Virulence factors of the mycobacterium tuberculosis complex

The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that cause tuberculosis in both humans and animals. This illness, still today, remains to be one of the leading causes of morbidity and mortality throughout the world. The mycobacteria enter the host by air, and, once...

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Autores: Forrellad, Marina Andrea, Klepp, Laura Ines, Gioffré, Andrea Karina, Sabio y García, Julia Verónica, Morbidoni, Héctor Ricardo, Santangelo, María de la Paz, Cataldi, Ángel Adrián, Bigi, Fabiana
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/197357
Acceso en línea:http://hdl.handle.net/11336/197357
Access Level:acceso abierto
Palabra clave:MYCOBACTERIUM TUBERCULOSIS
PATHOGEN
VIRULENCE
VIRULENCE FACTORS
VIRULENCE GENES
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
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network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Virulence factors of the mycobacterium tuberculosis complex
title Virulence factors of the mycobacterium tuberculosis complex
spellingShingle Virulence factors of the mycobacterium tuberculosis complex
Forrellad, Marina Andrea
MYCOBACTERIUM TUBERCULOSIS
PATHOGEN
VIRULENCE
VIRULENCE FACTORS
VIRULENCE GENES
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
title_short Virulence factors of the mycobacterium tuberculosis complex
title_full Virulence factors of the mycobacterium tuberculosis complex
title_fullStr Virulence factors of the mycobacterium tuberculosis complex
title_full_unstemmed Virulence factors of the mycobacterium tuberculosis complex
title_sort Virulence factors of the mycobacterium tuberculosis complex
dc.creator.none.fl_str_mv Forrellad, Marina Andrea
Klepp, Laura Ines
Gioffré, Andrea Karina
Sabio y García, Julia Verónica
Morbidoni, Héctor Ricardo
Santangelo, María de la Paz
Cataldi, Ángel Adrián
Bigi, Fabiana
author Forrellad, Marina Andrea
author_facet Forrellad, Marina Andrea
Klepp, Laura Ines
Gioffré, Andrea Karina
Sabio y García, Julia Verónica
Morbidoni, Héctor Ricardo
Santangelo, María de la Paz
Cataldi, Ángel Adrián
Bigi, Fabiana
author_role author
author2 Klepp, Laura Ines
Gioffré, Andrea Karina
Sabio y García, Julia Verónica
Morbidoni, Héctor Ricardo
Santangelo, María de la Paz
Cataldi, Ángel Adrián
Bigi, Fabiana
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv MYCOBACTERIUM TUBERCULOSIS
PATHOGEN
VIRULENCE
VIRULENCE FACTORS
VIRULENCE GENES
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
topic MYCOBACTERIUM TUBERCULOSIS
PATHOGEN
VIRULENCE
VIRULENCE FACTORS
VIRULENCE GENES
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
description The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that cause tuberculosis in both humans and animals. This illness, still today, remains to be one of the leading causes of morbidity and mortality throughout the world. The mycobacteria enter the host by air, and, once in the lungs, are phagocytated by macrophages. This may lead to the rapid elimination of the bacillus or to the triggering of an active tuberculosis infection. A large number of different virulence factors have evolved in MTBC members as a response to the host immune reaction. The aim of this review is to describe the bacterial genes/proteins that are essential for the virulence of MTBC species, and that have been demonstrated in an in vivo model of infection. Knowledge of MTBC virulence factors is essential for the development of new vaccines and drugs to help manage the disease toward an increasingly more tuberculosis-free world. Introduction.
publishDate 2012
dc.date.none.fl_str_mv 2012-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/197357
Forrellad, Marina Andrea; Klepp, Laura Ines; Gioffré, Andrea Karina; Sabio y García, Julia Verónica; Morbidoni, Héctor Ricardo; et al.; Virulence factors of the mycobacterium tuberculosis complex; Taylor & Francis; Virulence; 4; 1; 10-2012; 3-66
2150-5608
CONICET Digital
CONICET
url http://hdl.handle.net/11336/197357
identifier_str_mv Forrellad, Marina Andrea; Klepp, Laura Ines; Gioffré, Andrea Karina; Sabio y García, Julia Verónica; Morbidoni, Héctor Ricardo; et al.; Virulence factors of the mycobacterium tuberculosis complex; Taylor & Francis; Virulence; 4; 1; 10-2012; 3-66
2150-5608
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.4161/viru.22329
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.4161/viru.22329
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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spelling Virulence factors of the mycobacterium tuberculosis complexForrellad, Marina AndreaKlepp, Laura InesGioffré, Andrea KarinaSabio y García, Julia VerónicaMorbidoni, Héctor RicardoSantangelo, María de la PazCataldi, Ángel AdriánBigi, FabianaMYCOBACTERIUM TUBERCULOSISPATHOGENVIRULENCEVIRULENCE FACTORSVIRULENCE GENEShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that cause tuberculosis in both humans and animals. This illness, still today, remains to be one of the leading causes of morbidity and mortality throughout the world. The mycobacteria enter the host by air, and, once in the lungs, are phagocytated by macrophages. This may lead to the rapid elimination of the bacillus or to the triggering of an active tuberculosis infection. A large number of different virulence factors have evolved in MTBC members as a response to the host immune reaction. The aim of this review is to describe the bacterial genes/proteins that are essential for the virulence of MTBC species, and that have been demonstrated in an in vivo model of infection. Knowledge of MTBC virulence factors is essential for the development of new vaccines and drugs to help manage the disease toward an increasingly more tuberculosis-free world. Introduction.Fil: Forrellad, Marina Andrea. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Klepp, Laura Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; ArgentinaFil: Gioffré, Andrea Karina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; ArgentinaFil: Sabio y García, Julia Verónica. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; ArgentinaFil: Morbidoni, Héctor Ricardo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Escuela de Ciencias Médicas. Cátedra de Microbiología, Parasitología y Virología; ArgentinaFil: Santangelo, María de la Paz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; ArgentinaFil: Cataldi, Ángel Adrián. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaTaylor & Francis2012-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/197357Forrellad, Marina Andrea; Klepp, Laura Ines; Gioffré, Andrea Karina; Sabio y García, Julia Verónica; Morbidoni, Héctor Ricardo; et al.; Virulence factors of the mycobacterium tuberculosis complex; Taylor & Francis; Virulence; 4; 1; 10-2012; 3-662150-5608CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.4161/viru.22329info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.4161/viru.22329info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:38:58Zoai:ri.conicet.gov.ar:11336/197357instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:38:59.1CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
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