B-type and C-type natriuretic peptides modify norepinephrine uptake in discrete encephalic nuclei of the rat

1. We previously demonstrated that atrial natriuretic factor and B- and C-type natriuretic peptides (ANF, BNP, and CNP, respectively) modified catecholamine metabolism by increasing the neuronal uptake and decreasing the neuronal release of norepinephrine in the rat hypothalamus. The aim of the pres...

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Detalles Bibliográficos
Autores: Rodríguez Fermepin, Martin, Vatta, Marcelo Sergio, Bianciotti, Liliana Graciela, Wolovich, Tamara J., Fernandez, Belisario Enrique
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2000
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/163371
Acceso en línea:http://hdl.handle.net/11336/163371
Access Level:acceso abierto
Palabra clave:ANF
BNP
CNP
DIENCEPHALIC, TELENCEPHALIC, AND MIELENCEPHALIC AREAS
LC
NATRIURETIC PEPTIDES
NOREPINEPHRINE UPTAKE
NTS
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
id AR_b3bca798e8d46e8c366d78e247ee282e
oai_identifier_str oai:ri.conicet.gov.ar:11336/163371
network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv B-type and C-type natriuretic peptides modify norepinephrine uptake in discrete encephalic nuclei of the rat
title B-type and C-type natriuretic peptides modify norepinephrine uptake in discrete encephalic nuclei of the rat
spellingShingle B-type and C-type natriuretic peptides modify norepinephrine uptake in discrete encephalic nuclei of the rat
Rodríguez Fermepin, Martin
ANF
BNP
CNP
DIENCEPHALIC, TELENCEPHALIC, AND MIELENCEPHALIC AREAS
LC
NATRIURETIC PEPTIDES
NOREPINEPHRINE UPTAKE
NTS
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
title_short B-type and C-type natriuretic peptides modify norepinephrine uptake in discrete encephalic nuclei of the rat
title_full B-type and C-type natriuretic peptides modify norepinephrine uptake in discrete encephalic nuclei of the rat
title_fullStr B-type and C-type natriuretic peptides modify norepinephrine uptake in discrete encephalic nuclei of the rat
title_full_unstemmed B-type and C-type natriuretic peptides modify norepinephrine uptake in discrete encephalic nuclei of the rat
title_sort B-type and C-type natriuretic peptides modify norepinephrine uptake in discrete encephalic nuclei of the rat
dc.creator.none.fl_str_mv Rodríguez Fermepin, Martin
Vatta, Marcelo Sergio
Bianciotti, Liliana Graciela
Wolovich, Tamara J.
Fernandez, Belisario Enrique
author Rodríguez Fermepin, Martin
author_facet Rodríguez Fermepin, Martin
Vatta, Marcelo Sergio
Bianciotti, Liliana Graciela
Wolovich, Tamara J.
Fernandez, Belisario Enrique
author_role author
author2 Vatta, Marcelo Sergio
Bianciotti, Liliana Graciela
Wolovich, Tamara J.
Fernandez, Belisario Enrique
author2_role author
author
author
author
dc.subject.none.fl_str_mv ANF
BNP
CNP
DIENCEPHALIC, TELENCEPHALIC, AND MIELENCEPHALIC AREAS
LC
NATRIURETIC PEPTIDES
NOREPINEPHRINE UPTAKE
NTS
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
topic ANF
BNP
CNP
DIENCEPHALIC, TELENCEPHALIC, AND MIELENCEPHALIC AREAS
LC
NATRIURETIC PEPTIDES
NOREPINEPHRINE UPTAKE
NTS
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
description 1. We previously demonstrated that atrial natriuretic factor and B- and C-type natriuretic peptides (ANF, BNP, and CNP, respectively) modified catecholamine metabolism by increasing the neuronal uptake and decreasing the neuronal release of norepinephrine in the rat hypothalamus. The aim of the present work was to study the effects of natriuretie peptides BNP and CNP on norepinephrine uptake as an index of the amine metabolism in discrete areas and nuclei of the central nervous system (CNS) of the rat. 2. Experiments were carried out in vitro using the punchout technique in diverse areas and nuclei of rat CNS. Results showed that 100 nM BNP and 1 nM CNP incresed norepinephrine (NE) uptake in all brain areas and nuclei studied. 3. Present results permit us to conclude that BNP and CNP regulate NE metabolism independently of the encephalic area or nucleus involved, In fact, NE uptake increased in nuclei related to the regullation of cardivascular activity as well as nuclei associated with endocrine metabolism and hydrosaline homeostasis. These observations suggest that BNP and CNP may be involved in the regulation of these physiological processes in an indirect manner through modifications of noradrenergic neurotransmission. Present findings provide luther support to the hypothesis that CNP would be the main natriuretic peptide in brain. Furthermore, previous as well as present results support the role of the natriureic peptides as neuromodulators of noradrenergic transmission at the presynaptic level.
