Retinoblastoma seeds: Impact on American Joint Committee on Cancer clinical staging

Tomar, Ankit Singh; Finger, Paul T.; Gallie, Brenda; Kivelä, Tero; Mallipatna, Ashwin; Zhang, Chengyue; Zhao, Junyang; Wilson, Matthew; Brennan, Rachel; Burges, Michala; Kim, Jonathan; Berry, Jesse L.; Jubran, Rima; Khetan, Vikas; Ganeshan, Suganeswari; Yarovoy, Andrey; Yarovaya, Vera; Kotova, Elena; Volodin, Denis; Yousef, Yacoub; Nummi, Kalle; Ushakova, Tatiana L.; Yugay, Olga V.; Polyakov, Vladimir G; Ramirez Ortiz, Marco Antonio; Esparza Aguiar, Elizabeth; Chantada, Guillermo Luis; Schaiquevich, Paula Susana; Fandiño, Adriana Cristina; Yam, Jason C.

Retinoblastoma seeds: Impact on American Joint Committee on Cancer clinical staging

Aim To investigate whether the American Joint Committee on Cancer (AJCC) clinical category cT2b needs to be subclassified by the type and distribution of retinoblastoma (RB) seeding. Methods Multicentre, international registry-based data were collected from RB centres enrolled between January 2001 a...

Descripción completa

Detalles Bibliográficos
Autores:	Tomar, Ankit Singh, Finger, Paul T., Gallie, Brenda, Kivelä, Tero, Mallipatna, Ashwin, Zhang, Chengyue, Zhao, Junyang, Wilson, Matthew, Brennan, Rachel, Burges, Michala, Kim, Jonathan, Berry, Jesse L., Jubran, Rima, Khetan, Vikas, Ganeshan, Suganeswari, Yarovoy, Andrey, Yarovaya, Vera, Kotova, Elena, Volodin, Denis, Yousef, Yacoub, Nummi, Kalle, Ushakova, Tatiana L., Yugay, Olga V., Polyakov, Vladimir G, Ramirez Ortiz, Marco Antonio, Esparza Aguiar, Elizabeth, Chantada, Guillermo Luis, Schaiquevich, Paula Susana, Fandiño, Adriana Cristina, Yam, Jason C.
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2021
País:	Argentina
Institución:	Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:	CONICET Digital (CONICET)
Idioma:	inglés
OAI Identifier:	oai:ri.conicet.gov.ar:11336/166903
Acceso en línea:	http://hdl.handle.net/11336/166903
Access Level:	acceso abierto
Palabra clave:	retinoblastoma vitreous seeds treatment AJCC https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3

