Gastric cytoprotective activity of ilicic aldehyde: structure-activity relationships
A series of sesquiterpene compounds possessing both eudesmane and eremophilane skeletons were tested as gastric cytoprotective agents on male Wistar rats. The presence of an alpha,beta-unsaturated aldehyde on the C-7 side chain together with a hydroxyl group at C-4 is the requirement for the observe...
| Autores: | , , , , , , |
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| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 2005 |
| País: | Argentina |
| Recursos: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositório: | CONICET Digital (CONICET) |
| Idioma: | inglês |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/158921 |
| Acesso em linha: | http://hdl.handle.net/11336/158921 |
| Access Level: | Acceso aberto |
| Palavra-chave: | GASTRIC CYTOPROTECTION SESQUITERPENES ILICIC ALDEHYDE EUDESMANE EREMOPHILANE https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| Resumo: | A series of sesquiterpene compounds possessing both eudesmane and eremophilane skeletons were tested as gastric cytoprotective agents on male Wistar rats. The presence of an alpha,beta-unsaturated aldehyde on the C-7 side chain together with a hydroxyl group at C-4 is the requirement for the observed antiulcerogenic activity. In an attempt to establish new molecular structural requirements for this gastric cytoprotective activity, a structure-activity study was performed. |
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