publishDate 2000
dc.date.none.fl_str_mv 2000-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/163371
Rodríguez Fermepin, Martin; Vatta, Marcelo Sergio; Bianciotti, Liliana Graciela; Wolovich, Tamara J.; Fernandez, Belisario Enrique; B-type and C-type natriuretic peptides modify norepinephrine uptake in discrete encephalic nuclei of the rat; Springer/Plenum Publishers; Cellular and Molecular Neurobiology; 20; 6; 12-2000; 763-771
0272-4340
CONICET Digital
CONICET
url http://hdl.handle.net/11336/163371
identifier_str_mv Rodríguez Fermepin, Martin; Vatta, Marcelo Sergio; Bianciotti, Liliana Graciela; Wolovich, Tamara J.; Fernandez, Belisario Enrique; B-type and C-type natriuretic peptides modify norepinephrine uptake in discrete encephalic nuclei of the rat; Springer/Plenum Publishers; Cellular and Molecular Neurobiology; 20; 6; 12-2000; 763-771
0272-4340
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1023/A:1007011127409
info:eu-repo/semantics/altIdentifier/doi/10.1023/A:1007011127409
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer/Plenum Publishers
publisher.none.fl_str_mv Springer/Plenum Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799195776283312128
spelling B-type and C-type natriuretic peptides modify norepinephrine uptake in discrete encephalic nuclei of the ratRodríguez Fermepin, MartinVatta, Marcelo SergioBianciotti, Liliana GracielaWolovich, Tamara J.Fernandez, Belisario EnriqueANFBNPCNPDIENCEPHALIC, TELENCEPHALIC, AND MIELENCEPHALIC AREASLCNATRIURETIC PEPTIDESNOREPINEPHRINE UPTAKENTShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/31. We previously demonstrated that atrial natriuretic factor and B- and C-type natriuretic peptides (ANF, BNP, and CNP, respectively) modified catecholamine metabolism by increasing the neuronal uptake and decreasing the neuronal release of norepinephrine in the rat hypothalamus. The aim of the present work was to study the effects of natriuretie peptides BNP and CNP on norepinephrine uptake as an index of the amine metabolism in discrete areas and nuclei of the central nervous system (CNS) of the rat. 2. Experiments were carried out in vitro using the punchout technique in diverse areas and nuclei of rat CNS. Results showed that 100 nM BNP and 1 nM CNP incresed norepinephrine (NE) uptake in all brain areas and nuclei studied. 3. Present results permit us to conclude that BNP and CNP regulate NE metabolism independently of the encephalic area or nucleus involved, In fact, NE uptake increased in nuclei related to the regullation of cardivascular activity as well as nuclei associated with endocrine metabolism and hydrosaline homeostasis. These observations suggest that BNP and CNP may be involved in the regulation of these physiological processes in an indirect manner through modifications of noradrenergic neurotransmission. Present findings provide luther support to the hypothesis that CNP would be the main natriuretic peptide in brain. Furthermore, previous as well as present results support the role of the natriureic peptides as neuromodulators of noradrenergic transmission at the presynaptic level.Fil: Rodríguez Fermepin, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiopatología; ArgentinaFil: Vatta, Marcelo Sergio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiología Humana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Bianciotti, Liliana Graciela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiopatología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Wolovich, Tamara J.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiopatología; ArgentinaFil: Fernandez, Belisario Enrique. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiopatología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaSpringer/Plenum Publishers2000-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/163371Rodríguez Fermepin, Martin; Vatta, Marcelo Sergio; Bianciotti, Liliana Graciela; Wolovich, Tamara J.; Fernandez, Belisario Enrique; B-type and C-type natriuretic peptides modify norepinephrine uptake in discrete encephalic nuclei of the rat; Springer/Plenum Publishers; Cellular and Molecular Neurobiology; 20; 6; 12-2000; 763-7710272-4340CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1023/A:1007011127409info:eu-repo/semantics/altIdentifier/doi/10.1023/A:1007011127409info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T14:03:08Zoai:ri.conicet.gov.ar:11336/163371instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 14:03:08.781CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
score 15,812455

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