Galectins in intestinal inflammation: Galectin-1 expression delineates response to treatment in celiac disease patients

Galectins, a family of animal lectins characterized by their affinity for N-acetyllactosamine-enriched glycoconjugates, modulate several immune cell processes shaping the course of innate and adaptive immune responses. Through interaction with a wide range of glycosylated receptors bearing complex b...

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Autores: Sundblad, Victoria, Quintar, Amado Alfredo, Morosi, Luciano Gastón, Niveloni, Sonia I., Cabanne, Ana, Smecuol, Edgardo, Mauriño, Eduardo, Mariño, Karina Valeria, Bai, Julio C., Maldonado, Cristina Alicia, Rabinovich, Gabriel Adrián
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/87379
Acceso en línea:http://hdl.handle.net/11336/87379
Access Level:acceso abierto
Palabra clave:CELIAC DISEASE
GALECTIN-1
GALECTINS
GLYCANS
GUT INFLAMMATION
INFLAMMATORY BOWEL DISEASE
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
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oai_identifier_str oai:ri.conicet.gov.ar:11336/87379
network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Galectins in intestinal inflammation: Galectin-1 expression delineates response to treatment in celiac disease patients
title Galectins in intestinal inflammation: Galectin-1 expression delineates response to treatment in celiac disease patients
spellingShingle Galectins in intestinal inflammation: Galectin-1 expression delineates response to treatment in celiac disease patients
Sundblad, Victoria
CELIAC DISEASE
GALECTIN-1
GALECTINS
GLYCANS
GUT INFLAMMATION
INFLAMMATORY BOWEL DISEASE
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
title_short Galectins in intestinal inflammation: Galectin-1 expression delineates response to treatment in celiac disease patients
title_full Galectins in intestinal inflammation: Galectin-1 expression delineates response to treatment in celiac disease patients
title_fullStr Galectins in intestinal inflammation: Galectin-1 expression delineates response to treatment in celiac disease patients
title_full_unstemmed Galectins in intestinal inflammation: Galectin-1 expression delineates response to treatment in celiac disease patients
title_sort Galectins in intestinal inflammation: Galectin-1 expression delineates response to treatment in celiac disease patients
dc.creator.none.fl_str_mv Sundblad, Victoria
Quintar, Amado Alfredo
Morosi, Luciano Gastón
Niveloni, Sonia I.
Cabanne, Ana
Smecuol, Edgardo
Mauriño, Eduardo
Mariño, Karina Valeria
Bai, Julio C.
Maldonado, Cristina Alicia
Rabinovich, Gabriel Adrián
author Sundblad, Victoria
author_facet Sundblad, Victoria
Quintar, Amado Alfredo
Morosi, Luciano Gastón
Niveloni, Sonia I.
Cabanne, Ana
Smecuol, Edgardo
Mauriño, Eduardo
Mariño, Karina Valeria
Bai, Julio C.
Maldonado, Cristina Alicia
Rabinovich, Gabriel Adrián
author_role author
author2 Quintar, Amado Alfredo
Morosi, Luciano Gastón
Niveloni, Sonia I.
Cabanne, Ana
Smecuol, Edgardo
Mauriño, Eduardo
Mariño, Karina Valeria
Bai, Julio C.
Maldonado, Cristina Alicia
Rabinovich, Gabriel Adrián
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CELIAC DISEASE
GALECTIN-1
GALECTINS
GLYCANS
GUT INFLAMMATION
INFLAMMATORY BOWEL DISEASE
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
topic CELIAC DISEASE
GALECTIN-1
GALECTINS
GLYCANS
GUT INFLAMMATION
INFLAMMATORY BOWEL DISEASE
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
description Galectins, a family of animal lectins characterized by their affinity for N-acetyllactosamine-enriched glycoconjugates, modulate several immune cell processes shaping the course of innate and adaptive immune responses. Through interaction with a wide range of glycosylated receptors bearing complex branched N-glycans and core 2-O-glycans, these endogenous lectins trigger distinct signaling programs thereby controling immune cell activation, differentiation, recruitment and survival. Given the unique features of mucosal inflammation and the differential expression of galectins throughout the gastrointestinal tract, we discuss here key findings on the role of galectins in intestinal inflammation, particularly Crohn´s disease, ulcerative colitis, and celiac disease (CeD) patients, as well as in murine models resembling these inflammatory conditions. In addition, we present new data highlighting the regulated expression of galectin-1 (Gal-1), a proto-type member of the galectin family, during intestinal inflammation in untreated and treated CeD patients. Our results unveil a substantial upregulation of Gal-1 accompanying the anti-inflammatory and tolerogenic response associated with gluten-free diet in CeD patients, suggesting a major role of this lectin in favoring resolution of inflammation and restoration of mucosal homeostasis. Thus, a coordinated network of galectins and their glycosylated ligands, exerting either anti-inflammatory or proinflammatory responses, may influence the interplay between intestinal epithelial cells and the highly specialized gut immune system in physiologic and pathologic settings.
