Bromocryptine restores angiotensin II response in pituitary hyperplasia

In estrogen-induced pituitary hyperplasia AII-evoked prolactin release is decreased and the octapeptide does not generate a spike elevation in [Ca(2+)](i) in vitro. We studied whether or not bromocriptine could restore AII response in diethylstilbestrol treated rats. Co-administration of bromocripti...

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Detalles Bibliográficos
Autores: González Iglesias, A., Diaz, Graciela Susana, Piroli, Gerardo Gustavo, Achával Zaia, R., de Nicola, Alejandro Federico, Libertun, Carlos, Becu, Damasia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2000
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/30716
Acceso en línea:http://hdl.handle.net/11336/30716
Access Level:acceso abierto
Palabra clave:Endocrinology
Angiotensin
Calcium
Hyperplasia
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
id AR_afdf9783d253db8c57de07b65fd30aa2
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network_acronym_str AR
network_name_str Argentina
repository_id_str
dc.title.none.fl_str_mv Bromocryptine restores angiotensin II response in pituitary hyperplasia
title Bromocryptine restores angiotensin II response in pituitary hyperplasia
spellingShingle Bromocryptine restores angiotensin II response in pituitary hyperplasia
González Iglesias, A.
Endocrinology
Angiotensin
Calcium
Hyperplasia
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
title_short Bromocryptine restores angiotensin II response in pituitary hyperplasia
title_full Bromocryptine restores angiotensin II response in pituitary hyperplasia
title_fullStr Bromocryptine restores angiotensin II response in pituitary hyperplasia
title_full_unstemmed Bromocryptine restores angiotensin II response in pituitary hyperplasia
title_sort Bromocryptine restores angiotensin II response in pituitary hyperplasia
dc.creator.none.fl_str_mv González Iglesias, A.
Diaz, Graciela Susana
Piroli, Gerardo Gustavo
Achával Zaia, R.
de Nicola, Alejandro Federico
Libertun, Carlos
Becu, Damasia
author González Iglesias, A.
author_facet González Iglesias, A.
Diaz, Graciela Susana
Piroli, Gerardo Gustavo
Achával Zaia, R.
de Nicola, Alejandro Federico
Libertun, Carlos
Becu, Damasia
author_role author
author2 Diaz, Graciela Susana
Piroli, Gerardo Gustavo
Achával Zaia, R.
de Nicola, Alejandro Federico
Libertun, Carlos
Becu, Damasia
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Endocrinology
Angiotensin
Calcium
Hyperplasia
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
topic Endocrinology
Angiotensin
Calcium
Hyperplasia
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
description In estrogen-induced pituitary hyperplasia AII-evoked prolactin release is decreased and the octapeptide does not generate a spike elevation in [Ca(2+)](i) in vitro. We studied whether or not bromocriptine could restore AII response in diethylstilbestrol treated rats. Co-administration of bromocriptine resulted in involution of pituitary size and lowering of serum prolactin. In vitro, prolactin release per cell was reduced in the hyperplastic group, and levels were not significantly increased by in vivo bromocriptine treatment. Immunocytochemical analysis revealed that hyperplastic pituitaries contained fewer prolactin granules than control pituitaries, and that bromocriptine, did not increase prolactin storage. Nevertheless, in this group, prolactin response to AII increased, and AII evoked a consistent spike in [Ca(2+)](i), albeit lower than in the control group. Such spike was abolished by thapsigargin, and not by removal of extracellular calcium or by K(+), indicating that it was mainly dependent on intracellular calcium stores, as in normal cells. We conclude that bromocriptine treatment partially restores AII response in the hyperplastic pituitary.
publishDate 2000
dc.date.none.fl_str_mv 2000
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/30716
González Iglesias, A.; Diaz, Graciela Susana; Piroli, Gerardo Gustavo; Achával Zaia, R.; de Nicola, Alejandro Federico; et al.; Bromocryptine restores angiotensin II response in pituitary hyperplasia; Elsevier Ireland; Molecular and Cellular Endocrinology; 165; 1-2; 2000; 67-74
0303-7207
CONICET Digital
CONICET
url http://hdl.handle.net/11336/30716
identifier_str_mv González Iglesias, A.; Diaz, Graciela Susana; Piroli, Gerardo Gustavo; Achával Zaia, R.; de Nicola, Alejandro Federico; et al.; Bromocryptine restores angiotensin II response in pituitary hyperplasia; Elsevier Ireland; Molecular and Cellular Endocrinology; 165; 1-2; 2000; 67-74
0303-7207
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0303720700002707?via%3Dihub
info:eu-repo/semantics/altIdentifier/doi/10.1016/S0303-7207(00)00270-7
info:eu-repo/semantics/altIdentifier/pmid/10940485
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799194626673868800
spelling Bromocryptine restores angiotensin II response in pituitary hyperplasiaGonzález Iglesias, A.Diaz, Graciela SusanaPiroli, Gerardo GustavoAchával Zaia, R.de Nicola, Alejandro FedericoLibertun, CarlosBecu, DamasiaEndocrinologyAngiotensinCalciumHyperplasiahttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3In estrogen-induced pituitary hyperplasia AII-evoked prolactin release is decreased and the octapeptide does not generate a spike elevation in [Ca(2+)](i) in vitro. We studied whether or not bromocriptine could restore AII response in diethylstilbestrol treated rats. Co-administration of bromocriptine resulted in involution of pituitary size and lowering of serum prolactin. In vitro, prolactin release per cell was reduced in the hyperplastic group, and levels were not significantly increased by in vivo bromocriptine treatment. Immunocytochemical analysis revealed that hyperplastic pituitaries contained fewer prolactin granules than control pituitaries, and that bromocriptine, did not increase prolactin storage. Nevertheless, in this group, prolactin response to AII increased, and AII evoked a consistent spike in [Ca(2+)](i), albeit lower than in the control group. Such spike was abolished by thapsigargin, and not by removal of extracellular calcium or by K(+), indicating that it was mainly dependent on intracellular calcium stores, as in normal cells. We conclude that bromocriptine treatment partially restores AII response in the hyperplastic pituitary.Fil: González Iglesias, A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Diaz, Graciela Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Piroli, G.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Achával Zaia, R.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: de Nicola, Alejandro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Libertun, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Becu, Damasia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaElsevier Ireland2000info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/30716González Iglesias, A.; Diaz, Graciela Susana; Piroli, Gerardo Gustavo; Achával Zaia, R.; de Nicola, Alejandro Federico; et al.; Bromocryptine restores angiotensin II response in pituitary hyperplasia; Elsevier Ireland; Molecular and Cellular Endocrinology; 165; 1-2; 2000; 67-740303-7207CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0303720700002707?via%3Dihubinfo:eu-repo/semantics/altIdentifier/doi/10.1016/S0303-7207(00)00270-7info:eu-repo/semantics/altIdentifier/pmid/10940485info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:33:03Zoai:ri.conicet.gov.ar:11336/30716instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:33:03.308CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
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