Multimodal mechanisms of human socially reinforced learning across neurodegenerative diseases

Social feedback can selectively enhance learning in diverse domains. Relevant neurocognitive mechanisms have been studied mainly in healthy persons, yielding correlational findings. Neurodegenerative lesion models, coupled with multimodal brain measures, can complement standard approaches by reveali...

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Autores: Legaz, Agustina, Abrevaya, Sofia, Dottori, Martín, Campo, Cecilia González, Birba, Agustina, Martorell Caro, Miguel Angel, Aguirre, María Julieta, Slachevsky, Andrea, Aranguiz, Rafael, Serrano, Cecilia Mariela, Gillan, Claire M., Leroi, Iracema, García, Adolfo Martín, Fittipaldi, Sol, Ibañez, Agustin Mariano
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/171513
Acceso en línea:http://hdl.handle.net/11336/171513
Access Level:acceso abierto
Palabra clave:ALZHEIMER'S DISEASE
BEHAVIOURAL VARIANT FRONTOTEMPORAL DEMENTIA
LEARNING
PARKINSON'S DISEASE
SOCIAL REINFORCEMENT
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
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network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Multimodal mechanisms of human socially reinforced learning across neurodegenerative diseases
title Multimodal mechanisms of human socially reinforced learning across neurodegenerative diseases
spellingShingle Multimodal mechanisms of human socially reinforced learning across neurodegenerative diseases
Legaz, Agustina
ALZHEIMER'S DISEASE
BEHAVIOURAL VARIANT FRONTOTEMPORAL DEMENTIA
LEARNING
PARKINSON'S DISEASE
SOCIAL REINFORCEMENT
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
title_short Multimodal mechanisms of human socially reinforced learning across neurodegenerative diseases
title_full Multimodal mechanisms of human socially reinforced learning across neurodegenerative diseases
title_fullStr Multimodal mechanisms of human socially reinforced learning across neurodegenerative diseases
title_full_unstemmed Multimodal mechanisms of human socially reinforced learning across neurodegenerative diseases
title_sort Multimodal mechanisms of human socially reinforced learning across neurodegenerative diseases
dc.creator.none.fl_str_mv Legaz, Agustina
Abrevaya, Sofia
Dottori, Martín
Campo, Cecilia González
Birba, Agustina
Martorell Caro, Miguel Angel
Aguirre, María Julieta
Slachevsky, Andrea
Aranguiz, Rafael
Serrano, Cecilia Mariela
Gillan, Claire M.
Leroi, Iracema
García, Adolfo Martín
Fittipaldi, Sol
Ibañez, Agustin Mariano
author Legaz, Agustina
author_facet Legaz, Agustina
Abrevaya, Sofia
Dottori, Martín
Campo, Cecilia González
Birba, Agustina
Martorell Caro, Miguel Angel
Aguirre, María Julieta
Slachevsky, Andrea
Aranguiz, Rafael
Serrano, Cecilia Mariela
Gillan, Claire M.
Leroi, Iracema
García, Adolfo Martín
Fittipaldi, Sol
Ibañez, Agustin Mariano
author_role author
author2 Abrevaya, Sofia
Dottori, Martín
Campo, Cecilia González
Birba, Agustina
Martorell Caro, Miguel Angel
Aguirre, María Julieta
Slachevsky, Andrea
Aranguiz, Rafael
Serrano, Cecilia Mariela
Gillan, Claire M.
Leroi, Iracema
García, Adolfo Martín
Fittipaldi, Sol
Ibañez, Agustin Mariano
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ALZHEIMER'S DISEASE
BEHAVIOURAL VARIANT FRONTOTEMPORAL DEMENTIA
LEARNING
PARKINSON'S DISEASE
SOCIAL REINFORCEMENT
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
topic ALZHEIMER'S DISEASE
BEHAVIOURAL VARIANT FRONTOTEMPORAL DEMENTIA
LEARNING
PARKINSON'S DISEASE
SOCIAL REINFORCEMENT
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
description Social feedback can selectively enhance learning in diverse domains. Relevant neurocognitive mechanisms have been studied mainly in healthy persons, yielding correlational findings. Neurodegenerative lesion models, coupled with multimodal brain measures, can complement standard approaches by revealing direct multidimensional correlates of the phenomenon. To this end, we assessed socially reinforced and non-socially reinforced learning in 40 healthy participants as well as persons with behavioural variant frontotemporal dementia (n = 21), Parkinson's disease (n = 31) and Alzheimer's disease (n = 20). These conditions are typified by predominant deficits in social cognition, feedback-based learning and associative learning, respectively, although all three domains may be partly compromised in the other conditions. We combined a validated behavioural task with ongoing EEG signatures of implicit learning (medial frontal negativity) and offline MRI measures (voxel-based morphometry). In healthy participants, learning was facilitated by social feedback relative to non-social feedback. In comparison with controls, this effect was specifically impaired in behavioural variant frontotemporal dementia and Parkinson's disease, while unspecific learning deficits (across social and non-social conditions) were observed in Alzheimer's disease. EEG results showed increased medial frontal negativity in healthy controls during social feedback and learning. Such a modulation was selectively disrupted in behavioural variant frontotemporal dementia. Neuroanatomical results revealed extended temporo-parietal and fronto-limbic correlates of socially reinforced learning, with specific temporo-parietal associations in behavioural variant frontotemporal dementia and predominantly fronto-limbic regions in Alzheimer's disease. In contrast, non-socially reinforced learning was consistently linked to medial temporal/hippocampal regions. No associations with cortical volume were found in Parkinson's disease. Results are consistent with core social deficits in behavioural variant frontotemporal dementia, subtle disruptions in ongoing feedback-mechanisms and social processes in Parkinson's disease and generalized learning alterations in Alzheimer's disease. This multimodal approach highlights the impact of different neurodegenerative profiles on learning and social feedback. Our findings inform a promising theoretical and clinical agenda in the fields of social learning, socially reinforced learning and neurodegeneration.
