Acute ghrelin administration reverses depressive-like behavior induced by bilateral olfactory bulbectomy in mice

This study aims to examine the antidepressant-like action of Ghrelin (Ghr), a hormone synthesized predominantly by gastrointestinal endocrine cells and released during periods of negative energy balance, in two behavioral models: tail suspension test (TST), a predictive model of antidepressant activ...

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Autores: Carlini, Valeria Paola, Machado, Daniele Guilhermano, Buteler, Florencia, Ghersi, Marisa Soledad, Ponzio, Marina Flavia, Martini, Ana Carolina, Schiöth, Helgi Birgir, De Cuneo, Marta Fiol, Rodrigues, Ana Lúcia S., De Barioglio, Susana R.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:Argentina
Recursos:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/133787
Acesso em linha:http://hdl.handle.net/11336/133787
Access Level:acceso abierto
Palavra-chave:ANTIDEPRESSANT
GHRELIN
HYPERACTIVITY
OLFACTORY BULBECTOMY
TAIL SUSPENSION TEST
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
id AR_c70cb99e657debd58cc407bde3aec3e1
oai_identifier_str oai:ri.conicet.gov.ar:11336/133787
network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Acute ghrelin administration reverses depressive-like behavior induced by bilateral olfactory bulbectomy in mice
title Acute ghrelin administration reverses depressive-like behavior induced by bilateral olfactory bulbectomy in mice
spellingShingle Acute ghrelin administration reverses depressive-like behavior induced by bilateral olfactory bulbectomy in mice
Carlini, Valeria Paola
ANTIDEPRESSANT
GHRELIN
HYPERACTIVITY
OLFACTORY BULBECTOMY
TAIL SUSPENSION TEST
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
title_short Acute ghrelin administration reverses depressive-like behavior induced by bilateral olfactory bulbectomy in mice
title_full Acute ghrelin administration reverses depressive-like behavior induced by bilateral olfactory bulbectomy in mice
title_fullStr Acute ghrelin administration reverses depressive-like behavior induced by bilateral olfactory bulbectomy in mice
title_full_unstemmed Acute ghrelin administration reverses depressive-like behavior induced by bilateral olfactory bulbectomy in mice
title_sort Acute ghrelin administration reverses depressive-like behavior induced by bilateral olfactory bulbectomy in mice
dc.creator.none.fl_str_mv Carlini, Valeria Paola
Machado, Daniele Guilhermano
Buteler, Florencia
Ghersi, Marisa Soledad
Ponzio, Marina Flavia
Martini, Ana Carolina
Schiöth, Helgi Birgir
De Cuneo, Marta Fiol
Rodrigues, Ana Lúcia S.
De Barioglio, Susana R.
author Carlini, Valeria Paola
author_facet Carlini, Valeria Paola
Machado, Daniele Guilhermano
Buteler, Florencia
Ghersi, Marisa Soledad
Ponzio, Marina Flavia
Martini, Ana Carolina
Schiöth, Helgi Birgir
De Cuneo, Marta Fiol
Rodrigues, Ana Lúcia S.
De Barioglio, Susana R.
author_role author
author2 Machado, Daniele Guilhermano
Buteler, Florencia
Ghersi, Marisa Soledad
Ponzio, Marina Flavia
Martini, Ana Carolina
Schiöth, Helgi Birgir
De Cuneo, Marta Fiol
Rodrigues, Ana Lúcia S.
De Barioglio, Susana R.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ANTIDEPRESSANT
GHRELIN
HYPERACTIVITY
OLFACTORY BULBECTOMY
TAIL SUSPENSION TEST
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
topic ANTIDEPRESSANT
GHRELIN
HYPERACTIVITY
OLFACTORY BULBECTOMY
TAIL SUSPENSION TEST
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
description This study aims to examine the antidepressant-like action of Ghrelin (Ghr), a hormone synthesized predominantly by gastrointestinal endocrine cells and released during periods of negative energy balance, in two behavioral models: tail suspension test (TST), a predictive model of antidepressant activity, and the olfactory bulbectomy (OB), an established animal model of depression. The reduction in the immobility time in the TST was the parameter used to assess antidepressant-like effect of Ghr. The depressive-like behavior in olfactory bulbectomized mice was inferred through the increase in the immobility time in the TST and the hyperlocomotor activity in the open-field test. Ghr produced antidepressant-like effect in TST (0.3 nmol/μl, i.c.v.), and reversed OB-induced depressive-like behavior. In conclusion, these results provide clear evidence that an acute administration of ghrelin produce antidepressant-like effect in the TST and OB. © 2012 Elsevier Inc. All rights reserved.
