Increased leukotriene concentration in submandibular glands from rats with experimental periodontitis

Objective and design: In the present study, we investigated the relation between the inflammatory mediators such as nitric oxide, prostaglandins, and cysteinyl-leukotrienes with mucin release and the sympathetic system in submandibular glands from rats with experimental periodontitis. Materials or s...

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Autores: Busch, Lucila, Miozza, Valeria Alejandra, Sterin, Leonor Josefina, Borda, Enri Santiago
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2009
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/117855
Acceso en línea:http://hdl.handle.net/11336/117855
Access Level:acceso abierto
Palabra clave:CYSTEINYL-LEUKOTRIENES
MUCIN
PERIODONTAL DISEASE
SUBMANDIBULAR GLAND
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
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network_acronym_str AR
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repository_id_str
spelling Increased leukotriene concentration in submandibular glands from rats with experimental periodontitisBusch, LucilaMiozza, Valeria AlejandraSterin, Leonor JosefinaBorda, Enri SantiagoCYSTEINYL-LEUKOTRIENESMUCINPERIODONTAL DISEASESUBMANDIBULAR GLANDhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Objective and design: In the present study, we investigated the relation between the inflammatory mediators such as nitric oxide, prostaglandins, and cysteinyl-leukotrienes with mucin release and the sympathetic system in submandibular glands from rats with experimental periodontitis. Materials or subjects: Submandibular glands from rats with experimental periodontitis. Treatment: For the first experiment, rats were treated with hydrocortisone sc, 1 mg/kg for 3 days. All other experiments were carried out in isolated submandibular glands from untreated rats. Submandibular glands were treated with cysteinyl-leukotrienes, isoproterenol, NDGA, FPL 55712, L-NMMA, Nio, Nz, AMG, indomethacin, DuP 697 and atenolol. Methods: Nitric oxide synthase activity, prostaglandin and cysteinyl-leukotriene productions and mucin secretion were determined. The Newman-Keuls statistical test was applied after analysis of variance. Results: In rats with periodontitis hydrocortisone-induced a 36.6% (P < 0.05) decrease in mucin release. Only cysteinyl-leukotriene production was increased in rats with ligature (79.2%, P < 0.001). Either the inhibition of cysteinyl-leukotriene production or the block of leukotriene receptor abolished the increase in mucin secretion by 25.6% (P < 0.05) and 37% (P < 0.01), respectively, in glands from rats with ligature. On the other hand, the presence of cysteinyl-leukotrienes in the incubation medium induced mucin release from submandibular glands. Atenolol diminished by 24% (P < 0.05), the increase in cysteinyl-leukotrienes observed in rats with periodontitis. Besides, isoproterenol induced cysteinyl-leukotriene production in both groups. Conclusion: In submandibular glands from rats with periodontitis, the increment in mucin release and cysteinyl-leukotrienes production are related events and both are associated with the sympathetic system.Fil: Busch, Lucila. Universidad de Buenos Aires. Facultad de Odontología; ArgentinaFil: Miozza, Valeria Alejandra. Universidad de Buenos Aires. Facultad de Odontología; ArgentinaFil: Sterin, Leonor Josefina. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Borda, Enri Santiago. Universidad de Buenos Aires. Facultad de Odontología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaSpringer2009-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/117855Busch, Lucila; Miozza, Valeria Alejandra; Sterin, Leonor Josefina; Borda, Enri Santiago; Increased leukotriene concentration in submandibular glands from rats with experimental periodontitis; Springer; Inflammation Research; 58; 7; 4-2009; 423-4301023-3830CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s00011-009-0008-8info:eu-repo/semantics/altIdentifier/doi/10.1007/s00011-009-0008-8info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:00:22Zoai:ri.conicet.gov.ar:11336/117855instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:00:23.227CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Increased leukotriene concentration in submandibular glands from rats with experimental periodontitis
