Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: Combined administration of BSH and BPA

Sodium mercaptoundecahydro-closo-dodecaborate (BSH) is being investigated clinically for BNCT. We examined the biodistribution of BSH and BPA administered jointly in different proportions in the hamster cheek pouch oral cancer model. The 3 assayed protocols were non-toxic, and showed preferential tu...

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Detalles Bibliográficos
Autores: Garabalino, Marcela Alejandra, Heber, Elisa Mercedes, Monti Hughes, Andrea, Pozzi, Emiliano César Cayetano, Molinari, Ana Julia, Nigg, David W., Bauer, William, Trivillin, Verónica Andrea, Schwint, Amanda Elena
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/24103
Acceso en línea:http://hdl.handle.net/11336/24103
Access Level:acceso abierto
Palabra clave:Boron Neutron Capture Therapy
Bnct
Oral Cancer
Bpa
Bsh
Hamster Cheek Pouch Oral Cancer Model
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
Descripción
Sumario:Sodium mercaptoundecahydro-closo-dodecaborate (BSH) is being investigated clinically for BNCT. We examined the biodistribution of BSH and BPA administered jointly in different proportions in the hamster cheek pouch oral cancer model. The 3 assayed protocols were non-toxic, and showed preferential tumor boron uptake versus precancerous and normal tissue and therapeutic tumor boron concentration values (70-85ppm). All 3 protocols warrant assessment in BNCT studies to contribute to the knowledge of (BSH+BPA)-BNCT radiobiology for head and neck cancer and optimize therapeutic efficacy.

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