A biological classification for Alzheimer's disease - Amyloid, Tau and Neurodegeneration (A/T/N): Results from the Argentine-Alzheimer's Disease Neuroimaging Initiative

Objective: To describe the Amyloid, Tau, Neurodegeneration (A/T/N) research framework classification in the Argentine-Alzheimer Neuroimaging Initiative (ADNI) cohort. Methods: 23 Mild Cognitive Impairment (MCI), 12 Alzheimer?s Disease (AD) and 14 controls were studied with the ADNI-2 protocol. Patie...

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Detalles Bibliográficos
Autores: Allegri, Ricardo Francisco, Pertierra, Lucia, Cohen, Gabriela, Chrem Mendez, Patricio Alexis, Russo, María Julieta, Calandri, Ismael, Bagnati, Pablo, Tapajoz Pereira de Sampaio, Fernanda, Clarens, Florencia, Campos, Jorge, Nahas, Federico Exequiel, Surace, Ezequiel Ignacio, Vázquez, Silvia, Sevlever, Gustavo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/86126
Acceso en línea:http://hdl.handle.net/11336/86126
Access Level:acceso abierto
Palabra clave:Alzheimer
Biomarkers
ATN
MCI
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
Descripción
Sumario:Objective: To describe the Amyloid, Tau, Neurodegeneration (A/T/N) research framework classification in the Argentine-Alzheimer Neuroimaging Initiative (ADNI) cohort. Methods: 23 Mild Cognitive Impairment (MCI), 12 Alzheimer?s Disease (AD) and 14 controls were studied with the ADNI-2 protocol. Patients were categorized according to ?A? Aβ biomarkers, ?T? tau biomarker, and ?N? neurodegeneration. Results: A+/T+/N+ at baseline was found in 2/14 controls (14%), 2/10 early MCI (20%), 6/13 late MCI (46%) and 11/12 mild dementia (91%). Suspected non- AD pathophysiology (SNAP, A-/T-/N+) was found in 1/14 controls (7%), 2/10 early MCI (20%), 2/13 late MCI (15%) and 1/12 mild dementia (8%). MCI with A+/T+/N+ showed 75% (6/8) and A-/T-/N+ 50% (2/4) of conversion to dementia in two years.Conclusions: This is the first report from this region based on AD biomarkers and the new A/T/N classification. Our findings suggest that this biological classification is better for prognosis in a short time than the classical clinical one.

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