Diagnostic value of salivary cortisol in end stage renal disease

Objectives: Salivary cortisol has been proposed a surrogate marker for free serum cortisol measurements. The aim of this study was to ascertain the diagnostic value of basal and stimulated salivary cortisol for the detection of adrenal insufficiency (AI) in hypotensive end stage renal disease (ESRD)...

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Autores: Arregger, Alejandro Luis, Cardoso, Estela M. del Luján, Tumilasci, Omar Rene, Contreras, Liliana Noemí
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2008
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/104670
Acceso en línea:http://hdl.handle.net/11336/104670
Access Level:acceso abierto
Palabra clave:salivary cortisol
renal disease
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
id AR_b5cd795eb65ca9b5f3bfd382fcbcd26f
oai_identifier_str oai:ri.conicet.gov.ar:11336/104670
network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Diagnostic value of salivary cortisol in end stage renal disease
title Diagnostic value of salivary cortisol in end stage renal disease
spellingShingle Diagnostic value of salivary cortisol in end stage renal disease
Arregger, Alejandro Luis
salivary cortisol
renal disease
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
title_short Diagnostic value of salivary cortisol in end stage renal disease
title_full Diagnostic value of salivary cortisol in end stage renal disease
title_fullStr Diagnostic value of salivary cortisol in end stage renal disease
title_full_unstemmed Diagnostic value of salivary cortisol in end stage renal disease
title_sort Diagnostic value of salivary cortisol in end stage renal disease
dc.creator.none.fl_str_mv Arregger, Alejandro Luis
Cardoso, Estela M. del Luján
Tumilasci, Omar Rene
Contreras, Liliana Noemí
author Arregger, Alejandro Luis
author_facet Arregger, Alejandro Luis
Cardoso, Estela M. del Luján
Tumilasci, Omar Rene
Contreras, Liliana Noemí
author_role author
author2 Cardoso, Estela M. del Luján
Tumilasci, Omar Rene
Contreras, Liliana Noemí
author2_role author
author
author
dc.subject.none.fl_str_mv salivary cortisol
renal disease
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
topic salivary cortisol
renal disease
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
description Objectives: Salivary cortisol has been proposed a surrogate marker for free serum cortisol measurements. The aim of this study was to ascertain the diagnostic value of basal and stimulated salivary cortisol for the detection of adrenal insufficiency (AI) in hypotensive end stage renal disease (ESRD) patients. Basal salivary cortisol and basal total serum cortisol were studied in order to determine the accuracy of both biomarkers in predicting AI. Patients and methods: Twenty-nine ESRD patients with sustained hypotension were investigated for possible AI. Salivary cortisol was assessed at baseline and 30 min after 25 μg ACTH i.m. (LDTs). The dosage of salivary aldosterone was performed in salivary cortisol hypo-responders. Basal blood samples were drawn for steroids, renin and ACTH measurements. Results: A clear separation between patients with normal and impaired adrenal function was obtained through salivary cortisol levels at 30 min after ACTH. AI was detected in six cases (21%) through impaired salivary cortisol responses; stimulated salivary aldosterone helped to differentiate primary (n = 3) from secondary AI (n = 3). ROC curves showed that cutoff values for basal SAF ≤4.4 nM and serum cortisol ≤232.0 nM suggest AI (sensitivities: 93% and 69%; specificities: 86.4% and 91%, respectively). Conclusions: We conclude that ACTH stimulated SAF is an accurate biomarker for the diagnosis of AI in hypotensive ESRD patients. Neither basal salivary cortisol nor serum cortisol showed 100% sensitivities for the detection of AI.
publishDate 2008
dc.date.none.fl_str_mv 2008-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/104670
Arregger, Alejandro Luis; Cardoso, Estela M. del Luján; Tumilasci, Omar Rene; Contreras, Liliana Noemí; Diagnostic value of salivary cortisol in end stage renal disease; Elsevier Science Inc; Steroids; 73; 1; 1-2008; 77-82
0039-128X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/104670
identifier_str_mv Arregger, Alejandro Luis; Cardoso, Estela M. del Luján; Tumilasci, Omar Rene; Contreras, Liliana Noemí; Diagnostic value of salivary cortisol in end stage renal disease; Elsevier Science Inc; Steroids; 73; 1; 1-2008; 77-82
0039-128X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0039128X07001602
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.steroids.2007.09.001
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc
publisher.none.fl_str_mv Elsevier Science Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799194981892620288
spelling Diagnostic value of salivary cortisol in end stage renal diseaseArregger, Alejandro LuisCardoso, Estela M. del LujánTumilasci, Omar ReneContreras, Liliana Noemísalivary cortisolrenal diseasehttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Objectives: Salivary cortisol has been proposed a surrogate marker for free serum cortisol measurements. The aim of this study was to ascertain the diagnostic value of basal and stimulated salivary cortisol for the detection of adrenal insufficiency (AI) in hypotensive end stage renal disease (ESRD) patients. Basal salivary cortisol and basal total serum cortisol were studied in order to determine the accuracy of both biomarkers in predicting AI. Patients and methods: Twenty-nine ESRD patients with sustained hypotension were investigated for possible AI. Salivary cortisol was assessed at baseline and 30 min after 25 μg ACTH i.m. (LDTs). The dosage of salivary aldosterone was performed in salivary cortisol hypo-responders. Basal blood samples were drawn for steroids, renin and ACTH measurements. Results: A clear separation between patients with normal and impaired adrenal function was obtained through salivary cortisol levels at 30 min after ACTH. AI was detected in six cases (21%) through impaired salivary cortisol responses; stimulated salivary aldosterone helped to differentiate primary (n = 3) from secondary AI (n = 3). ROC curves showed that cutoff values for basal SAF ≤4.4 nM and serum cortisol ≤232.0 nM suggest AI (sensitivities: 93% and 69%; specificities: 86.4% and 91%, respectively). Conclusions: We conclude that ACTH stimulated SAF is an accurate biomarker for the diagnosis of AI in hypotensive ESRD patients. Neither basal salivary cortisol nor serum cortisol showed 100% sensitivities for the detection of AI.Fil: Arregger, Alejandro Luis. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cardoso, Estela M. del Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Tumilasci, Omar Rene. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Contreras, Liliana Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaElsevier Science Inc2008-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/104670Arregger, Alejandro Luis; Cardoso, Estela M. del Luján; Tumilasci, Omar Rene; Contreras, Liliana Noemí; Diagnostic value of salivary cortisol in end stage renal disease; Elsevier Science Inc; Steroids; 73; 1; 1-2008; 77-820039-128XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0039128X07001602info:eu-repo/semantics/altIdentifier/doi/10.1016/j.steroids.2007.09.001info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:40:29Zoai:ri.conicet.gov.ar:11336/104670instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:40:29.645CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
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