A facile one-pot synthesis of 8-oxo-7,8-dihydro-(2′-deoxy)adenosine in water
Reaction of 2-mercaptoethanol with 8-bromo-2′-deoxyadenosine and 8-bromo-adenosine in aqueous solution and in the presence of triethylamine gave the 8-oxo-adenine derivatives in very good yields. Some mechanistic details are reported.
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2006 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/150343 |
| Acceso en línea: | http://hdl.handle.net/11336/150343 |
| Access Level: | acceso abierto |
| Palabra clave: | 8-BROMO-2′-DEOXYADENOSINE 8-OXO-7,8-DIHYDRO-2′-DEOXYADENOSINE DNA DAMAGE MERCAPTOETHANOL NUCLEOSIDES https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
| Sumario: | Reaction of 2-mercaptoethanol with 8-bromo-2′-deoxyadenosine and 8-bromo-adenosine in aqueous solution and in the presence of triethylamine gave the 8-oxo-adenine derivatives in very good yields. Some mechanistic details are reported. |
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