Humoral response and neutralising capacity at 6 months post-vaccination against COVID-19 among institutionalised older adults in Argentina

The COVID-19 pandemic has particularly affected older adults residing in nursing homes, resulting in high rates of hospitalisation and death. Here, we evaluated the longitudinal humoral response and neutralising capacity in plasma samples of volunteers vaccinated with different platforms (Sputnik V,...

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Bibliographic Details
Authors: Rodriguez, Pamela Elizabeth, Silva, Andrea Paula, Miglietta, Esteban Alberto, Rall, Pablo, Pascuale, Carla Antonela, Ballejo, Christian Adrian, López Miranda, Lucía, Rios, Antonella Soledad, Ramis, Lila Yanina, Marro, Jimena, Poncet, Verónica, Mazzitelli, Bianca, Salvatori, Melina, Ceballos, Ana, González López Ledesma, María Mora, Ojeda, Diego Sebastian, Aguirre, María F., Miragaya, Yanina, Gamarnik, Andrea Vanesa, Rossi, Andrés Hugo
Format: article
Status:Published version
Publication Date:2022
Country:Argentina
Institution:Consejo Nacional de Investigaciones Científicas y Técnicas
Repository:CONICET Digital (CONICET)
Language:English
OAI Identifier:oai:ri.conicet.gov.ar:11336/212931
Online Access:http://hdl.handle.net/11336/212931
Access Level:Open access
Keyword:AGING ADULTS
ANTI-SPIKE IGG
AZD1222
BBIBP-CORV
NEUTRALISING ANTIBODIES
OMICRON
SARS-COV-2
SPUTNIK-V
COVID-19
https://purl.org/becyt/ford/1.1
https://purl.org/becyt/ford/1
Description
Summary:The COVID-19 pandemic has particularly affected older adults residing in nursing homes, resulting in high rates of hospitalisation and death. Here, we evaluated the longitudinal humoral response and neutralising capacity in plasma samples of volunteers vaccinated with different platforms (Sputnik V, BBIBP-CorV, and AZD1222). A cohort of 851 participants, mean age 83 (60-103 years), from the province of Buenos Aires, Argentina were included. Sequential plasma samples were taken at different time points after vaccination. After completing the vaccination schedule, infection-naïve volunteers who received either Sputnik V or AZD1222 exhibited significantly higher specific anti-Spike IgG titers than those who received BBIBP-CorV. Strong correlation between anti-Spike IgG titers and neutralising activity levels was evidenced at all times studied (rho=0.7 a 0.9). Previous exposure to SARS-CoV-2 and age <80 years were both associated with higher specific antibody levels. No differences in neutralising capacity were observed for the infection-naïve participants in either gender or age group. Similar to anti-Spike IgG titers, neutralising capacity decreased 3 to 9-fold at 6 months after initial vaccination for all platforms. Neutralising capacity against Omicron was between 10-58 fold lower compared to ancestral B.1 for all vaccine platforms at 21 days post dose 2 and 180 days post dose 1. This work provides evidence about the humoral response and neutralising capacity elicited by vaccination of a vulnerable elderly population. This data could be useful for pandemic management in defining public health policies, highlighting the need to apply reinforcements after a complete vaccination schedule.

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