Progesterone receptor assembly of a transcriptional complex along with activator protein 1, signal transducer and activator of transcription 3 and ErbB-2 governs breast cancer growth and predicts response to endocrine therapy

The role of the progesterone receptor (PR) in breast cancer remains a major clinical challenge. Although PR induces mammary tumor growth, its presence in breast tumors is a marker of good prognosis. We investigated coordinated PR rapid and nonclassical transcriptional effects governing breast cancer...

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Detalles Bibliográficos
Autores: Díaz Flaqué, María Celeste, Galigniana, Natalia Maricel, Beguelin, Wendy, Vicario, Rocio, Proietti Anastasi, Cecilia Jazmín, Cordo Russo, Rosalia Ines, Rivas, Martin Alfredo, Tkach, Mercedes, Guzmán, Pablo, Roa, Juan C., Maronna, Esteban, Pineda, Viviana, Muñoz, Sergio, Mercogliano, María Florencia, Charreau, Eduardo Hernan, Yankilevich, Patricio, Schillaci, Roxana, Elizalde, Patricia Virginia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/5536
Acceso en línea:http://hdl.handle.net/11336/5536
Access Level:acceso abierto
Palabra clave:PR
BREAST CANCER
ENDOCRINE RESPONSE
TAMOXIFEN RESISTANCE
AP-1
CROSSTALK
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
Descripción
Sumario:The role of the progesterone receptor (PR) in breast cancer remains a major clinical challenge. Although PR induces mammary tumor growth, its presence in breast tumors is a marker of good prognosis. We investigated coordinated PR rapid and nonclassical transcriptional effects governing breast cancer growth and endocrine therapy resistance.

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