Synthesis and Properties of Dendronized Chitosan
Chitosan films and microspheres were prepared and their surfaces were functionalized with first generation dendritic molecules. The films were modified by Weisocyanate dendron, while Behera?s and bis Behera?s amine dendrons were used to modify the microspheres. Prior to dendronization films were pre...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2010 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/14731 |
| Acceso en línea: | http://hdl.handle.net/11336/14731 |
| Access Level: | acceso abierto |
| Palabra clave: | Biomaterials Dendronization Dendronized Chitosan Functional Polymers https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
| Sumario: | Chitosan films and microspheres were prepared and their surfaces were functionalized with first generation dendritic molecules. The films were modified by Weisocyanate dendron, while Behera?s and bis Behera?s amine dendrons were used to modify the microspheres. Prior to dendronization films were prepared by blending chitosan with 18% of polyvinyl pyrrolidone (PVP), and casting the resulting mixture. The degree of dendronization reached was 28%. The microspheres were prepared by coacervation/precipitation, after which the surfaces were activated with either epychlorohydrine (ECH) or 1,4-butanediol diglycidyl ether (BDGE). The oxirane groups were utilized to form covalent bonds between chitosan and dendrons. The degree of dendronization yielded with Behera?s amine was 60% for both activating agents. When bis Behera?s amine was used, the dendronization reached values of 15 and 21% when ECH or BDGE were used, respectively. The dendronized products were characterized through spectroscopic and microscopic studies and by determination of swelling indexes. Only one of the surfaces was dendronized in every film, which therefore presented a hydrophobic and a hydrophilic surface. Since these films maintain the properties of chitosan, they offer interesting potential as dressings for exuding wounds. The different surfaces make the microspheres potentially applicable as carriers for delivery and controlled release of drugs. |
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