Ursodeoxycholic and deoxycholic acids: A good and a bad bile acid for intestinal calcium absorption
The aim of this study was to investigate the effect of ursodeoxycholic acid (UDCA) on intestinal Ca2+ absorption and to find out whether the inhibition of this process caused by NaDOC could be prevented by UDCA. Chicks were employed and divided into four groups: (a) controls, (b) treated with 10 mM...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2013 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/11407 |
| Acceso en línea: | http://hdl.handle.net/11336/11407 |
| Access Level: | acceso abierto |
| Palabra clave: | Udca Nadoc Intestinal Ca2+ Absorption Ca2+-Atpase Na+/Ca2+ Exchange Calbindin D28k https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| Sumario: | The aim of this study was to investigate the effect of ursodeoxycholic acid (UDCA) on intestinal Ca2+ absorption and to find out whether the inhibition of this process caused by NaDOC could be prevented by UDCA. Chicks were employed and divided into four groups: (a) controls, (b) treated with 10 mM NaDOC, (c) treated with 60 lg UDCA/100 g of b.w., and (d) treated with 10 mM NaDOC and 60 lg UDCA/100 g of b.w. UDCA enhanced intestinal Ca2+ absorption, which was time and dose-dependent. UDCA avoided the inhibition of intestinal Ca2+ absorption caused by NaDOC. Both bile acids altered protein and gene expression of molecules involved in the transcellular pathway of intestinal Ca2+ absorption, but in the opposite way. UDCA aborted the oxidative stress produced by NaDOC in the intestine. UDCA and UDCA plus NaDOC increased vitamin D receptor protein expression. In conclusion, UDCA is a bene- ficial bile acid for intestinal Ca2+ absorption. Contrarily, NaDOC inhibits the intestinal cation absorption through triggering oxidative stress. The use of UDCA in patients with cholestasis would be benefited because of the protective effect on the intestinal Ca2+ absorption, avoiding the inhibition caused by hydrophobic bile acids and neutralizing the oxidative stress. |
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