Epstein Barr virus in relation to apoptosis markers and patients' outcome in pediatric B-cell Non-Hodgkin lymphoma

In this study, we investigated Epstein Barr virus (EBV) presence, associated to proliferation and apoptosis proteins in pediatric B-cell Non-Hodgkin lymphoma (B-NHL). EBERs, Ki67, active caspase 3, Bax and Bcl2 were analyzed on B-NHL tissue from 40 patients. Forty percent showed EBV expression, sign...

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Autores: Chabay, Paola Andrea, Lara, María Julia, Lorenzetti, Mario Alejandro, Cambra, P., Acosta Haab, G., Aversa, L., de Matteo, Elena Noemí, Preciado, María Victoria
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2011
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/192110
Acceso en línea:http://hdl.handle.net/11336/192110
Access Level:acceso abierto
Palabra clave:APOPTOSIS
EPSTEIN BARR VIRUS
PEDIATRIC B-CELL NON-HODGKIN LYMPHOMA
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
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network_acronym_str AR
network_name_str Argentina
repository_id_str
spelling Epstein Barr virus in relation to apoptosis markers and patients' outcome in pediatric B-cell Non-Hodgkin lymphomaChabay, Paola AndreaLara, María JuliaLorenzetti, Mario AlejandroCambra, P.Acosta Haab, G.Aversa, L.de Matteo, Elena NoemíPreciado, María VictoriaAPOPTOSISEPSTEIN BARR VIRUSPEDIATRIC B-CELL NON-HODGKIN LYMPHOMAhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3In this study, we investigated Epstein Barr virus (EBV) presence, associated to proliferation and apoptosis proteins in pediatric B-cell Non-Hodgkin lymphoma (B-NHL). EBERs, Ki67, active caspase 3, Bax and Bcl2 were analyzed on B-NHL tissue from 40 patients. Forty percent showed EBV expression, significantly higher among patients ≤10. years (P= 0.027), and associated with immunosuppression (P= 0.020), but not associated apotosis markers. However, EBV was associated with a worse event-free survival (P= 0.016), particularly under immunosuppression. Even though EBV did not seem to alter apoptotic pathways, it exhibited survival disadvantage and could be an important cofactor in B-cell lymphomagenesis in younger children.Fil: Chabay, Paola Andrea. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Lara, María Julia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; ArgentinaFil: Lorenzetti, Mario Alejandro. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cambra, P.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; ArgentinaFil: Acosta Haab, G.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; ArgentinaFil: Aversa, L.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; ArgentinaFil: de Matteo, Elena Noemí. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Preciado, María Victoria. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier Ireland2011-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/192110Chabay, Paola Andrea; Lara, María Julia; Lorenzetti, Mario Alejandro; Cambra, P.; Acosta Haab, G.; et al.; Epstein Barr virus in relation to apoptosis markers and patients' outcome in pediatric B-cell Non-Hodgkin lymphoma; Elsevier Ireland; Cancer Letters; 307; 2; 8-2011; 221-2260304-3835CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0304383511002060info:eu-repo/semantics/altIdentifier/doi/10.1016/j.canlet.2011.04.006info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:49:23Zoai:ri.conicet.gov.ar:11336/192110instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:49:23.391CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Epstein Barr virus in relation to apoptosis markers and patients' outcome in pediatric B-cell Non-Hodgkin lymphoma
title Epstein Barr virus in relation to apoptosis markers and patients' outcome in pediatric B-cell Non-Hodgkin lymphoma
spellingShingle Epstein Barr virus in relation to apoptosis markers and patients' outcome in pediatric B-cell Non-Hodgkin lymphoma
Chabay, Paola Andrea
APOPTOSIS
EPSTEIN BARR VIRUS
PEDIATRIC B-CELL NON-HODGKIN LYMPHOMA
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
title_short Epstein Barr virus in relation to apoptosis markers and patients' outcome in pediatric B-cell Non-Hodgkin lymphoma
title_full Epstein Barr virus in relation to apoptosis markers and patients' outcome in pediatric B-cell Non-Hodgkin lymphoma
title_fullStr Epstein Barr virus in relation to apoptosis markers and patients' outcome in pediatric B-cell Non-Hodgkin lymphoma
title_full_unstemmed Epstein Barr virus in relation to apoptosis markers and patients' outcome in pediatric B-cell Non-Hodgkin lymphoma
title_sort Epstein Barr virus in relation to apoptosis markers and patients' outcome in pediatric B-cell Non-Hodgkin lymphoma
dc.creator.none.fl_str_mv Chabay, Paola Andrea
Lara, María Julia
Lorenzetti, Mario Alejandro
Cambra, P.
Acosta Haab, G.
Aversa, L.
de Matteo, Elena Noemí
Preciado, María Victoria
author Chabay, Paola Andrea
author_facet Chabay, Paola Andrea
Lara, María Julia
Lorenzetti, Mario Alejandro
Cambra, P.
Acosta Haab, G.
Aversa, L.
de Matteo, Elena Noemí
Preciado, María Victoria
author_role author
author2 Lara, María Julia
Lorenzetti, Mario Alejandro
Cambra, P.
Acosta Haab, G.
Aversa, L.
de Matteo, Elena Noemí
Preciado, María Victoria
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv APOPTOSIS
EPSTEIN BARR VIRUS
PEDIATRIC B-CELL NON-HODGKIN LYMPHOMA
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
topic APOPTOSIS
EPSTEIN BARR VIRUS
PEDIATRIC B-CELL NON-HODGKIN LYMPHOMA
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
description In this study, we investigated Epstein Barr virus (EBV) presence, associated to proliferation and apoptosis proteins in pediatric B-cell Non-Hodgkin lymphoma (B-NHL). EBERs, Ki67, active caspase 3, Bax and Bcl2 were analyzed on B-NHL tissue from 40 patients. Forty percent showed EBV expression, significantly higher among patients ≤10. years (P= 0.027), and associated with immunosuppression (P= 0.020), but not associated apotosis markers. However, EBV was associated with a worse event-free survival (P= 0.016), particularly under immunosuppression. Even though EBV did not seem to alter apoptotic pathways, it exhibited survival disadvantage and could be an important cofactor in B-cell lymphomagenesis in younger children.
publishDate 2011
dc.date.none.fl_str_mv 2011-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/192110
Chabay, Paola Andrea; Lara, María Julia; Lorenzetti, Mario Alejandro; Cambra, P.; Acosta Haab, G.; et al.; Epstein Barr virus in relation to apoptosis markers and patients' outcome in pediatric B-cell Non-Hodgkin lymphoma; Elsevier Ireland; Cancer Letters; 307; 2; 8-2011; 221-226
0304-3835
CONICET Digital
CONICET
url http://hdl.handle.net/11336/192110
identifier_str_mv Chabay, Paola Andrea; Lara, María Julia; Lorenzetti, Mario Alejandro; Cambra, P.; Acosta Haab, G.; et al.; Epstein Barr virus in relation to apoptosis markers and patients' outcome in pediatric B-cell Non-Hodgkin lymphoma; Elsevier Ireland; Cancer Letters; 307; 2; 8-2011; 221-226
0304-3835
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0304383511002060
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.canlet.2011.04.006
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 15.811543

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