Mechanism of the Reaction of Peroxynitrite with Mn-Superoxide Dismutase: Nitration of Critical Tyrosine-34

Manganese superoxide dismutase (MnSOD) is an antioxidantenzyme that acts as a superoxide detoxifier. Superoxide can reactwith nitric oxide to lead peroxynitrite and this reaction, that takesplace at near diffusion limited rates, can compete with MnSOD forsuperoxide. One of the most important bio-mar...

Descripción completa

Detalles Bibliográficos
Autores: Demicheli, Veronica, Moreno, Diego Martin, Jara, Gabriel Ernesto, Carballal, Sebastian, Quijano, Celia, Ferrer Sueta, Gerardo, Rios, Natalia, Estrin, Dario Ariel, Marti, Marcelo Adrian, Radi, Rafael
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/50278
Acceso en línea:http://hdl.handle.net/11336/50278
Access Level:acceso abierto
Palabra clave:Superoxide Dismutase
Nitration
Inactivation
https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
Descripción
Sumario:Manganese superoxide dismutase (MnSOD) is an antioxidantenzyme that acts as a superoxide detoxifier. Superoxide can reactwith nitric oxide to lead peroxynitrite and this reaction, that takesplace at near diffusion limited rates, can compete with MnSOD forsuperoxide. One of the most important bio-markers forperoxynitrite formation in vivo is tyrosine nitration, a posttranslationalmodification that can alter both the structure andfunction of a protein.

Similares en LA Referencia