Adrenergic and Endothelin B Receptor-Dependent Hypertension in Dopamine Receptor Type-2 Knockout Mice

Polymorphism of the dopamine receptor type-2 (D2) gene is associated with essential hypertension. To assess whether D2 receptors participate in regulation of blood pressure (BP), we studied mice in which the D2 receptor was disrupted. In anesthetized mice, systolic and diastolic BPs (in millimeters...

Descripción completa

Detalles Bibliográficos
Autores: Li, Xiao Xi, Bek, Martin, Asico, Laureano D., Yang, Zhiwei, Grandy, David K., Goldstein, David S., Rubinstein, Marcelo, Eisner, Gilbert M., Jose, Pedro A.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2001
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/79320
Acceso en línea:http://hdl.handle.net/11336/79320
Access Level:acceso abierto
Palabra clave:Dopamina
Hipertensión
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
id AR_c00e17487d55ab0077afefa7a3045fa3
oai_identifier_str oai:ri.conicet.gov.ar:11336/79320
network_acronym_str AR
network_name_str Argentina
repository_id_str
spelling Adrenergic and Endothelin B Receptor-Dependent Hypertension in Dopamine Receptor Type-2 Knockout MiceLi, Xiao XiBek, MartinAsico, Laureano D.Yang, ZhiweiGrandy, David K.Goldstein, David S.Rubinstein, MarceloEisner, Gilbert M.Jose, Pedro A.DopaminaHipertensiónhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Polymorphism of the dopamine receptor type-2 (D2) gene is associated with essential hypertension. To assess whether D2 receptors participate in regulation of blood pressure (BP), we studied mice in which the D2 receptor was disrupted. In anesthetized mice, systolic and diastolic BPs (in millimeters of mercury) were higher in D2 homozygous and heterozygous mutant mice than in D2+/+ littermates. BP after α-adrenergic blockade decreased to a greater extent in D2−/− mice than in D2+/+ mice. Epinephrine excretion was greater in D2−/− mice than in D2+/+ mice, and acute adrenalectomy decreased BP to a similar level in D2−/− and D2+/+ mice. An endothelin B (ET[B]) receptor blocker for both ET(B1) and ET(B2) receptors decreased, whereas a selective ET(B1) blocker increased, BP in D2−/− mice but not D2+/+ mice. ET(B) receptor expression was greater in D2−/− mice than in D2+/+ mice. In contrast, blockade of ET(A) and V1 vasopressin receptors had no effect on BP in either D2−/− or D2+/+ mice. The hypotensive effect of an AT1 antagonist was also similar in D2−/− and D2+/+ mice. Basal Na+,K+-ATPase activities in renal cortex and medulla were higher in D2+/+ mice than in D2−/− mice. Urine flow and sodium excretion were higher in D2−/− mice than in D2+/+ mice before and after acute saline loading. Thus, complete loss of the D2 receptor results in hypertension that is not due to impairment of sodium excretion. Instead, enhanced vascular reactivity in the D2 mutant mice may be caused by increased sympathetic and ET(B) receptor activities.Fil: Li, Xiao Xi. Georgetown University Medical Center; Estados UnidosFil: Bek, Martin. Georgetown University Medical Center; Estados UnidosFil: Asico, Laureano D.. Georgetown University Medical Center; Estados UnidosFil: Yang, Zhiwei. Georgetown University Medical Center; Estados UnidosFil: Grandy, David K.. Oregon Health Sciences University; Estados UnidosFil: Goldstein, David S.. Oregon Health Sciences University; Estados UnidosFil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Eisner, Gilbert M.. Georgetown University Medical Center; Estados UnidosFil: Jose, Pedro A.. Georgetown University Medical Center; Estados UnidosLippincott Williams2001-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/79320Li, Xiao Xi; Bek, Martin; Asico, Laureano D.; Yang, Zhiwei; Grandy, David K.; et al.; Adrenergic and Endothelin B Receptor-Dependent Hypertension in Dopamine Receptor Type-2 Knockout Mice; Lippincott Williams; Hypertension; 38; 3; 9-2001; 303-3080263-63520194-911XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1161/01.HYP.38.3.303info:eu-repo/semantics/altIdentifier/url/https://www.ahajournals.org/doi/10.1161/01.HYP.38.3.303info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:25:31Zoai:ri.conicet.gov.ar:11336/79320instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:25:31.339CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Adrenergic and Endothelin B Receptor-Dependent Hypertension in Dopamine Receptor Type-2 Knockout Mice
