Galectins: new agonists of platelet activation
Platelet activation at sites of vascular injury leads to the formation of a hemostatic plug and is crucial for hemostasis. However, uncontrolled platelet activation may lead to the formation of occlusive thrombi. Several soluble or matricellular proteins can activate platelets. In this article, we r...
| Autores: | , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2013 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/20861 |
| Acceso en línea: | http://hdl.handle.net/11336/20861 |
| Access Level: | acceso abierto |
| Palabra clave: | GALECTINS PLATELETS HEMOSTASIS ATHEROSCLEROSIS CANCER INFLAMMATION https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| Sumario: | Platelet activation at sites of vascular injury leads to the formation of a hemostatic plug and is crucial for hemostasis. However, uncontrolled platelet activation may lead to the formation of occlusive thrombi. Several soluble or matricellular proteins can activate platelets. In this article, we review recent advances in knowledge of the role of galectins in platelet physiology. In soluble or immobilized form, these endogenous glycan-binding proteins trigger platelet activation through the modulation of discrete signaling pathways. We discuss the role of platelet–galectin interactions not only in hemostasis, but also in chronic inflammation, atherosclerosis and cancer. |
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