Novel therapeutic targets for arenavirus hemorrhagic fevers

Several members of the family Arenaviridae can cause severe hemorrhagic fevers in humans, representing a serious public health problem in endemic areas of Africa and South America. The Lassa virus is the most prevalent and dangerous arenavirus, causing over 300,000 infections per year and several th...

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Detalles Bibliográficos
Autores: Garcia, Cybele, Sepúlveda, Claudia Soledad, Damonte, Elsa Beatriz
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2011
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/66763
Acceso en línea:http://hdl.handle.net/11336/66763
Access Level:acceso abierto
Palabra clave:Antiviral Agent
Arenavirus
Junin Virus
Lassa Virus
Therapeutic Target
Viral Hemorrhagic Fevers
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
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spelling Novel therapeutic targets for arenavirus hemorrhagic feversGarcia, CybeleSepúlveda, Claudia SoledadDamonte, Elsa BeatrizAntiviral AgentArenavirusJunin VirusLassa VirusTherapeutic TargetViral Hemorrhagic Fevershttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Several members of the family Arenaviridae can cause severe hemorrhagic fevers in humans, representing a serious public health problem in endemic areas of Africa and South America. The Lassa virus is the most prevalent and dangerous arenavirus, causing over 300,000 infections per year and several thousand deaths. Furthermore, pathogenic arenaviruses are considered as category A potential agents for bioterrorism. Based on the danger of arenaviruses for human health, the increased emergence of new viral species in recent years and the lack of effective tools for their control or prevention, the search for novel antiviral compounds effective against these pathogenic agents is a continuous demanding effort. This article focuses on novel strategies to identify inhibitors for arenavirus therapy, analyzing viral and host proteins essential for virus infection as potential targets for antiviral development. © 2011 Future Medicine Ltd.Fil: Garcia, Cybele. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; ArgentinaFil: Sepúlveda, Claudia Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; ArgentinaFil: Damonte, Elsa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; ArgentinaFuture Medicine2011-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/66763Garcia, Cybele; Sepúlveda, Claudia Soledad; Damonte, Elsa Beatriz; Novel therapeutic targets for arenavirus hemorrhagic fevers; Future Medicine; Future Virology; 6; 1; 1-2011; 27-441746-0794CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.futuremedicine.com/doi/10.2217/fvl.10.65info:eu-repo/semantics/altIdentifier/doi/10.2217/fvl.10.65info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:10:00Zoai:ri.conicet.gov.ar:11336/66763instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:10:00.629CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Novel therapeutic targets for arenavirus hemorrhagic fevers
title Novel therapeutic targets for arenavirus hemorrhagic fevers
spellingShingle Novel therapeutic targets for arenavirus hemorrhagic fevers
Garcia, Cybele
Antiviral Agent
Arenavirus
Junin Virus
Lassa Virus
Therapeutic Target
Viral Hemorrhagic Fevers
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
title_short Novel therapeutic targets for arenavirus hemorrhagic fevers
title_full Novel therapeutic targets for arenavirus hemorrhagic fevers
title_fullStr Novel therapeutic targets for arenavirus hemorrhagic fevers
title_full_unstemmed Novel therapeutic targets for arenavirus hemorrhagic fevers
title_sort Novel therapeutic targets for arenavirus hemorrhagic fevers
dc.creator.none.fl_str_mv Garcia, Cybele
Sepúlveda, Claudia Soledad
Damonte, Elsa Beatriz
author Garcia, Cybele
author_facet Garcia, Cybele
Sepúlveda, Claudia Soledad
Damonte, Elsa Beatriz
author_role author
author2 Sepúlveda, Claudia Soledad
Damonte, Elsa Beatriz
author2_role author
author
dc.subject.none.fl_str_mv Antiviral Agent
Arenavirus
Junin Virus
Lassa Virus
Therapeutic Target
Viral Hemorrhagic Fevers
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
topic Antiviral Agent
Arenavirus
Junin Virus
Lassa Virus
Therapeutic Target
Viral Hemorrhagic Fevers
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
description Several members of the family Arenaviridae can cause severe hemorrhagic fevers in humans, representing a serious public health problem in endemic areas of Africa and South America. The Lassa virus is the most prevalent and dangerous arenavirus, causing over 300,000 infections per year and several thousand deaths. Furthermore, pathogenic arenaviruses are considered as category A potential agents for bioterrorism. Based on the danger of arenaviruses for human health, the increased emergence of new viral species in recent years and the lack of effective tools for their control or prevention, the search for novel antiviral compounds effective against these pathogenic agents is a continuous demanding effort. This article focuses on novel strategies to identify inhibitors for arenavirus therapy, analyzing viral and host proteins essential for virus infection as potential targets for antiviral development. © 2011 Future Medicine Ltd.
publishDate 2011
dc.date.none.fl_str_mv 2011-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/66763
Garcia, Cybele; Sepúlveda, Claudia Soledad; Damonte, Elsa Beatriz; Novel therapeutic targets for arenavirus hemorrhagic fevers; Future Medicine; Future Virology; 6; 1; 1-2011; 27-44
1746-0794
CONICET Digital
CONICET
url http://hdl.handle.net/11336/66763
identifier_str_mv Garcia, Cybele; Sepúlveda, Claudia Soledad; Damonte, Elsa Beatriz; Novel therapeutic targets for arenavirus hemorrhagic fevers; Future Medicine; Future Virology; 6; 1; 1-2011; 27-44
1746-0794
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.futuremedicine.com/doi/10.2217/fvl.10.65
info:eu-repo/semantics/altIdentifier/doi/10.2217/fvl.10.65
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Future Medicine
publisher.none.fl_str_mv Future Medicine
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 15,811543

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