id	AR_c5e7ec72f72425d2bef7d78cdea51e7e
oai_identifier_str	oai:ri.conicet.gov.ar:11336/166903
network_acronym_str	AR
network_name_str	Argentina
repository_id_str
dc.title.none.fl_str_mv	Retinoblastoma seeds: Impact on American Joint Committee on Cancer clinical staging
title	Retinoblastoma seeds: Impact on American Joint Committee on Cancer clinical staging
spellingShingle	Retinoblastoma seeds: Impact on American Joint Committee on Cancer clinical staging Tomar, Ankit Singh retinoblastoma vitreous seeds treatment AJCC https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3
title_short	Retinoblastoma seeds: Impact on American Joint Committee on Cancer clinical staging
title_full	Retinoblastoma seeds: Impact on American Joint Committee on Cancer clinical staging
title_fullStr	Retinoblastoma seeds: Impact on American Joint Committee on Cancer clinical staging
title_full_unstemmed	Retinoblastoma seeds: Impact on American Joint Committee on Cancer clinical staging
title_sort	Retinoblastoma seeds: Impact on American Joint Committee on Cancer clinical staging
dc.creator.none.fl_str_mv	Tomar, Ankit Singh Finger, Paul T. Gallie, Brenda Kivelä, Tero Mallipatna, Ashwin Zhang, Chengyue Zhao, Junyang Wilson, Matthew Brennan, Rachel Burges, Michala Kim, Jonathan Berry, Jesse L. Jubran, Rima Khetan, Vikas Ganeshan, Suganeswari Yarovoy, Andrey Yarovaya, Vera Kotova, Elena Volodin, Denis Yousef, Yacoub Nummi, Kalle Ushakova, Tatiana L. Yugay, Olga V. Polyakov, Vladimir G Ramirez Ortiz, Marco Antonio Esparza Aguiar, Elizabeth Chantada, Guillermo Luis Schaiquevich, Paula Susana Fandiño, Adriana Cristina Yam, Jason C.
author	Tomar, Ankit Singh
author_facet	Tomar, Ankit Singh Finger, Paul T. Gallie, Brenda Kivelä, Tero Mallipatna, Ashwin Zhang, Chengyue Zhao, Junyang Wilson, Matthew Brennan, Rachel Burges, Michala Kim, Jonathan Berry, Jesse L. Jubran, Rima Khetan, Vikas Ganeshan, Suganeswari Yarovoy, Andrey Yarovaya, Vera Kotova, Elena Volodin, Denis Yousef, Yacoub Nummi, Kalle Ushakova, Tatiana L. Yugay, Olga V. Polyakov, Vladimir G Ramirez Ortiz, Marco Antonio Esparza Aguiar, Elizabeth Chantada, Guillermo Luis Schaiquevich, Paula Susana Fandiño, Adriana Cristina Yam, Jason C.
author_role	author
author2	Finger, Paul T. Gallie, Brenda Kivelä, Tero Mallipatna, Ashwin Zhang, Chengyue Zhao, Junyang Wilson, Matthew Brennan, Rachel Burges, Michala Kim, Jonathan Berry, Jesse L. Jubran, Rima Khetan, Vikas Ganeshan, Suganeswari Yarovoy, Andrey Yarovaya, Vera Kotova, Elena Volodin, Denis Yousef, Yacoub Nummi, Kalle Ushakova, Tatiana L. Yugay, Olga V. Polyakov, Vladimir G Ramirez Ortiz, Marco Antonio Esparza Aguiar, Elizabeth Chantada, Guillermo Luis Schaiquevich, Paula Susana Fandiño, Adriana Cristina Yam, Jason C.
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	retinoblastoma vitreous seeds treatment AJCC https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3
topic	retinoblastoma vitreous seeds treatment AJCC https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3
description	Aim To investigate whether the American Joint Committee on Cancer (AJCC) clinical category cT2b needs to be subclassified by the type and distribution of retinoblastoma (RB) seeding. Methods Multicentre, international registry-based data were collected from RB centres enrolled between January 2001 and December 2013. 1054 RB eyes with vitreous or subretinal seeds from 18 ophthalmic oncology centres, in 13 countries within six continents were analysed. Local treatment failure was defined as the use of secondary enucleation or external beam radiation therapy (EBRT) and was estimated with the Kaplan-Meier method. Results Clinical category cT2b included 1054 eyes. Median age at presentation was 16.0 months. Of these, 428 (40.6%) eyes were salvaged, and 430 (40.8%) were treated with primary and 196 (18.6%) with secondary enucleation. Of the 592 eyes that had complete data for globe salvage analysis, the distribution of seeds was focal in 143 (24.2%) and diffuse in 449 (75.8%). The 5-year Kaplan-Meier cumulative globe-salvage (without EBRT) was 78% and 49% for eyes with focal and diffuse RB seeding, respectively. Cox proportional hazards regression analysis confirmed a higher local treatment failure risk with diffuse seeds as compared with focal seeds (hazard rate: 2.8; p<0.001). There was insufficient evidence to prove or disprove an association between vitreous seed type and local treatment failure risk(p=0.06). Conclusion This international, multicentre, registry-based analysis of RB eyes affirmed that eyes with diffuse intraocular distribution of RB seeds at diagnosis had a higher risk of local treatment failure when compared with focal seeds. Subclassification of AJCC RB category cT2b into focal vs diffuse seeds will improve prognostication for eye salvage.
publishDate	2021
dc.date.none.fl_str_mv	2021-08
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/11336/166903 Tomar, Ankit Singh; Finger, Paul T.; Gallie, Brenda; Kivelä, Tero; Mallipatna, Ashwin; et al.; Retinoblastoma seeds: Impact on American Joint Committee on Cancer clinical staging; B M J Publishing Group; British Journal Of Ophthalmology; 2021; 8-2021; 1-6 0007-1161 CONICET Digital CONICET
url	http://hdl.handle.net/11336/166903
identifier_str_mv	Tomar, Ankit Singh; Finger, Paul T.; Gallie, Brenda; Kivelä, Tero; Mallipatna, Ashwin; et al.; Retinoblastoma seeds: Impact on American Joint Committee on Cancer clinical staging; B M J Publishing Group; British Journal Of Ophthalmology; 2021; 8-2021; 1-6 0007-1161 CONICET Digital CONICET
dc.language.none.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	info:eu-repo/semantics/altIdentifier/doi/10.1136/bjophthalmol-2021-318892 info:eu-repo/semantics/altIdentifier/url/https://bjo.bmj.com/content/early/2021/08/01/bjophthalmol-2021-318892
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv	openAccess
rights_invalid_str_mv	https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv	application/pdf application/pdf
dc.publisher.none.fl_str_mv	B M J Publishing Group
publisher.none.fl_str_mv	B M J Publishing Group
dc.source.none.fl_str_mv	reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str	Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str	CONICET Digital (CONICET)
collection	CONICET Digital (CONICET)
repository.name.fl_str_mv	CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv	dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_	1799195851919196160
spelling	Retinoblastoma seeds: Impact on American Joint Committee on Cancer clinical stagingTomar, Ankit SinghFinger, Paul T.Gallie, BrendaKivelä, TeroMallipatna, AshwinZhang, ChengyueZhao, JunyangWilson, MatthewBrennan, RachelBurges, MichalaKim, JonathanBerry, Jesse L.Jubran, RimaKhetan, VikasGaneshan, SuganeswariYarovoy, AndreyYarovaya, VeraKotova, ElenaVolodin, DenisYousef, YacoubNummi, KalleUshakova, Tatiana L.Yugay, Olga V.Polyakov, Vladimir GRamirez Ortiz, Marco AntonioEsparza Aguiar, ElizabethChantada, Guillermo LuisSchaiquevich, Paula SusanaFandiño, Adriana CristinaYam, Jason C.retinoblastomavitreous seedstreatmentAJCChttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Aim To investigate whether the American Joint Committee on Cancer (AJCC) clinical category cT2b needs to be subclassified by the type and distribution of retinoblastoma (RB) seeding. Methods Multicentre, international registry-based data were collected from RB centres enrolled between January 2001 and December 2013. 1054 RB eyes with vitreous or subretinal seeds from 18 ophthalmic oncology centres, in 13 countries within six continents were analysed. Local treatment failure was defined as the use of secondary enucleation or external beam radiation therapy (EBRT) and was estimated with the Kaplan-Meier method. Results Clinical category cT2b included 1054 eyes. Median age at presentation was 16.0 months. Of these, 428 (40.6%) eyes were salvaged, and 430 (40.8%) were treated with primary and 196 (18.6%) with secondary enucleation. Of the 592 eyes that had complete data for globe salvage analysis, the distribution of seeds was focal in 143 (24.2%) and