GHEP-ISFG proficiency test 2011: Paper challenge on evaluation of mitochondrial DNA results

The GHEP-ISFG Working Group performed a collaborative exercise to monitor the current practice of mitochondrial (mt)DNA reporting. The participating laboratories were invited to evaluate a hypothetical case example and assess the statistical significance of a match between the haplotypes of a case (...

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Detalles Bibliográficos
Autores: Prieto, L., Alves, Cíntia, Zimmermann, B., Tagliabracci, A., Prieto, V., Montesino, M., Whitte, M. R., Anjos, M. J., Cardoso, S., Heinrichs, B., Hernandez, A., Lopez Parra, A. M., Sala, Adriana Andrea, Saragoni, V. G., Burgos G., Marino, Miguel Eduardo, Paredes, M., Mora Torres, C. A., Angulo, R., Chemale, G., Vullo, Carlos, Sánchez Simón, M., Comas, D., Puente, J., López Cubría, C. M., Modesti, Nidia Maria, Aler, M., Merigioli, S., Betancor, E., Pedrosa, D., Plaza, G., Masciovecchio, M. V., Schneider, P. M., Parson, Walther
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/26769
Acceso en línea:http://hdl.handle.net/11336/26769
Access Level:acceso abierto
Palabra clave:Mt Dna Interpretation
Ghep-Isfg
Empop
Lr
Database
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
Descripción
Sumario:The GHEP-ISFG Working Group performed a collaborative exercise to monitor the current practice of mitochondrial (mt)DNA reporting. The participating laboratories were invited to evaluate a hypothetical case example and assess the statistical significance of a match between the haplotypes of a case (hair) sample and a suspect. A total of 31 forensic laboratories participated of which all but one used the EMPOP database. Nevertheless, we observed a tenfold range of reported LR values (32–333.4), which was mainly due to the selection of different reference datasets in EMPOP but also due to different applied formulae. The results suggest the need for more standardization as well as additional research to harmonize the reporting of mtDNA evidence.

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