Iridoids As Allelochemicals and DNA Polymerase Inhibitors ⊥

Growth inhibitory activities and nutritional indices of catalpol (1), 8-O-acetylharpagide (2), and harpagide (3) were determinated in larvae and adults of Tribolium castaneum, respectively. Compound 1 produced a series of allelochemical effects probably related with the DNA synthesis. This iridoid p...

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Bibliographic Details
Authors: Pungitore, Carlos Rodolfo, Juri Ayub, Maximiliano, García, Matías, Borkowski, Eduardo Jorge, Sosa, Marta E., Ciuffo, Gladys Maria, Giordano, Oscar Santiago, Tonn, Carlos Eugenio
Format: article
Status:Published version
Publication Date:2004
Country:Argentina
Institution:Consejo Nacional de Investigaciones Científicas y Técnicas
Repository:CONICET Digital (CONICET)
Language:English
OAI Identifier:oai:ri.conicet.gov.ar:11336/44577
Online Access:http://hdl.handle.net/11336/44577
Access Level:Open access
Keyword:https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
Description
Summary:Growth inhibitory activities and nutritional indices of catalpol (1), 8-O-acetylharpagide (2), and harpagide (3) were determinated in larvae and adults of Tribolium castaneum, respectively. Compound 1 produced a series of allelochemical effects probably related with the DNA synthesis. This iridoid possessed the highest inhibitory activity against DNA polymerase. Molecular orbital calculations suggest that a pi-pi charge transfer recognition model could explain the action of iridioids toward nucleic acid synthesis.

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