CheSweet: An application to predict glycan's chemicals shifts

The knowledge of the tridimensional structure of glycans is necessary to understand in detail, at atomic level, the molecular processes in which they are involved. Chemical Shifts (CS) are observables obtained from Nuclear Magnetic Resonance experiments that are highly sensitive probes to sense conf...

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Detalles Bibliográficos
Autores: Garay, Pablo Germán, Vila, Jorge Alberto, Martín, Osvaldo Antonio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/94554
Acceso en línea:http://hdl.handle.net/11336/94554
Access Level:acceso abierto
Palabra clave:GLYCANS
CHEMICAL SHIFTS
PYTHON
https://purl.org/becyt/ford/1.2
https://purl.org/becyt/ford/1
Descripción
Sumario:The knowledge of the tridimensional structure of glycans is necessary to understand in detail, at atomic level, the molecular processes in which they are involved. Chemical Shifts (CS) are observables obtained from Nuclear Magnetic Resonance experiments that are highly sensitive probes to sense conformational changes. CS can be calculated accurately using quantum chemical tools, although these computations are very demanding for routine computations of more than a few conformations. For that reason we have developed CheSweet, a Python module for accurate and fast computation of CS.