Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern Argentina

Snake species within genus Bothrops are responsible for more than 80% of the snakebites occurring in South America. The species that cause most envenomings in Argentina, B. diporus, is widely distributed throughout the country, but principally found in the Northeast, the region with the highest rate...

Descripción completa

Detalles Bibliográficos
Autores: Gay, Claudia Carolina, Sanz, Libia, Calvete, Juan J., Pla, Davinia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/41152
Acceso en línea:http://hdl.handle.net/11336/41152
Access Level:acceso abierto
Palabra clave:BOTHROPS DIPORUS VENOM
VENOMICS
SNAKE VENOM PROTEOME
ANTIVENOMICS
MASS SPECTROMETRY
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
id AR_b88f00a58e30bc8bac00993f5dfceecf
oai_identifier_str oai:ri.conicet.gov.ar:11336/41152
network_acronym_str AR
network_name_str Argentina
repository_id_str
spelling Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern ArgentinaGay, Claudia CarolinaSanz, LibiaCalvete, Juan J.Pla, DaviniaBOTHROPS DIPORUS VENOMVENOMICSSNAKE VENOM PROTEOMEANTIVENOMICSMASS SPECTROMETRYhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Snake species within genus Bothrops are responsible for more than 80% of the snakebites occurring in South America. The species that cause most envenomings in Argentina, B. diporus, is widely distributed throughout the country, but principally found in the Northeast, the region with the highest rates of snakebites. The venom proteome of this medically relevant snake was unveiled using a venomic approach. It comprises toxins belonging to fourteen protein families,be ing dominated by PI- and PIII-SVMPs, PLA2 molecules, BPP-like peptides, L-amino acid oxidase and serine proteinases. This toxin profile largely explains the characteristic pathophysiological effects of bothropic snakebites observed in patients envenomed by B. diporus. Antivenomic analysis of the SAB antivenom (Instituto Vital Brazil) against the venom of B. diporus showed that this pentabothropic antivenom efficiently recognized all the venom proteins and exhibited poor affinity towards the small peptide (BPPs and tripeptide inhibitors of PIII-SVMPs) components of the venom.Fil: Gay, Claudia Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Química Básica y Aplicada del Nordeste Argentino. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Instituto de Química Básica y Aplicada del Nordeste Argentino; ArgentinaFil: Sanz, Libia. Instituto de Biomedicina de Valencia; EspañaFil: Calvete, Juan J.. Instituto de Biomedicina de Valencia; EspañaFil: Pla, Davinia. Instituto de Biomedicina de Valencia; EspañaMDPI2015-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/41152Gay, Claudia Carolina; Sanz, Libia; Calvete, Juan J.; Pla, Davinia; Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern Argentina; MDPI; Toxins; 8; 1; 12-2015; 1-132072-66512072-6651CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/toxins8010009info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728531/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:35:21Zoai:ri.conicet.gov.ar:11336/41152instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:35:21.388CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern Argentina
title Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern Argentina
spellingShingle Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern Argentina
Gay, Claudia Carolina
BOTHROPS DIPORUS VENOM
VENOMICS
SNAKE VENOM PROTEOME
ANTIVENOMICS
MASS SPECTROMETRY
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
title_short Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern Argentina
title_full Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern Argentina
title_fullStr Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern Argentina
title_full_unstemmed Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern Argentina
title_sort Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern Argentina
dc.creator.none.fl_str_mv Gay, Claudia Carolina
Sanz, Libia
Calvete, Juan J.
Pla, Davinia
author Gay, Claudia Carolina
author_facet Gay, Claudia Carolina
Sanz, Libia
Calvete, Juan J.
Pla, Davinia
author_role author
author2 Sanz, Libia
Calvete, Juan J.
Pla, Davinia
author2_role author
author
author
dc.subject.none.fl_str_mv BOTHROPS DIPORUS VENOM
VENOMICS
SNAKE VENOM PROTEOME
ANTIVENOMICS
MASS SPECTROMETRY
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
topic BOTHROPS DIPORUS VENOM
VENOMICS
SNAKE VENOM PROTEOME
ANTIVENOMICS
MASS SPECTROMETRY
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
description Snake species within genus Bothrops are responsible for more than 80% of the snakebites occurring in South America. The species that cause most envenomings in Argentina, B. diporus, is widely distributed throughout the country, but principally found in the Northeast, the region with the highest rates of snakebites. The venom proteome of this medically relevant snake was unveiled using a venomic approach. It comprises toxins belonging to fourteen protein families,be ing dominated by PI- and PIII-SVMPs, PLA2 molecules, BPP-like peptides, L-amino acid oxidase and serine proteinases. This toxin profile largely explains the characteristic pathophysiological effects of bothropic snakebites observed in patients envenomed by B. diporus. Antivenomic analysis of the SAB antivenom (Instituto Vital Brazil) against the venom of B. diporus showed that this pentabothropic antivenom efficiently recognized all the venom proteins and exhibited poor affinity towards the small peptide (BPPs and tripeptide inhibitors of PIII-SVMPs) components of the venom.
publishDate 2015
dc.date.none.fl_str_mv 2015-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/41152
Gay, Claudia Carolina; Sanz, Libia; Calvete, Juan J.; Pla, Davinia; Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern Argentina; MDPI; Toxins; 8; 1; 12-2015; 1-13
2072-6651
2072-6651
CONICET Digital
CONICET
url http://hdl.handle.net/11336/41152
identifier_str_mv Gay, Claudia Carolina; Sanz, Libia; Calvete, Juan J.; Pla, Davinia; Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern Argentina; MDPI; Toxins; 8; 1; 12-2015; 1-13
2072-6651
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/toxins8010009
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728531/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799194738599919616
score 15,81155

Similares en LA Referencia