publishDate 2012
dc.date.none.fl_str_mv 2012-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/133787
Carlini, Valeria Paola; Machado, Daniele Guilhermano; Buteler, Florencia; Ghersi, Marisa Soledad; Ponzio, Marina Flavia; et al.; Acute ghrelin administration reverses depressive-like behavior induced by bilateral olfactory bulbectomy in mice; Elsevier Science Inc; Peptides; 35; 2; 6-2012; 160-165
0196-9781
CONICET Digital
CONICET
url http://hdl.handle.net/11336/133787
identifier_str_mv Carlini, Valeria Paola; Machado, Daniele Guilhermano; Buteler, Florencia; Ghersi, Marisa Soledad; Ponzio, Marina Flavia; et al.; Acute ghrelin administration reverses depressive-like behavior induced by bilateral olfactory bulbectomy in mice; Elsevier Science Inc; Peptides; 35; 2; 6-2012; 160-165
0196-9781
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.peptides.2012.03.031
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0196978112001660
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc
publisher.none.fl_str_mv Elsevier Science Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799195996644704256
spelling Acute ghrelin administration reverses depressive-like behavior induced by bilateral olfactory bulbectomy in miceCarlini, Valeria PaolaMachado, Daniele GuilhermanoButeler, FlorenciaGhersi, Marisa SoledadPonzio, Marina FlaviaMartini, Ana CarolinaSchiöth, Helgi BirgirDe Cuneo, Marta FiolRodrigues, Ana Lúcia S.De Barioglio, Susana R.ANTIDEPRESSANTGHRELINHYPERACTIVITYOLFACTORY BULBECTOMYTAIL SUSPENSION TESThttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3This study aims to examine the antidepressant-like action of Ghrelin (Ghr), a hormone synthesized predominantly by gastrointestinal endocrine cells and released during periods of negative energy balance, in two behavioral models: tail suspension test (TST), a predictive model of antidepressant activity, and the olfactory bulbectomy (OB), an established animal model of depression. The reduction in the immobility time in the TST was the parameter used to assess antidepressant-like effect of Ghr. The depressive-like behavior in olfactory bulbectomized mice was inferred through the increase in the immobility time in the TST and the hyperlocomotor activity in the open-field test. Ghr produced antidepressant-like effect in TST (0.3 nmol/μl, i.c.v.), and reversed OB-induced depressive-like behavior. In conclusion, these results provide clear evidence that an acute administration of ghrelin produce antidepressant-like effect in the TST and OB. © 2012 Elsevier Inc. All rights reserved.Fil: Carlini, Valeria Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Machado, Daniele Guilhermano. Universidade Federal de Santa Catarina; BrasilFil: Buteler, Florencia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; ArgentinaFil: Ghersi, Marisa Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; ArgentinaFil: Ponzio, Marina Flavia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Martini, Ana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Schiöth, Helgi Birgir. Uppsala Universitet; SueciaFil: De Cuneo, Marta Fiol. Universidad Nacional de Córdoba; Facultad de Medicina.; ArgentinaFil: Rodrigues, Ana Lúcia S.. Universidade Federal Da Santa Catarina. Centro de Ciencias Biológicas; BrasilFil: De Barioglio, Susana R.. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; ArgentinaElsevier Science Inc2012-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/133787Carlini, Valeria Paola; Machado, Daniele Guilhermano; Buteler, Florencia; Ghersi, Marisa Soledad; Ponzio, Marina Flavia; et al.; Acute ghrelin administration reverses depressive-like behavior induced by bilateral olfactory bulbectomy in mice; Elsevier Science Inc; Peptides; 35; 2; 6-2012; 160-1650196-9781CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.peptides.2012.03.031info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0196978112001660info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:11:05Zoai:ri.conicet.gov.ar:11336/133787instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:11:05.838CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
score 15,811543

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