publishDate 2021
dc.date.none.fl_str_mv 2021-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/171513
Legaz, Agustina; Abrevaya, Sofia; Dottori, Martín; Campo, Cecilia González; Birba, Agustina; et al.; Multimodal mechanisms of human socially reinforced learning across neurodegenerative diseases; Oxford University Press; Brain; 145; 3; 3-2021; 1052-1068
0006-8950
CONICET Digital
CONICET
url http://hdl.handle.net/11336/171513
identifier_str_mv Legaz, Agustina; Abrevaya, Sofia; Dottori, Martín; Campo, Cecilia González; Birba, Agustina; et al.; Multimodal mechanisms of human socially reinforced learning across neurodegenerative diseases; Oxford University Press; Brain; 145; 3; 3-2021; 1052-1068
0006-8950
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awab345/6371182
info:eu-repo/semantics/altIdentifier/doi/10.1093/brain/awab345
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799194682259931136
spelling Multimodal mechanisms of human socially reinforced learning across neurodegenerative diseasesLegaz, AgustinaAbrevaya, SofiaDottori, MartínCampo, Cecilia GonzálezBirba, AgustinaMartorell Caro, Miguel AngelAguirre, María JulietaSlachevsky, AndreaAranguiz, RafaelSerrano, Cecilia MarielaGillan, Claire M.Leroi, IracemaGarcía, Adolfo MartínFittipaldi, SolIbañez, Agustin MarianoALZHEIMER'S DISEASEBEHAVIOURAL VARIANT FRONTOTEMPORAL DEMENTIALEARNINGPARKINSON'S DISEASESOCIAL REINFORCEMENThttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Social feedback can selectively enhance learning in diverse domains. Relevant neurocognitive mechanisms have been studied mainly in healthy persons, yielding correlational findings. Neurodegenerative lesion models, coupled with multimodal brain measures, can complement standard approaches by revealing direct multidimensional correlates of the phenomenon. To this end, we assessed socially reinforced and non-socially reinforced learning in 40 healthy participants as well as persons with behavioural variant frontotemporal dementia (n = 21), Parkinson's disease (n = 31) and Alzheimer's disease (n = 20). These conditions are typified by predominant deficits in social cognition, feedback-based learning and associative learning, respectively, although all three domains may be partly compromised in the other conditions. We combined a validated behavioural task with ongoing EEG signatures of implicit learning (medial frontal negativity) and offline MRI measures (voxel-based morphometry). In healthy participants, learning was facilitated by social feedback relative to non-social feedback. In comparison with controls, this effect was specifically impaired in behavioural variant frontotemporal dementia and Parkinson's disease, while unspecific learning deficits (across social and non-social conditions) were observed in Alzheimer's disease. EEG results showed increased medial frontal negativity in healthy controls during social feedback and learning. Such a modulation was selectively disrupted in behavioural variant frontotemporal dementia. Neuroanatomical results revealed extended temporo-parietal and fronto-limbic correlates of socially reinforced learning, with specific temporo-parietal associations in behavioural variant frontotemporal dementia and predominantly fronto-limbic regions in Alzheimer's disease. In contrast, non-socially reinforced learning was consistently linked to medial temporal/hippocampal regions. No associations with cortical volume were found in Parkinson's disease. Results are consistent with core social deficits in behavioural variant frontotemporal dementia, subtle disruptions in ongoing feedback-mechanisms and social processes in Parkinson's disease and generalized learning alterations in Alzheimer's disease. This multimodal approach highlights the impact of different neurodegenerative profiles on learning and social feedback. Our findings inform a promising theoretical and clinical agenda in the fields of social learning, socially reinforced learning and neurodegeneration.Fil: Legaz, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Nacional de Córdoba; ArgentinaFil: Abrevaya, Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Dottori, Martín. Universidad de San Andrés; ArgentinaFil: Campo, Cecilia González. Universidad de San Andrés; ArgentinaFil: Birba, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; ArgentinaFil: Martorell Caro, Miguel Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Aguirre, María Julieta. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; ArgentinaFil: Slachevsky, Andrea. Universidad de Chile.; ChileFil: Aranguiz, Rafael. Instituto Nacional de Geriatría; ChileFil: Serrano, Cecilia Mariela. Unidad Asistencial "Dr. César Milstein"; ArgentinaFil: Gillan, Claire M.. University of California; Estados UnidosFil: Leroi, Iracema. University of California; Estados UnidosFil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina. University of California; Estados Unidos. Trinity College; Estados Unidos. Universidad Nacional de Cuyo; Argentina. Universidad de Santiago de Chile; ChileFil: Fittipaldi, Sol. Universidad de San Andrés; ArgentinaFil: Ibañez, Agustin Mariano. Universidad de San Andrés; Argentina. University of California; Estados Unidos. Trinity College; Estados Unidos. Universidad Adolfo Ibañez; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaOxford University Press2021-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/171513Legaz, Agustina; Abrevaya, Sofia; Dottori, Martín; Campo, Cecilia González; Birba, Agustina; et al.; Multimodal mechanisms of human socially reinforced learning across neurodegenerative diseases; Oxford University Press; Brain; 145; 3; 3-2021; 1052-10680006-8950CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awab345/6371182info:eu-repo/semantics/altIdentifier/doi/10.1093/brain/awab345info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:34:09Zoai:ri.conicet.gov.ar:11336/171513instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:34:10.292CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
score 15,811543

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