Mitochondrial nitric oxide in the signaling of cell integrated responses

Mitochondria are the specialized organelles for energy metabolism, but, as a typical example of system biology, they also activate a multiplicity of pathways that modulate cell proliferation and mitochondrial biogenesis or oppositely promote cell arrest and programmed cell death by a limited number...

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Detalhes bibliográficos
Autores: Carreras, Maria Cecilia, Poderoso, Juan José
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2007
País:Argentina
Recursos:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/120503
Acesso em linha:http://hdl.handle.net/11336/120503
Access Level:acceso abierto
Palavra-chave:HYDROGEN PEROXIDE
MITOCHONDRIAL NITRIC OXIDE SYNTHASE
MITOGEN-ACTIVATED PROTEIN KINASE
PEROXYNITRITE
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
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repository_id_str
spelling Mitochondrial nitric oxide in the signaling of cell integrated responsesCarreras, Maria CeciliaPoderoso, Juan JoséHYDROGEN PEROXIDEMITOCHONDRIAL NITRIC OXIDE SYNTHASEMITOGEN-ACTIVATED PROTEIN KINASEPEROXYNITRITEhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Mitochondria are the specialized organelles for energy metabolism, but, as a typical example of system biology, they also activate a multiplicity of pathways that modulate cell proliferation and mitochondrial biogenesis or oppositely promote cell arrest and programmed cell death by a limited number of oxidative or nitrosative reactions. These reactions are influenced by matrix nitric oxide (NO) steady-state concentration, either from local production or by gas diffusion to mitochondria from the canonical sources. Likewise, in a range of ∼30-200 nM, NO turns mitochondrial O2 utilization down by binding to cytochrome oxidase and elicits a burst of superoxide anion and hydrogen peroxide that diffuses outside mitochondria. Depending on NO levels and antioxidant defenses, more or less H2O2 accumulates in cytosol and nucleus, and the resulting redox grading contributes to dual activation of proliferating and proapoptotic cascades, like ERK1/2 or p38 MAPK. Moreover, these sequential activating pathways participate in rat liver and brain development and in thyroid modulation of mitochondrial metabolism and contribute to hypothyroid phenotype through complex I nitration. On the contrary, lack of NO disrupts pathways like S-nitrosylation or H 2O2 production and likewise is a gateway to disease in amyotrophic lateral sclerosis with superoxide dismutase 1 mutations or to cancer proliferation.Fil: Carreras, Maria Cecilia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; ArgentinaFil: Poderoso, Juan José. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; ArgentinaAmerican Physiological Society2007-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/120503Carreras, Maria Cecilia; Poderoso, Juan José; Mitochondrial nitric oxide in the signaling of cell integrated responses; American Physiological Society; American Journal of Physiology-cell Physiology; 292; 5; 1-5-2007; C1569-C15800363-6143CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1152/ajpcell.00248.2006info:eu-repo/semantics/altIdentifier/url/https://journals.physiology.org/doi/full/10.1152/ajpcell.00248.2006info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:46:27Zoai:ri.conicet.gov.ar:11336/120503instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:46:27.573CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Mitochondrial nitric oxide in the signaling of cell integrated responses
title Mitochondrial nitric oxide in the signaling of cell integrated responses
spellingShingle Mitochondrial nitric oxide in the signaling of cell integrated responses
Carreras, Maria Cecilia
HYDROGEN PEROXIDE
MITOCHONDRIAL NITRIC OXIDE SYNTHASE
MITOGEN-ACTIVATED PROTEIN KINASE
PEROXYNITRITE
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
title_short Mitochondrial nitric oxide in the signaling of cell integrated responses
title_full Mitochondrial nitric oxide in the signaling of cell integrated responses
title_fullStr Mitochondrial nitric oxide in the signaling of cell integrated responses
title_full_unstemmed Mitochondrial nitric oxide in the signaling of cell integrated responses
title_sort Mitochondrial nitric oxide in the signaling of cell integrated responses
dc.creator.none.fl_str_mv Carreras, Maria Cecilia
Poderoso, Juan José
author Carreras, Maria Cecilia
author_facet Carreras, Maria Cecilia
Poderoso, Juan José
author_role author
author2 Poderoso, Juan José
author2_role author
dc.subject.none.fl_str_mv HYDROGEN PEROXIDE
MITOCHONDRIAL NITRIC OXIDE SYNTHASE
MITOGEN-ACTIVATED PROTEIN KINASE
PEROXYNITRITE
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
topic HYDROGEN PEROXIDE
MITOCHONDRIAL NITRIC OXIDE SYNTHASE
MITOGEN-ACTIVATED PROTEIN KINASE
PEROXYNITRITE
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
description Mitochondria are the specialized organelles for energy metabolism, but, as a typical example of system biology, they also activate a multiplicity of pathways that modulate cell proliferation and mitochondrial biogenesis or oppositely promote cell arrest and programmed cell death by a limited number of oxidative or nitrosative reactions. These reactions are influenced by matrix nitric oxide (NO) steady-state concentration, either from local production or by gas diffusion to mitochondria from the canonical sources. Likewise, in a range of ∼30-200 nM, NO turns mitochondrial O2 utilization down by binding to cytochrome oxidase and elicits a burst of superoxide anion and hydrogen peroxide that diffuses outside mitochondria. Depending on NO levels and antioxidant defenses, more or less H2O2 accumulates in cytosol and nucleus, and the resulting redox grading contributes to dual activation of proliferating and proapoptotic cascades, like ERK1/2 or p38 MAPK. Moreover, these sequential activating pathways participate in rat liver and brain development and in thyroid modulation of mitochondrial metabolism and contribute to hypothyroid phenotype through complex I nitration. On the contrary, lack of NO disrupts pathways like S-nitrosylation or H 2O2 production and likewise is a gateway to disease in amyotrophic lateral sclerosis with superoxide dismutase 1 mutations or to cancer proliferation.
publishDate 2007
dc.date.none.fl_str_mv 2007-05-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/120503
Carreras, Maria Cecilia; Poderoso, Juan José; Mitochondrial nitric oxide in the signaling of cell integrated responses; American Physiological Society; American Journal of Physiology-cell Physiology; 292; 5; 1-5-2007; C1569-C1580
0363-6143
CONICET Digital
CONICET
url http://hdl.handle.net/11336/120503
identifier_str_mv Carreras, Maria Cecilia; Poderoso, Juan José; Mitochondrial nitric oxide in the signaling of cell integrated responses; American Physiological Society; American Journal of Physiology-cell Physiology; 292; 5; 1-5-2007; C1569-C1580
0363-6143
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1152/ajpcell.00248.2006
info:eu-repo/semantics/altIdentifier/url/https://journals.physiology.org/doi/full/10.1152/ajpcell.00248.2006
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Physiological Society
publisher.none.fl_str_mv American Physiological Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 15.81155

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