Inhibitory effects of ghrelin on sexual behavior: Role of the peptide in the receptivity reduction induced by food restriction in mice
Ghrelin (Ghr) is a gut/hypothalamus peptide with inhibitory actions on reproductive physiology; however, there are no previous reports of its role on estrous behavior. Under the hypothesis that the increase of plasma Ghr during food restriction (FR) is responsible for receptivity reduction, we inten...
| Autores: | , , , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2011 |
| País: | Argentina |
| Recursos: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/230825 |
| Acesso em linha: | http://hdl.handle.net/11336/230825 |
| Access Level: | acceso abierto |
| Palavra-chave: | GRHELIN ANTAGONIST (D-LYS3)-GHRP6 SEXUAL BEHAVIOR https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
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| dc.title.none.fl_str_mv |
Inhibitory effects of ghrelin on sexual behavior: Role of the peptide in the receptivity reduction induced by food restriction in mice |
| title |
Inhibitory effects of ghrelin on sexual behavior: Role of the peptide in the receptivity reduction induced by food restriction in mice |
| spellingShingle |
Inhibitory effects of ghrelin on sexual behavior: Role of the peptide in the receptivity reduction induced by food restriction in mice Bertoldi, María Laura GRHELIN ANTAGONIST (D-LYS3)-GHRP6 SEXUAL BEHAVIOR https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| title_short |
Inhibitory effects of ghrelin on sexual behavior: Role of the peptide in the receptivity reduction induced by food restriction in mice |
| title_full |
Inhibitory effects of ghrelin on sexual behavior: Role of the peptide in the receptivity reduction induced by food restriction in mice |
| title_fullStr |
Inhibitory effects of ghrelin on sexual behavior: Role of the peptide in the receptivity reduction induced by food restriction in mice |
| title_full_unstemmed |
Inhibitory effects of ghrelin on sexual behavior: Role of the peptide in the receptivity reduction induced by food restriction in mice |
| title_sort |
Inhibitory effects of ghrelin on sexual behavior: Role of the peptide in the receptivity reduction induced by food restriction in mice |
| dc.creator.none.fl_str_mv |
Bertoldi, María Laura Luque, E. M. Carlini, Valeria Paola Vincenti, Laura María Stutz, Graciela Santillán, M.E. Ruiz, R. D. Fiol de Cuneo, Marta Martini, Ana Carolina |
| author |
Bertoldi, María Laura |
| author_facet |
Bertoldi, María Laura Luque, E. M. Carlini, Valeria Paola Vincenti, Laura María Stutz, Graciela Santillán, M.E. Ruiz, R. D. Fiol de Cuneo, Marta Martini, Ana Carolina |
| author_role |
author |
| author2 |
Luque, E. M. Carlini, Valeria Paola Vincenti, Laura María Stutz, Graciela Santillán, M.E. Ruiz, R. D. Fiol de Cuneo, Marta Martini, Ana Carolina |
| author2_role |
author author author author author author author author |
| dc.subject.none.fl_str_mv |
GRHELIN ANTAGONIST (D-LYS3)-GHRP6 SEXUAL BEHAVIOR https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| topic |
GRHELIN ANTAGONIST (D-LYS3)-GHRP6 SEXUAL BEHAVIOR https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| description |
Ghrelin (Ghr) is a gut/hypothalamus peptide with inhibitory actions on reproductive physiology; however, there are no previous reports of its role on estrous behavior. Under the hypothesis that the increase of plasma Ghr during food restriction (FR) is responsible for receptivity reduction, we intended to evaluate the receptivity percentage of female mice subjected to: exp. 1) acute and chronic FR and Ghr administration (3 nmol/animal/day, s. c.) and exp. 2) the co-administration of a ghrelin antagonist [ant=(d-Lys3)-GHRP-6; 6 nmol/animal/day s. c.]. All females were ovariectomized, primed with steroids, trained, and randomly subjected every week to each one of several protocols, followed by a behavioral test. Experiment 1 (n=8): basal, no treatment; acute FR (aFR), 24-h fasting; chronic FR (cFR), 50% FR for 5 days; acute ghrelin (aGhr), Ghr 30 min before test and chronic ghrelin (cGhr), Ghr for 5 days. Except for cGhr, all treatments significantly decreased the percentage of receptivity (mean±SEM): basal 61.9±6.0, aFR 33.1±8.1, cFR 18.8±7.7, aGhr 45.6±10.6, p<0.05 vs. basal. In exp. 2 (n=11), except for cFR+ant (55.0±6.4) the co-administration of the antagonist reversed the deleterious effects detected in exp. 1: basal 70.9±5.4; aFR+ant 72.3±7.6; aGhr+ant 73.6±4.7. As expected, the administration of vehicle or antagonist alone did not modify receptivity. Besides, we found a significant correlation between percentage of body weight loss and percentage of receptivity reduction (r=0.62, p=0.0004). This is the first study demonstrating that ghrelin is able to inhibit female mice sexual behavior and that is involved, at least in part, in receptivity reduction after food scarcity. |
| publishDate |
2011 |
| dc.date.none.fl_str_mv |
