOMES
PLASMA MEMBRANE
TRYPANOSOMA CRUZI
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
title_short Molecular and cellular mechanisms involved in the Trypanosoma cruzi/host cell interplay
title_full Molecular and cellular mechanisms involved in the Trypanosoma cruzi/host cell interplay
title_fullStr Molecular and cellular mechanisms involved in the Trypanosoma cruzi/host cell interplay
title_full_unstemmed Molecular and cellular mechanisms involved in the Trypanosoma cruzi/host cell interplay
title_sort Molecular and cellular mechanisms involved in the Trypanosoma cruzi/host cell interplay
dc.creator.none.fl_str_mv Romano, Patricia Silvia
Cueto, Juan Agustin
Casassa, Ana Florencia
Vanrell, Maria Cristina
Gottlieb, Roberta A.
Colombo, Maria Isabel
author Romano, Patricia Silvia
author_facet Romano, Patricia Silvia
Cueto, Juan Agustin
Casassa, Ana Florencia
Vanrell, Maria Cristina
Gottlieb, Roberta A.
Colombo, Maria Isabel
author_role author
author2 Cueto, Juan Agustin
Casassa, Ana Florencia
Vanrell, Maria Cristina
Gottlieb, Roberta A.
Colombo, Maria Isabel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv AUTOPHAGOSOME
AUTOPHAGY
LC3
LYSOSOMES
PLASMA MEMBRANE
TRYPANOSOMA CRUZI
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
topic AUTOPHAGOSOME
AUTOPHAGY
LC3
LYSOSOMES
PLASMA MEMBRANE
TRYPANOSOMA CRUZI
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
description The protozoan parasite Trypanosoma cruzi has a complex biological cycle that involves vertebrate and invertebrate hosts. In mammals, the infective trypomastigote form of this parasite can invade several cell types by exploiting phagocytic-like or non-phagocytic mechanisms depending on the class of cell involved. Morphological studies showed that when trypomastigotes contact macrophages, they induce the formation of plasma membrane protrusions that differ from the canonical phagocytosis that occurs in the case of noninfective epimastigotes. In contrast, when trypomastigotes infect epithelial or muscle cells, the cell surface is minimally modified, suggesting the induction of a different class of process. Lysosomal-dependent or -independent T. cruzi invasion of host cells are two different models that describe the molecular and cellular events activated during parasite entry into nonphagocytic cells. In this context, we have previously shown that induction of autophagy in host cells before infection favors T. cruzi invasion. Furthermore, we demonstrate that autophagosomes and the autophagosomal protein LC3 are recruited to the T. cruzi entry sites and that the newly formed T. cruzi parasitophorous vacuole has characteristics of an autophagolysosome. This review summarizes the current knowledge of the molecular and cellular mechanisms of T. cruzi invasion in nonphagocytic cells. Based on our findings, we propose a new model in which T. cruzi takes advantage of the upregulation of autophagy during starvation to increase its successful colonization of host cells.
publishDate 2012
dc.date.none.fl_str_mv 2012-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/147643
Romano, Patricia Silvia; Cueto, Juan Agustin; Casassa, Ana Florencia; Vanrell, Maria Cristina; Gottlieb, Roberta A.; et al.; Molecular and cellular mechanisms involved in the Trypanosoma cruzi/host cell interplay; John Wiley & Sons Inc; IUBMB Life; 64; 5; 5-2012; 387-396
1521-6543
CONICET Digital
CONICET
url http://hdl.handle.net/11336/147643
identifier_str_mv Romano, Patricia Silvia; Cueto, Juan Agustin; Casassa, Ana Florencia; Vanrell, Maria Cristina; Gottlieb, Roberta A.; et al.; Molecular and cellular mechanisms involved in the Trypanosoma cruzi/host cell interplay; John Wiley & Sons Inc; IUBMB Life; 64; 5; 5-2012; 387-396
1521-6543
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/iub.1019
info:eu-repo/semantics/altIdentifier/url/https://iubmb.onlinelibrary.wiley.com/doi/10.1002/iub.1019
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons Inc
publisher.none.fl_str_mv John Wiley & Sons Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799195965580640256
spelling Molecular and cellular mechanisms involved in the Trypanosoma cruzi/host cell interplayRomano, Patricia SilviaCueto, Juan AgustinCasassa, Ana FlorenciaVanrell, Maria CristinaGottlieb, Roberta A.Colombo, Maria IsabelAUTOPHAGOSOMEAUTOPHAGYLC3LYSOSOMESPLASMA MEMBRANETRYPANOSOMA CRUZIhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The protozoan parasite Trypanosoma cruzi has a complex biological cycle that involves vertebrate and invertebrate hosts. In mammals, the infective trypomastigote form of this parasite can invade several cell types by exploiting phagocytic-like or non-phagocytic mechanisms depending on the class of cell involved. Morphological studies showed that when trypomastigotes contact macrophages, they induce the formation of plasma membrane protrusions that differ from the canonical phagocytosis that occurs in the case of noninfective epimastigotes. In contrast, when trypomastigotes infect epithelial or muscle cells, the cell surface is minimally modified, suggesting the induction of a different class of process. Lysosomal-dependent or -independent T. cruzi invasion of host cells are two different models that describe the molecular and cellular events activated during parasite entry into nonphagocytic cells. In this context, we have previously shown that induction of autophagy in host cells before infection favors T. cruzi invasion. Furthermore, we demonstrate that autophagosomes and the autophagosomal protein LC3 are recruited to the T. cruzi entry sites and that the newly formed T. cruzi parasitophorous vacuole has characteristics of an autophagolysosome. This review summarizes the current knowledge of the molecular and cellular mechanisms of T. cruzi invasion in nonphagocytic cells. Based on our findings, we propose a new model in which T. cruzi takes advantage of the upregulation of autophagy during starvation to increase its successful colonization of host cells.Fil: Romano, Patricia Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología; ArgentinaFil: Cueto, Juan Agustin. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Casassa, Ana Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología; ArgentinaFil: Vanrell, Maria Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Gottlieb, Roberta A.. San Diego State University; Estados UnidosFil: Colombo, Maria Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaJohn Wiley & Sons Inc2012-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/147643Romano, Patricia Silvia; Cueto, Juan Agustin; Casassa, Ana Florencia; Vanrell, Maria Cristina; Gottlieb, Roberta A.; et al.; Molecular and cellular mechanisms involved in the Trypanosoma cruzi/host cell interplay; John Wiley & Sons Inc; IUBMB Life; 64; 5; 5-2012; 387-3961521-6543CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/iub.1019info:eu-repo/semantics/altIdentifier/url/https://iubmb.onlinelibrary.wiley.com/doi/10.1002/iub.1019info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:10:04Zoai:ri.conicet.gov.ar:11336/147643instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:10:04.317CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
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