Films of Poly(Hydroxybutyrate) (PHB) and Copper with Antibacterial Activity

Poly(3-hydroxybutyrate), PHB, is a hydrophobic biopolymer with good mechanical and barrier properties. However, neat PHB is a semicrystalline polymer with a relative high degree of crystallinity and poor film properties. In this work, this biopolymer was plasticized with glycerol tributyrate and fun...

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Detalles Bibliográficos
Autores: Quispe, Mayte Milenka, Villanueva, María Emilia, Copello, Guillermo Javier, Lopez, Olivia Valeria, Villar, Marcelo Armando
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/227727
Acceso en línea:http://hdl.handle.net/11336/227727
Access Level:acceso abierto
Palabra clave:POLY(HYDROXYBUTYRATE)
COPPER
SULFATE
GLYCEROLTRIBUTYRATE
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
id AR_cae41e047d005d93fa9d8cc7725951f2
oai_identifier_str oai:ri.conicet.gov.ar:11336/227727
network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Films of Poly(Hydroxybutyrate) (PHB) and Copper with Antibacterial Activity
title Films of Poly(Hydroxybutyrate) (PHB) and Copper with Antibacterial Activity
spellingShingle Films of Poly(Hydroxybutyrate) (PHB) and Copper with Antibacterial Activity
Quispe, Mayte Milenka
POLY(HYDROXYBUTYRATE)
COPPER
SULFATE
GLYCEROLTRIBUTYRATE
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
title_short Films of Poly(Hydroxybutyrate) (PHB) and Copper with Antibacterial Activity
title_full Films of Poly(Hydroxybutyrate) (PHB) and Copper with Antibacterial Activity
title_fullStr Films of Poly(Hydroxybutyrate) (PHB) and Copper with Antibacterial Activity
title_full_unstemmed Films of Poly(Hydroxybutyrate) (PHB) and Copper with Antibacterial Activity
title_sort Films of Poly(Hydroxybutyrate) (PHB) and Copper with Antibacterial Activity
dc.creator.none.fl_str_mv Quispe, Mayte Milenka
Villanueva, María Emilia
Copello, Guillermo Javier
Lopez, Olivia Valeria
Villar, Marcelo Armando
author Quispe, Mayte Milenka
author_facet Quispe, Mayte Milenka
Villanueva, María Emilia
Copello, Guillermo Javier
Lopez, Olivia Valeria
Villar, Marcelo Armando
author_role author
author2 Villanueva, María Emilia
Copello, Guillermo Javier
Lopez, Olivia Valeria
Villar, Marcelo Armando
author2_role author
author
author
author
dc.subject.none.fl_str_mv POLY(HYDROXYBUTYRATE)
COPPER
SULFATE
GLYCEROLTRIBUTYRATE
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
topic POLY(HYDROXYBUTYRATE)
COPPER
SULFATE
GLYCEROLTRIBUTYRATE
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
description Poly(3-hydroxybutyrate), PHB, is a hydrophobic biopolymer with good mechanical and barrier properties. However, neat PHB is a semicrystalline polymer with a relative high degree of crystallinity and poor film properties. In this work, this biopolymer was plasticized with glycerol tributyrate and functionalized with copper (II) sulfate, allowing us to obtain biodegradable antimicrobial flexible films. Films with the minimum inhibitory concentration (MIC) of copper (II) sulfate presented a higher roughness than neat PHB films. The presence of plasticizer significantly improved the copper sulfate diffusion process, which was evidenced by a greater inhibition halo for plasticized materials compared to unplasticized ones, at the same salt concentration. Plasticized PHB with 2.5% copper (II) sulfate inhibited both Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomona aeruginosa) bacteria, as determined by the bacterial inhibition halo. In addition, neat PHB films and PHB containing copper (II) sulfate did not show in vitro cytotoxicity in the L-929 cell line. Thus, plasticized PHB functionalized with copper (II) sulfate can be used as biodegradable antimicrobial flexible films for different applications.
publishDate 2023
dc.date.none.fl_str_mv 2023-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/227727
Quispe, Mayte Milenka; Villanueva, María Emilia; Copello, Guillermo Javier; Lopez, Olivia Valeria; Villar, Marcelo Armando; Films of Poly(Hydroxybutyrate) (PHB) and Copper with Antibacterial Activity; Multidisciplinary Digital Publishing Institute; Polymers; 15; 13; 7-2023; 1-12
2073-4360
CONICET Digital
CONICET
url http://hdl.handle.net/11336/227727
identifier_str_mv Quispe, Mayte Milenka; Villanueva, María Emilia; Copello, Guillermo Javier; Lopez, Olivia Valeria; Villar, Marcelo Armando; Films of Poly(Hydroxybutyrate) (PHB) and Copper with Antibacterial Activity; Multidisciplinary Digital Publishing Institute; Polymers; 15; 13; 7-2023; 1-12
2073-4360
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2073-4360/15/13/2907
info:eu-repo/semantics/altIdentifier/doi/10.3390/polym15132907
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799195137809580032
spelling Films of Poly(Hydroxybutyrate) (PHB) and Copper with Antibacterial ActivityQuispe, Mayte MilenkaVillanueva, María EmiliaCopello, Guillermo JavierLopez, Olivia ValeriaVillar, Marcelo ArmandoPOLY(HYDROXYBUTYRATE)COPPERSULFATEGLYCEROLTRIBUTYRATEhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Poly(3-hydroxybutyrate), PHB, is a hydrophobic biopolymer with good mechanical and barrier properties. However, neat PHB is a semicrystalline polymer with a relative high degree of crystallinity and poor film properties. In this work, this biopolymer was plasticized with glycerol tributyrate and functionalized with copper (II) sulfate, allowing us to obtain biodegradable antimicrobial flexible films. Films with the minimum inhibitory concentration (MIC) of copper (II) sulfate presented a higher roughness than neat PHB films. The presence of plasticizer significantly improved the copper sulfate diffusion process, which was evidenced by a greater inhibition halo for plasticized materials compared to unplasticized ones, at the same salt concentration. Plasticized PHB with 2.5% copper (II) sulfate inhibited both Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomona aeruginosa) bacteria, as determined by the bacterial inhibition halo. In addition, neat PHB films and PHB containing copper (II) sulfate did not show in vitro cytotoxicity in the L-929 cell line. Thus, plasticized PHB functionalized with copper (II) sulfate can be used as biodegradable antimicrobial flexible films for different applications.Fil: Quispe, Mayte Milenka. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaFil: Villanueva, María Emilia. Universidad Nacional de Luján. Departamento de Ciencias Básicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Copello, Guillermo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Lopez, Olivia Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaFil: Villar, Marcelo Armando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química; ArgentinaMultidisciplinary Digital Publishing Institute2023-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/227727Quispe, Mayte Milenka; Villanueva, María Emilia; Copello, Guillermo Javier; Lopez, Olivia Valeria; Villar, Marcelo Armando; Films of Poly(Hydroxybutyrate) (PHB) and Copper with Antibacterial Activity; Multidisciplinary Digital Publishing Institute; Polymers; 15; 13; 7-2023; 1-122073-4360CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2073-4360/15/13/2907info:eu-repo/semantics/altIdentifier/doi/10.3390/polym15132907info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:44:24Zoai:ri.conicet.gov.ar:11336/227727instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:44:24.96CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
score 15.812429

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