The importance of analytical methodology in accurate diagnosis and monitoring of intrahepatic cholestasis of pregnancy

The present case demonstrates the problematic results associated with routine liver tests and enzymatically determined serum total bile acids (TBA).The optimal way to diagnose intrahepatic cholestasis of pregnancy accurately and follow its progression is through evaluation of bile acid profile and s...

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Detalles Bibliográficos
Autores: Martinefski, Manuela Romina, Contin, Mario Daniel, Samassa, Paula, Di Carlo, Maria Beatriz, Lucangioli, Silvia Edith, Tripodi, Valeria Paula
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/1815
Acceso en línea:http://hdl.handle.net/11336/1815
Access Level:acceso abierto
Palabra clave:Bile Acids
Capillary Electrophoresis
Enzymatic Method
Intrahepatic Cholestasis of Pregnancy
Litocholic Acid
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
Descripción
Sumario:The present case demonstrates the problematic results associated with routine liver tests and enzymatically determined serum total bile acids (TBA).The optimal way to diagnose intrahepatic cholestasis of pregnancy accurately and follow its progression is through evaluation of bile acid profile and serum TBA. In the present case, the determination of these parameters via capillary electrophoresis optimized management. Regular monitoring of this disease with adequate analytical methodology is important.