title Increased leukotriene concentration in submandibular glands from rats with experimental periodontitis
spellingShingle Increased leukotriene concentration in submandibular glands from rats with experimental periodontitis
Busch, Lucila
CYSTEINYL-LEUKOTRIENES
MUCIN
PERIODONTAL DISEASE
SUBMANDIBULAR GLAND
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
title_short Increased leukotriene concentration in submandibular glands from rats with experimental periodontitis
title_full Increased leukotriene concentration in submandibular glands from rats with experimental periodontitis
title_fullStr Increased leukotriene concentration in submandibular glands from rats with experimental periodontitis
title_full_unstemmed Increased leukotriene concentration in submandibular glands from rats with experimental periodontitis
title_sort Increased leukotriene concentration in submandibular glands from rats with experimental periodontitis
dc.creator.none.fl_str_mv Busch, Lucila
Miozza, Valeria Alejandra
Sterin, Leonor Josefina
Borda, Enri Santiago
author Busch, Lucila
author_facet Busch, Lucila
Miozza, Valeria Alejandra
Sterin, Leonor Josefina
Borda, Enri Santiago
author_role author
author2 Miozza, Valeria Alejandra
Sterin, Leonor Josefina
Borda, Enri Santiago
author2_role author
author
author
dc.subject.none.fl_str_mv CYSTEINYL-LEUKOTRIENES
MUCIN
PERIODONTAL DISEASE
SUBMANDIBULAR GLAND
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
topic CYSTEINYL-LEUKOTRIENES
MUCIN
PERIODONTAL DISEASE
SUBMANDIBULAR GLAND
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
description Objective and design: In the present study, we investigated the relation between the inflammatory mediators such as nitric oxide, prostaglandins, and cysteinyl-leukotrienes with mucin release and the sympathetic system in submandibular glands from rats with experimental periodontitis. Materials or subjects: Submandibular glands from rats with experimental periodontitis. Treatment: For the first experiment, rats were treated with hydrocortisone sc, 1 mg/kg for 3 days. All other experiments were carried out in isolated submandibular glands from untreated rats. Submandibular glands were treated with cysteinyl-leukotrienes, isoproterenol, NDGA, FPL 55712, L-NMMA, Nio, Nz, AMG, indomethacin, DuP 697 and atenolol. Methods: Nitric oxide synthase activity, prostaglandin and cysteinyl-leukotriene productions and mucin secretion were determined. The Newman-Keuls statistical test was applied after analysis of variance. Results: In rats with periodontitis hydrocortisone-induced a 36.6% (P < 0.05) decrease in mucin release. Only cysteinyl-leukotriene production was increased in rats with ligature (79.2%, P < 0.001). Either the inhibition of cysteinyl-leukotriene production or the block of leukotriene receptor abolished the increase in mucin secretion by 25.6% (P < 0.05) and 37% (P < 0.01), respectively, in glands from rats with ligature. On the other hand, the presence of cysteinyl-leukotrienes in the incubation medium induced mucin release from submandibular glands. Atenolol diminished by 24% (P < 0.05), the increase in cysteinyl-leukotrienes observed in rats with periodontitis. Besides, isoproterenol induced cysteinyl-leukotriene production in both groups. Conclusion: In submandibular glands from rats with periodontitis, the increment in mucin release and cysteinyl-leukotrienes production are related events and both are associated with the sympathetic system.
publishDate 2009
dc.date.none.fl_str_mv 2009-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/117855
Busch, Lucila; Miozza, Valeria Alejandra; Sterin, Leonor Josefina; Borda, Enri Santiago; Increased leukotriene concentration in submandibular glands from rats with experimental periodontitis; Springer; Inflammation Research; 58; 7; 4-2009; 423-430
1023-3830
CONICET Digital
CONICET
url http://hdl.handle.net/11336/117855
identifier_str_mv Busch, Lucila; Miozza, Valeria Alejandra; Sterin, Leonor Josefina; Borda, Enri Santiago; Increased leukotriene concentration in submandibular glands from rats with experimental periodontitis; Springer; Inflammation Research; 58; 7; 4-2009; 423-430
1023-3830
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s00011-009-0008-8
info:eu-repo/semantics/altIdentifier/doi/10.1007/s00011-009-0008-8
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 15,811543

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