Effect of hydromechanical stress on cellular antigens of Bordetella pertussis

Cells of Bordetella pertussis grown in a bioreactor under stirring conditions were studied to investigate the effect of shear stress on cellular-bound filamentous haemagglutinin (FHA). FHA attached to the bacterial surface, unlike extracellular FHA, was not affected at the shear levels tested. Moreo...

Descripción completa

Detalles Bibliográficos
Autores: Rodríguez, María Eugenia, Hozbor, Daniela Flavia, Yantorno, Osvaldo Miguel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:1996
País:Argentina
Institución:Universidad Nacional de La Plata
Repositorio:SEDICI (UNLP)
Idioma:inglés
OAI Identifier:oai:sedici.unlp.edu.ar:10915/137827
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/137827
Access Level:acceso abierto
Palabra clave:Ciencias Exactas
Bordetella pertussis
cellular antigens
pertussis vaccine
shear stress
Descripción
Sumario:Cells of Bordetella pertussis grown in a bioreactor under stirring conditions were studied to investigate the effect of shear stress on cellular-bound filamentous haemagglutinin (FHA). FHA attached to the bacterial surface, unlike extracellular FHA, was not affected at the shear levels tested. Moreover, no other cellular immunogen involved in the whole-cell protective activity seemed to be affected by hydromechanical forces.