Artificial Pancreas: First Clinical Trials in Argentina

The first clinical trials using an Artificial Pancreas (AP) in Latin America have been defined in 2 stages. The first stage was carried out in November 2016 with the UVA controller (developed by the Center for Diabetes Technology and already clinically tested), and the second will be performed durin...

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Detalles Bibliográficos
Autores: Sánchez Peña, R., Colmegna, Patricio Hernán, Grosembacher, L., Breton, M., De Battista, Hernán, Garelli, Fabricio, Belloso, W. H., Campos Náñez, E., Simonovich, V., Beruto, V., Scibona, P., Cherñavvsky, D.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:Argentina
Institución:Universidad Nacional de La Plata
Repositorio:SEDICI (UNLP)
Idioma:inglés
OAI Identifier:oai:sedici.unlp.edu.ar:10915/146889
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/146889
Access Level:acceso abierto
Palabra clave:Ingeniería Electrónica
Ciencias Médicas
Artificial Pancreas
type 1 diabetes mellitus
switched control
LQG control
sliding mode control
clinical trial
Descripción
Sumario:The first clinical trials using an Artificial Pancreas (AP) in Latin America have been defined in 2 stages. The first stage was carried out in November 2016 with the UVA controller (developed by the Center for Diabetes Technology and already clinically tested), and the second will be performed during the first semester of 2017 with the ARG (Automatic Regulation of Glucose) algorithm (developed by ITBA, UNQ, and UNLP in Argentina). Both tests are based on the DiAs (Diabetes Assistant) from the UVA, and are performed in the HIBA on 5 patients with Type 1 Diabetes Mellitus (T1DM), for 36 hours. For the first stage, Open-Loop (OL) insulin boluses were applied before meals and patient’s physical activity was included. On the other hand, for the second stage, patients will not be involved in physical activity, but no OL insulin boluses will be injected before meals. In this work, experimental results from the first stage with the UVA controller, and preliminary results with the ARG control algorithm tested on the UVA/Padova simulator are presented. Due to the final paper deadline, the experimental results from the second stage are not included here, but will be presented at the IFAC World Congress.