2011-04 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/230825 Bertoldi, María Laura; Luque, E. M.; Carlini, Valeria Paola; Vincenti, Laura María; Stutz, Graciela; et al.; Inhibitory effects of ghrelin on sexual behavior: Role of the peptide in the receptivity reduction induced by food restriction in mice; Georg Thieme Verlagiaorl@iaorl.org; Hormone and Metabolic Research; 43; 7; 4-2011; 494-499 0018-5043 1439-4286 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/230825 |
| identifier_str_mv |
Bertoldi, María Laura; Luque, E. M.; Carlini, Valeria Paola; Vincenti, Laura María; Stutz, Graciela; et al.; Inhibitory effects of ghrelin on sexual behavior: Role of the peptide in the receptivity reduction induced by food restriction in mice; Georg Thieme Verlagiaorl@iaorl.org; Hormone and Metabolic Research; 43; 7; 4-2011; 494-499 0018-5043 1439-4286 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.thieme-connect.com/DOI/DOI?10.1055/s-0031-1277228 info:eu-repo/semantics/altIdentifier/doi/10.1055/s-0031-1277228 |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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openAccess |
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https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
| dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Georg Thieme Verlagiaorl@iaorl.org |
| publisher.none.fl_str_mv |
Georg Thieme Verlagiaorl@iaorl.org |
| dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
| reponame_str |
CONICET Digital (CONICET) |
| collection |
CONICET Digital (CONICET) |
| repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
| _version_ |
1799195097313574912 |
| spelling |
Inhibitory effects of ghrelin on sexual behavior: Role of the peptide in the receptivity reduction induced by food restriction in miceBertoldi, María LauraLuque, E. M.Carlini, Valeria PaolaVincenti, Laura MaríaStutz, GracielaSantillán, M.E.Ruiz, R. D.Fiol de Cuneo, MartaMartini, Ana CarolinaGRHELIN ANTAGONIST(D-LYS3)-GHRP6SEXUAL BEHAVIORhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Ghrelin (Ghr) is a gut/hypothalamus peptide with inhibitory actions on reproductive physiology; however, there are no previous reports of its role on estrous behavior. Under the hypothesis that the increase of plasma Ghr during food restriction (FR) is responsible for receptivity reduction, we intended to evaluate the receptivity percentage of female mice subjected to: exp. 1) acute and chronic FR and Ghr administration (3 nmol/animal/day, s. c.) and exp. 2) the co-administration of a ghrelin antagonist [ant=(d-Lys3)-GHRP-6; 6 nmol/animal/day s. c.]. All females were ovariectomized, primed with steroids, trained, and randomly subjected every week to each one of several protocols, followed by a behavioral test. Experiment 1 (n=8): basal, no treatment; acute FR (aFR), 24-h fasting; chronic FR (cFR), 50% FR for 5 days; acute ghrelin (aGhr), Ghr 30 min before test and chronic ghrelin (cGhr), Ghr for 5 days. Except for cGhr, all treatments significantly decreased the percentage of receptivity (mean±SEM): basal 61.9±6.0, aFR 33.1±8.1, cFR 18.8±7.7, aGhr 45.6±10.6, p<0.05 vs. basal. In exp. 2 (n=11), except for cFR+ant (55.0±6.4) the co-administration of the antagonist reversed the deleterious effects detected in exp. 1: basal 70.9±5.4; aFR+ant 72.3±7.6; aGhr+ant 73.6±4.7. As expected, the administration of vehicle or antagonist alone did not modify receptivity. Besides, we found a significant correlation between percentage of body weight loss and percentage of receptivity reduction (r=0.62, p=0.0004). This is the first study demonstrating that ghrelin is able to inhibit female mice sexual behavior and that is involved, at least in part, in receptivity reduction after food scarcity.Fil: Bertoldi, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; ArgentinaFil: Luque, E. M.. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;Fil: Carlini, Valeria Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Vincenti, Laura María. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;Fil: Stutz, Graciela. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;Fil: Santillán, M.E.. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;Fil: Ruiz, R. D.. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;Fil: Fiol de Cuneo, Marta. Universidad Nacional de Cordoba. Facultad de Ciencias Medicas. Instituto de Fisiologia Profesor Oscar Orias;Fil: Martini, Ana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaGeorg Thieme Verlagiaorl@iaorl.org2011-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/230825Bertoldi, María Laura; Luque, E. M.; Carlini, Valeria Paola; Vincenti, Laura María; Stutz, Graciela; et al.; Inhibitory effects of ghrelin on sexual behavior: Role of the peptide in the receptivity reduction induced by food restriction in mice; Georg Thieme Verlagiaorl@iaorl.org; Hormone and Metabolic Research; 43; 7; 4-2011; 494-4990018-50431439-4286CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.thieme-connect.com/DOI/DOI?10.1055/s-0031-1277228info:eu-repo/semantics/altIdentifier/doi/10.1055/s-0031-1277228info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:43:26Zoai:ri.conicet.gov.ar:11336/230825instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:43:26.557CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
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15.812429 |