diffuse in 449 (75.8%). The 5-year Kaplan-Meier cumulative globe-salvage (without EBRT) was 78% and 49% for eyes with focal and diffuse RB seeding, respectively. Cox proportional hazards regression analysis confirmed a higher local treatment failure risk with diffuse seeds as compared with focal seeds (hazard rate: 2.8; p<0.001). There was insufficient evidence to prove or disprove an association between vitreous seed type and local treatment failure risk(p=0.06). Conclusion This international, multicentre, registry-based analysis of RB eyes affirmed that eyes with diffuse intraocular distribution of RB seeds at diagnosis had a higher risk of local treatment failure when compared with focal seeds. Subclassification of AJCC RB category cT2b into focal vs diffuse seeds will improve prognostication for eye salvage.Fil: Tomar, Ankit Singh. New York Eye Cancer Center; Estados UnidosFil: Finger, Paul T.. New York Eye Cancer Center; Estados UnidosFil: Gallie, Brenda. University Of Toronto. Hospital For Sick Children; CanadáFil: Kivelä, Tero. University of Helsinki; Finlandia. Helsinki University Hospital; FinlandiaFil: Mallipatna, Ashwin. University Of Toronto. Hospital For Sick Children; Canadá. Narayana Nethralaya; IndiaFil: Zhang, Chengyue. Beijing Children's Hospital; ChinaFil: Zhao, Junyang. Beijing Children's Hospital; ChinaFil: Wilson, Matthew. University of Tennessee; Estados UnidosFil: Brennan, Rachel. St Jude Children's Research Hospital; Estados UnidosFil: Burges, Michala. University of Tennessee; Estados UnidosFil: Kim, Jonathan. Keck Medical School of the University of Southern California; Estados UnidosFil: Berry, Jesse L.. Children's Hospital Los Angeles; Estados UnidosFil: Jubran, Rima. Childrens Hospital Society of Los Angeles; Estados UnidosFil: Khetan, Vikas. Vitreo Retinal Services; IndiaFil: Ganeshan, Suganeswari. Vitreo Retinal Services; IndiaFil: Yarovoy, Andrey. Fyodorov Eye Microsurgery Federal State Institution; RusiaFil: Yarovaya, Vera. Fyodorov Eye Microsurgery Federal State Institution; RusiaFil: Kotova, Elena. Fyodorov Eye Microsurgery Federal State Institution; RusiaFil: Volodin, Denis. Fyodorov Eye Microsurgery Federal State Institution; RusiaFil: Yousef, Yacoub. King Hussein Cancer Center; JordaniaFil: Nummi, Kalle. University of Helsinki; Finlandia. Helsinki University Hospital; FinlandiaFil: Ushakova, Tatiana L.. N.N. Blokhin Russian Cancer Research Center; Rusia. Russian Academy of Postgraduate Medical Education; RusiaFil: Yugay, Olga V.. N.N. Blokhin Russian Cancer Research Center; RusiaFil: Polyakov, Vladimir G. N.N. Blokhin Russian Cancer Research Center; Rusia. Russian Academy of Sciences; RusiaFil: Ramirez Ortiz, Marco Antonio. Hospital Infantil de Mexico Federico Gomez; MéxicoFil: Esparza Aguiar, Elizabeth. Hospital Infantil de Mexico Federico Gomez; MéxicoFil: Chantada, Guillermo Luis. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Schaiquevich, Paula Susana. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Fandiño, Adriana Cristina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Yam, Jason C.. The Chinese University of Hong Kong Faculty of Medicine; Hong KongB M J Publishing Group2021-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/166903Tomar, Ankit Singh; Finger, Paul T.; Gallie, Brenda; Kivelä, Tero; Mallipatna, Ashwin; et al.; Retinoblastoma seeds: Impact on American Joint Committee on Cancer clinical staging; B M J Publishing Group; British Journal Of Ophthalmology; 2021; 8-2021; 1-60007-1161CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1136/bjophthalmol-2021-318892info:eu-repo/semantics/altIdentifier/url/https://bjo.bmj.com/content/early/2021/08/01/bjophthalmol-2021-318892info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:05:59Zoai:ri.conicet.gov.ar:11336/166903instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:06:00.271CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
score	15,811543

Retinoblastoma seeds: Impact on American Joint Committee on Cancer clinical staging

Similares en LA Referencia