A mathematical model of absorbing Markov chains to understand the routes of metastasis

Metastasis is a complex and multi-step stochastic process. The study of the probabilities of generating a tumor from a primary site in another organs is the aim of this work. Based on statistics of National Institute of Cancer of Argentina (INC), a characterization of the routes of metastasis for th...

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Detalles Bibliográficos
Autores: Margarit, David Hipólito, Romanelli, Lilia Mabel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/106675
Acceso en línea:http://hdl.handle.net/11336/106675
Access Level:acceso abierto
Palabra clave:Procesos Markovianos
metastasis
cancer
https://purl.org/becyt/ford/1.2
https://purl.org/becyt/ford/1
Descripción
Sumario:Metastasis is a complex and multi-step stochastic process. The study of the probabilities of generating a tumor from a primary site in another organs is the aim of this work. Based on statistics of National Institute of Cancer of Argentina (INC), a characterization of the routes of metastasis for the principal organs is presented by using Absorbing Markov chains. The metastasis propagation from different primary sites towards secondary and tertiary sites is also shown, emphasizing the relation and analysis about absorbing states.