publishDate 2018
dc.date.none.fl_str_mv 2018-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/87379
Sundblad, Victoria; Quintar, Amado Alfredo; Morosi, Luciano Gastón; Niveloni, Sonia I.; Cabanne, Ana; et al.; Galectins in intestinal inflammation: Galectin-1 expression delineates response to treatment in celiac disease patients; Frontiers Media S.A.; Frontiers in Immunology; 9; MAR; 3-2018
1664-3224
CONICET Digital
CONICET
url http://hdl.handle.net/11336/87379
identifier_str_mv Sundblad, Victoria; Quintar, Amado Alfredo; Morosi, Luciano Gastón; Niveloni, Sonia I.; Cabanne, Ana; et al.; Galectins in intestinal inflammation: Galectin-1 expression delineates response to treatment in celiac disease patients; Frontiers Media S.A.; Frontiers in Immunology; 9; MAR; 3-2018
1664-3224
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://journal.frontiersin.org/article/10.3389/fimmu.2018.00379/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2018.00379
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799195266067202048
spelling Galectins in intestinal inflammation: Galectin-1 expression delineates response to treatment in celiac disease patientsSundblad, VictoriaQuintar, Amado AlfredoMorosi, Luciano GastónNiveloni, Sonia I.Cabanne, AnaSmecuol, EdgardoMauriño, EduardoMariño, Karina ValeriaBai, Julio C.Maldonado, Cristina AliciaRabinovich, Gabriel AdriánCELIAC DISEASEGALECTIN-1GALECTINSGLYCANSGUT INFLAMMATIONINFLAMMATORY BOWEL DISEASEhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Galectins, a family of animal lectins characterized by their affinity for N-acetyllactosamine-enriched glycoconjugates, modulate several immune cell processes shaping the course of innate and adaptive immune responses. Through interaction with a wide range of glycosylated receptors bearing complex branched N-glycans and core 2-O-glycans, these endogenous lectins trigger distinct signaling programs thereby controling immune cell activation, differentiation, recruitment and survival. Given the unique features of mucosal inflammation and the differential expression of galectins throughout the gastrointestinal tract, we discuss here key findings on the role of galectins in intestinal inflammation, particularly Crohn´s disease, ulcerative colitis, and celiac disease (CeD) patients, as well as in murine models resembling these inflammatory conditions. In addition, we present new data highlighting the regulated expression of galectin-1 (Gal-1), a proto-type member of the galectin family, during intestinal inflammation in untreated and treated CeD patients. Our results unveil a substantial upregulation of Gal-1 accompanying the anti-inflammatory and tolerogenic response associated with gluten-free diet in CeD patients, suggesting a major role of this lectin in favoring resolution of inflammation and restoration of mucosal homeostasis. Thus, a coordinated network of galectins and their glycosylated ligands, exerting either anti-inflammatory or proinflammatory responses, may influence the interplay between intestinal epithelial cells and the highly specialized gut immune system in physiologic and pathologic settings.Fil: Sundblad, Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Quintar, Amado Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba; ArgentinaFil: Morosi, Luciano Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Niveloni, Sonia I.. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; ArgentinaFil: Cabanne, Ana. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; ArgentinaFil: Smecuol, Edgardo. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; ArgentinaFil: Mauriño, Eduardo. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; ArgentinaFil: Mariño, Karina Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Bai, Julio C.. Universidad del Salvador; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; ArgentinaFil: Maldonado, Cristina Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba; ArgentinaFil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFrontiers Media S.A.2018-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/87379Sundblad, Victoria; Quintar, Amado Alfredo; Morosi, Luciano Gastón; Niveloni, Sonia I.; Cabanne, Ana; et al.; Galectins in intestinal inflammation: Galectin-1 expression delineates response to treatment in celiac disease patients; Frontiers Media S.A.; Frontiers in Immunology; 9; MAR; 3-20181664-3224CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://journal.frontiersin.org/article/10.3389/fimmu.2018.00379/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2018.00379info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:47:32Zoai:ri.conicet.gov.ar:11336/87379instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:47:33.016CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
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