title Adrenergic and Endothelin B Receptor-Dependent Hypertension in Dopamine Receptor Type-2 Knockout Mice
spellingShingle Adrenergic and Endothelin B Receptor-Dependent Hypertension in Dopamine Receptor Type-2 Knockout Mice
Li, Xiao Xi
Dopamina
Hipertensión
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
title_short Adrenergic and Endothelin B Receptor-Dependent Hypertension in Dopamine Receptor Type-2 Knockout Mice
title_full Adrenergic and Endothelin B Receptor-Dependent Hypertension in Dopamine Receptor Type-2 Knockout Mice
title_fullStr Adrenergic and Endothelin B Receptor-Dependent Hypertension in Dopamine Receptor Type-2 Knockout Mice
title_full_unstemmed Adrenergic and Endothelin B Receptor-Dependent Hypertension in Dopamine Receptor Type-2 Knockout Mice
title_sort Adrenergic and Endothelin B Receptor-Dependent Hypertension in Dopamine Receptor Type-2 Knockout Mice
dc.creator.none.fl_str_mv Li, Xiao Xi
Bek, Martin
Asico, Laureano D.
Yang, Zhiwei
Grandy, David K.
Goldstein, David S.
Rubinstein, Marcelo
Eisner, Gilbert M.
Jose, Pedro A.
author Li, Xiao Xi
author_facet Li, Xiao Xi
Bek, Martin
Asico, Laureano D.
Yang, Zhiwei
Grandy, David K.
Goldstein, David S.
Rubinstein, Marcelo
Eisner, Gilbert M.
Jose, Pedro A.
author_role author
author2 Bek, Martin
Asico, Laureano D.
Yang, Zhiwei
Grandy, David K.
Goldstein, David S.
Rubinstein, Marcelo
Eisner, Gilbert M.
Jose, Pedro A.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Dopamina
Hipertensión
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
topic Dopamina
Hipertensión
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
description Polymorphism of the dopamine receptor type-2 (D2) gene is associated with essential hypertension. To assess whether D2 receptors participate in regulation of blood pressure (BP), we studied mice in which the D2 receptor was disrupted. In anesthetized mice, systolic and diastolic BPs (in millimeters of mercury) were higher in D2 homozygous and heterozygous mutant mice than in D2+/+ littermates. BP after α-adrenergic blockade decreased to a greater extent in D2−/− mice than in D2+/+ mice. Epinephrine excretion was greater in D2−/− mice than in D2+/+ mice, and acute adrenalectomy decreased BP to a similar level in D2−/− and D2+/+ mice. An endothelin B (ET[B]) receptor blocker for both ET(B1) and ET(B2) receptors decreased, whereas a selective ET(B1) blocker increased, BP in D2−/− mice but not D2+/+ mice. ET(B) receptor expression was greater in D2−/− mice than in D2+/+ mice. In contrast, blockade of ET(A) and V1 vasopressin receptors had no effect on BP in either D2−/− or D2+/+ mice. The hypotensive effect of an AT1 antagonist was also similar in D2−/− and D2+/+ mice. Basal Na+,K+-ATPase activities in renal cortex and medulla were higher in D2+/+ mice than in D2−/− mice. Urine flow and sodium excretion were higher in D2−/− mice than in D2+/+ mice before and after acute saline loading. Thus, complete loss of the D2 receptor results in hypertension that is not due to impairment of sodium excretion. Instead, enhanced vascular reactivity in the D2 mutant mice may be caused by increased sympathetic and ET(B) receptor activities.
publishDate 2001
dc.date.none.fl_str_mv 2001-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/79320
Li, Xiao Xi; Bek, Martin; Asico, Laureano D.; Yang, Zhiwei; Grandy, David K.; et al.; Adrenergic and Endothelin B Receptor-Dependent Hypertension in Dopamine Receptor Type-2 Knockout Mice; Lippincott Williams; Hypertension; 38; 3; 9-2001; 303-308
0263-6352
0194-911X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/79320
identifier_str_mv Li, Xiao Xi; Bek, Martin; Asico, Laureano D.; Yang, Zhiwei; Grandy, David K.; et al.; Adrenergic and Endothelin B Receptor-Dependent Hypertension in Dopamine Receptor Type-2 Knockout Mice; Lippincott Williams; Hypertension; 38; 3; 9-2001; 303-308
0263-6352
0194-911X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1161/01.HYP.38.3.303
info:eu-repo/semantics/altIdentifier/url/https://www.ahajournals.org/doi/10.1161/01.HYP.38.3.303
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams
publisher.none.fl_str_mv Lippincott Williams
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799196381597925376
score 15,198674

Similares en LA Referencia