c- Src and its role in cystic fibrosis
Cystic fibrosis (CF) is a lethal inherited disease produced by mutations in the gene encoding the CFTR chloride channel. Loss of function in the CFTR gene is associated with a not much noticed increased expression and activity of the non-receptor protein-tyrosine kinase c-Src. CF is therefore the re...
| Autores: | , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2016 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/47765 |
| Acceso en línea: | http://hdl.handle.net/11336/47765 |
| Access Level: | acceso abierto |
| Palabra clave: | C-Src Cystic-Fibrosis Cftr Intracellular-Chloride Il-1β Pp2 Il1rn https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
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c- Src and its role in cystic fibrosisMassip Copiz, María MacarenaSanta Coloma, Tomás AntonioC-SrcCystic-FibrosisCftrIntracellular-ChlorideIl-1βPp2Il1rnhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Cystic fibrosis (CF) is a lethal inherited disease produced by mutations in the gene encoding the CFTR chloride channel. Loss of function in the CFTR gene is associated with a not much noticed increased expression and activity of the non-receptor protein-tyrosine kinase c-Src. CF is therefore the result from the loss of CFTR chloride transport function and its consequences, including a chronic and excessive c-Src signaling. On the other hand, c-Src, encoded by the SRC gene, is involved in diverse signaling mechanisms that regulate key cellular functions such as cell proliferation, apoptosis, oxidative stress, inflammation, and innate immunity. These c-Src-regulated cellular functions are also affected in CF; however, studies exploring a direct role of c-Src in the regulation of these cellular functions in CF are yet scarce and often controversial. Here we describe the c-Src regulation and functions, with emphasis in those altered in CF, and describe the role of CFTR as a "signaling molecule" that negatively modulates c-Src expression and activity. It is also discussed the emerging role of intracellular Cl− and IL-1β as intermediate signaling effectors between CFTR and c-Src.Fil: Massip Copiz, María Macarena. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; ArgentinaFil: Santa Coloma, Tomás Antonio. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; ArgentinaElsevier Gmbh2016-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/47765Massip Copiz, María Macarena; Santa Coloma, Tomás Antonio; c- Src and its role in cystic fibrosis; Elsevier Gmbh; European Journal Of Cell Biology; 95; 10; 10-2016; 401-4130171-9335CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejcb.2016.08.001info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0171933516300632info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:54:30Zoai:ri.conicet.gov.ar:11336/47765instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:54:30.651CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
c- Src and its role in cystic fibrosis |
| title |
c- Src and its role in cystic fibrosis |
| spellingShingle |
c- Src and its role in cystic fibrosis Massip Copiz, María Macarena C-Src Cystic-Fibrosis Cftr Intracellular-Chloride Il-1β Pp2 Il1rn https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| title_short |
c- Src and its role in cystic fibrosis |
| title_full |
c- Src and its role in cystic fibrosis |
| title_fullStr |
c- Src and its role in cystic fibrosis |
| title_full_unstemmed |
c- Src and its role in cystic fibrosis |
| title_sort |
c- Src and its role in cystic fibrosis |
| dc.creator.none.fl_str_mv |
Massip Copiz, María Macarena Santa Coloma, Tomás Antonio |
| author |
Massip Copiz, María Macarena |
| author_facet |
Massip Copiz, María Macarena Santa Coloma, Tomás Antonio |
| author_role |
author |
| author2 |
Santa Coloma, Tomás Antonio |
| author2_role |
author |
| dc.subject.none.fl_str_mv |
C-Src Cystic-Fibrosis Cftr Intracellular-Chloride Il-1β Pp2 Il1rn https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| topic |
C-Src Cystic-Fibrosis Cftr Intracellular-Chloride Il-1β Pp2 Il1rn https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| description |
Cystic fibrosis (CF) is a lethal inherited disease produced by mutations in the gene encoding the CFTR chloride channel. Loss of function in the CFTR gene is associated with a not much noticed increased expression and activity of the non-receptor protein-tyrosine kinase c-Src. CF is therefore the result from the loss of CFTR chloride transport function and its consequences, including a chronic and excessive c-Src signaling. On the other hand, c-Src, encoded by the SRC gene, is involved in diverse signaling mechanisms that regulate key cellular functions such as cell proliferation, apoptosis, oxidative stress, inflammation, and innate immunity. These c-Src-regulated cellular functions are also affected in CF; however, studies exploring a direct role of c-Src in the regulation of these cellular functions in CF are yet scarce and often controversial. Here we describe the c-Src regulation and functions, with emphasis in those altered in CF, and describe the role of CFTR as a "signaling molecule" that negatively modulates c-Src expression and activity. It is also discussed the emerging role of intracellular Cl− and IL-1β as intermediate signaling effectors between CFTR and c-Src. |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016-10 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/47765 Massip Copiz, María Macarena; Santa Coloma, Tomás Antonio; c- Src and its role in cystic fibrosis; Elsevier Gmbh; European Journal Of Cell Biology; 95; 10; 10-2016; 401-413 0171-9335 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/47765 |
| identifier_str_mv |
Massip Copiz, María Macarena; Santa Coloma, Tomás Antonio; c- Src and its role in cystic fibrosis; Elsevier Gmbh; European Journal Of Cell Biology; 95; 10; 10-2016; 401-413 0171-9335 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejcb.2016.08.001 info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0171933516300632 |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
| eu_rights_str_mv |
openAccess |
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https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
| dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier Gmbh |
| publisher.none.fl_str_mv |
Elsevier Gmbh |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1799195502036647936 |
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15,812429 |